Radiotherapy for symptom palliation of splenomegaly in patients with haematological malignancies

  • Authors:
    • Atsuto Katano
    • Aki Ishida
    • Hideomi Yamashita
    • Keiichi Nakagawa
  • View Affiliations

  • Published online on: April 7, 2021     https://doi.org/10.3892/mco.2021.2276
  • Article Number: 114
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Abstract

Splenomegaly severely compromises the quality of life of those affected. The aim of the present study was to describe the clinical characteristics of patients with haematological disorders who receive radiotherapy for splenomegaly, particularly focusing on the changes in spleen volume. The present study conducted a retrospective analysis of consecutive patients with haematological disorders who underwent splenic radiotherapy with palliative intent at the Department of Radiology of the University of Tokyo Hospital between June 2008 and June 2019. Pre‑ and post‑radiotherapy spleen volumes were measured from computed tomography images. A total of 8 patients (5 men and 3 women) with a median age of 59 years (range, 46‑76 years) were included. The median total prescription and fractional doses were 4.5 Gy (range, 1.5‑10 Gy) and 0.78 Gy (range, 0.5‑2.0 Gy), respectively. A total of 5 patients (62.5%) experienced a reduction in spleen volume. The mean ± SD spleen sizes pre‑ and post‑radiotherapy were 1,887±1,011 and 1,368±577 ml, respectively. The mean variation rate in spleen volume was ‑19.1±24.7%, and the case with the most notable improvement in the present study exhibited a ‑52.4% change. Of the 5 patients who experienced pain prior to radiotherapy, 3 achieved pain relief, 1 did not experience any change and 1 patient was not assessed post‑radiotherapy. Therefore, the findings of the present study revealed that palliative radiotherapy for splenomegaly may achieve symptom palliation and radiological volumetric effects in patients with haematological disorders.

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June-2021
Volume 14 Issue 6

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Spandidos Publications style
Katano A, Ishida A, Yamashita H and Nakagawa K: Radiotherapy for symptom palliation of splenomegaly in patients with haematological malignancies. Mol Clin Oncol 14: 114, 2021
APA
Katano, A., Ishida, A., Yamashita, H., & Nakagawa, K. (2021). Radiotherapy for symptom palliation of splenomegaly in patients with haematological malignancies. Molecular and Clinical Oncology, 14, 114. https://doi.org/10.3892/mco.2021.2276
MLA
Katano, A., Ishida, A., Yamashita, H., Nakagawa, K."Radiotherapy for symptom palliation of splenomegaly in patients with haematological malignancies". Molecular and Clinical Oncology 14.6 (2021): 114.
Chicago
Katano, A., Ishida, A., Yamashita, H., Nakagawa, K."Radiotherapy for symptom palliation of splenomegaly in patients with haematological malignancies". Molecular and Clinical Oncology 14, no. 6 (2021): 114. https://doi.org/10.3892/mco.2021.2276