Extra‑articular synovial osteochondroma of the Hoffa's fat pad involving the patellar tendon: A case report and literature review
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- Published online on: February 18, 2020 https://doi.org/10.3892/mco.2020.1998
- Pages: 355-357
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Copyright: © Hashimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Abstract
Introduction
Synovial osteochondroma (SO) is a relatively uncommon disorder characterized by the development of hyaline cartilage tissue from the synovium (1). It typically presents as knee arthropathy, and is thought to arise from a metaplastic process on the synovial membrane (2). This cartilaginous tissue may form loose bodies in the joint and become symptomatic (3). Malignant transformation to chondrosarcoma is uncommon but has been described (4). SO usually involves the joints, such as the knee, hip, ankle, elbow, wrist, and shoulder joints (5). Extra-articular lesions are relatively uncommon and mainly observed in a synovial sheath or the bursa of the foot or hand (6). Large extra-articular lesions of the Hoffa's fat pad are rare. The present study presents a case of extra-articular SO of the right knee in a 56-year-old woman. This is the first case of large extra-articular SO involving the patellar tendon with restriction of range of motion in the knee.
Case report
A 56-year-old woman presented at Kindai University Hospital (Osaka, Japan) with a 2-year history of knee pain associated with an enlarging mass on the anterior of the right knee. She had only a past medical history of a benign breast tumor.
Examination of the right knee joint revealed an 8x9-cm elastic hard mass lesion on the anterolateral right knee. The patient had restricted range of motion (0-130 degrees) of the knee, and deep flexion aggravated the pain. Her inflammatory markers were normal. Radiography showed enhancement of soft part shadows and calcification at the Hoffa's fat pad (data not shown). Bone scintigraphy showed abnormal accumulation in the front of the right knee in the early phase that decreased in the delay phase (Fig. 1A). Computed tomography showed an iso- to low-intensity mass involving the patellar tendon at the Hoffa's fat pad lesion with calcification (Fig. 1B and C). T1-weighted magnetic resonance imaging (MRI) showed an iso-intensity mass (Fig. 1D and E), and T2-weighted MRI showed a high-intensity mass (Fig. 1F and G). We conducted needle biopsy. The histology showed synovial tissue and chondrocyte tissue fragments (data not shown). No malignancy was detected. The patient underwent marginal resection. Adhesion to the tissue surrounding the tumor mass was confirmed. The tumor mass also adhered to the patellar tendon, and we released the adhesion of the tumor mass and patellar tendon. It was easy to release the tendon from the tumor.
After the surgery, the patellar tendon was not damaged (Fig. 2A). The excised specimen showed an elastic, hard, white-yellow covering (Fig. 2B). Hematoxylin and eosin staining showed hyaline cartilage and trabecular bone formation (Fig. 2C and D). Osteoblasts lined the trabecular bone, and scattered osteoclasts were observed (Fig. 2C and D). Spindle-like cell proliferation was observed between the trabeculae (Fig. 2C and D). We diagnosed SO by the histological findings. Radiography after surgery confirmed that there was no damage to the patellar tendon (Fig. 2E). The range of motion had improved (0-145 degrees), and the knee pain during deep flexion disappeared.
Discussion
Extra-articular SO often occurs at the site of the Hoffa's fat pad (7). However, extra-articular SO involving the patellar tendon has not been previously reported. To the best of our knowledge, this is the first case of extra-articular SO involving the patellar tendon.
The etiology of para-articular osteochondroma has not been clarified (8). Metaplasia from extra-synovial mesenchymal cells can be the origin of osteochondroma (8). Repeated trauma can also cause metaplasia (9,10). Moreover, SO of the Hoffa's fat pad is considered the final stage of inflammation after injury (11). The possibility of existence of occult injury history of the Hoffa's fat pad was also considered in the present case. The differential diagnosis of SO in this location includes para-articular osteochondroma, Hoffa's disease, and primary chondrosarcoma (12). Extra-articular synovial osteochondroma should be differentiated from para-articular osteochondroma of the infrapatellar fat pad (13). On histologic examination, hypercellular hyaline cartilage arising from the synovium is detected, and nuclear atypia is common. Benign synovial chondromatosis can be difficult to differentiate histologically from low-grade chondrosarcoma; some features more suggestive of malignancy include cartilaginous cells in sheets rather than clusters, myxoid changes, and the presence of necrosis (1-3). However, no definitive criteria for the diagnosis of malignancy exist. In the present case, no clear malignant findings were detected.
We observed calcification by radiography, which is common in such cases (14-16). Computed tomography or MRI more commonly lead to characterization of the lesion and can be diagnostic. Non-calcified and calcified lesions may be differentiated on MRI because non-mineralized chondromata are isointense on T1-but hyperintense on T2-weighted images (17), as observed in the present study.
With regard to the treatment of SO, marginal resection is preferable when possible (4,5). Over-wide surgical treatment should be avoided (18). Our patient underwent marginal resection and has a good prognosis without functional disorder. If restriction of knee range of motion is observed, as in the present case, resection should be performed as early as possible. Long-term follow-up is crucial because of the high rate of recurrence and risk of malignant transformation (19).
Similar tumors have been reported in recent years (15,16). Both cases originated from the Hoffa's fat pad and caused knee pain. One patient demonstrated an impingement of the knee joint (15). However, unlike our case, the tumors in both cases did not show involvement of the patellar tendon. Based on these findings, the present case was more advanced than those limited to the Hoffa's fat pad. Therefore, the present case is unique in that it demonstrates that advanced cases with patellar tendon involvement may be cured by marginal resection.
Acknowledgements
We thank Editage for the English editing.
Funding
Not applicable.
Availability of data and materials
All data generated or analyzed during this study are included in this published article.
Authors' contributions
SN, SI, KN, SA, IT, KY, RK, KH and MA analyzed and interpreted the patient data. All authors read and approved the final manuscript.
Ethics approval and consent to participate
The procedures followed were in accordance with the Ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2013. The patients also provided written informed consent for this retrospective study.
Patient consent for publication
We obtained written informed consent for publication from the patient.
Competing interests
The authors declare that they have no competing interests.
References
Trevino M, Laks S, Kafchinski L, Sundarakumar DK and Smith CM: Intermetatarsal bursa primary synovial chondromatosis: Case report and review of the literature. Skeletal Radiol. 46:1769–1773. 2017.PubMed/NCBI View Article : Google Scholar | |
Temponi EF, Mortati RB, Mortati GMH, Mortati LB, Sonnery-Cottet B and de Carvalho Júnior LH: Synovial chondromatosis of the knee in a 2-year-old Child: A case report and review of the literature. JBJS Case Connect. 6(e71)2016.PubMed/NCBI View Article : Google Scholar | |
Raval P, Vijayan A and Jariwala A: Arthroscopic retrieval of over 100 loose bodies in shoulder synovial chondromatosis: A case report and review of literature. Orthop Surg. 8:511–515. 2016.PubMed/NCBI View Article : Google Scholar | |
Ng VY, Louie P, Punt S and Conrad EU: Malignant transformation of synovial chondromatosis: A systematic review. Open Orthop J. 11:517–524. 2017.PubMed/NCBI View Article : Google Scholar | |
Lohmann CH, Köster G, Klinger HM and Kunze E: Giant synovial osteochondromatosis of the acromio-clavicular joint in a child. A case report and review of the literature. J Pediatr Orthop B. 14:126–128. 2005.PubMed/NCBI View Article : Google Scholar | |
Doral MN, Uzumcugil A, Bozkurt M, Atay OA, Cil A, Leblebicioglu G and Tetik O: Arthroscopic treatment of synovial chondromatosis of the ankle. J Foot Ankle Surg. 46:192–195. 2007.PubMed/NCBI View Article : Google Scholar | |
O'Connell L, Memon AR, Foran P, Leen E and Kenny PJ: Synovial chondroma in Hoffa's fat pad: Case report and literature review of a rare disorder. Int J Surg Case Rep. 32:80–82. 2017.PubMed/NCBI View Article : Google Scholar | |
Li C, Arger PH and Dalinka MK: Soft tissue osteochondroma. A report of three cases. Skeletal Radiol. 18:435–437. 1989.PubMed/NCBI View Article : Google Scholar | |
Kautz FG: Capsular osteoma of the knee joint. Report of four cases. Radiology. 45:162–167. 1945. View Article : Google Scholar | |
Krebs VE and Parker RD: Arthroscopic resection of an extrasynovial ossifying chondroma of the infrapatellar fat pad: End-stage Hoffa's disease? Arthroscopy. 10:301–304. 1994.PubMed/NCBI View Article : Google Scholar | |
Turhan E, Doral MN, Atay AO and Demirel M: A giant extrasynovial osteochondroma in the infrapatellar fat pad: End stage Hoffa's disease. Arch Orthop Trauma Surg. 128:515–519. 2008.PubMed/NCBI View Article : Google Scholar | |
Ogura K, Goto T, Nemoto T and Imanishi J: Para-articular osteochondroma of the infrapatellar fat pad. J Knee Surg. 24:209–213. 2011.PubMed/NCBI View Article : Google Scholar | |
Sakai H, Tamai K, Iwamoto A and Saotome K: Para-articular chondroma and osteochondroma of the infrapatellar fat pad: A report of three cases. Int Orthop. 23:114–117. 1999.PubMed/NCBI View Article : Google Scholar | |
Osti L, Papalia R, Del Buono A, Denaro V and Maffulli N: Recurrence of synovial chondromatosis of the Hoffa's body. Knee Surg Sports Traumatol Arthrosc. 17:1421–1424. 2009.PubMed/NCBI View Article : Google Scholar | |
Maljanovič M, Ristič V, Rasovič P, Matijevič R and Milankov V: Solitary synovial chondromatosis as a cause of Hoffa's fat pad impingement. Med Pregl. 68:49–52. 2015.PubMed/NCBI View Article : Google Scholar | |
Lee DH and Jeong TW: Uncommon primary synovial chondromatosis involving only the infrapatellar fat pad in an elderly patient. Knee Surg Relat Res. 28:79–82. 2016.PubMed/NCBI View Article : Google Scholar | |
Sheldon PJ, Forreste DM and Learch TJ: Imaging of intraarticular masses. Radiographics. 25:105–119. 2005.PubMed/NCBI View Article : Google Scholar | |
Maheshwari AV, Muro-Cacho CA and Pitcher JD Jr: Extraskeletal para-articular osteochondroma of the posterior knee. J Knee Surg. 22:30–33. 2009.PubMed/NCBI View Article : Google Scholar | |
Bashaireh KM: Patellar subluxation with early-phase synovial chondromatosis of the knee. Orthopedics. 39:e176–e179. 2016.PubMed/NCBI View Article : Google Scholar |