Bevacizumab based chemotherapy is a promising option in metastatic gallbladder adenocarcinoma

  • Authors:
    • Suhas V. Aagre
    • Mubarakunnisa Tonse
    • Avinash Talele
    • Sanjay Sharma
    • Suresh H. Advani
  • View Affiliations

  • Published online on: June 7, 2021     https://doi.org/10.3892/mco.2021.2315
  • Article Number: 153
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Abstract

Gallbladder cancer (GBC) is one of the most frequently observed cancers in India that is usually diagnosed at an advanced stage. Although surgery remains the only curative option, the majority of GBCs are unresectable. Palliative chemotherapy with gemcitabine and cisplatin is the recommended treatment in such cases. The current study reports a case of a 47‑year‑old female who exhibited GBC that had metastasized to the liver and peritoneum. She was administered palliative chemotherapy with gemcitabine and cisplatin, but due to disease progression the regimen was changed and an aggressive treatment initiated with gemcitabine and oxaliplatin with additional biosimilar bevacizumab (modified Gemox‑B regimen). The patient completed six chemotherapy cycles with partial response and received bevacizumab (7.5 mg/kg 3‑weekly) based maintenance treatment for an additional 6 cycles, after which she demonstrated disease progression, thus having a progression free survival of ~11 months. The patient is currently receiving palliative chemotherapy with capecitabine.

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August-2021
Volume 15 Issue 2

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Spandidos Publications style
Aagre SV, Tonse M, Talele A, Sharma S and Advani SH: Bevacizumab based chemotherapy is a promising option in metastatic gallbladder adenocarcinoma. Mol Clin Oncol 15: 153, 2021
APA
Aagre, S.V., Tonse, M., Talele, A., Sharma, S., & Advani, S.H. (2021). Bevacizumab based chemotherapy is a promising option in metastatic gallbladder adenocarcinoma. Molecular and Clinical Oncology, 15, 153. https://doi.org/10.3892/mco.2021.2315
MLA
Aagre, S. V., Tonse, M., Talele, A., Sharma, S., Advani, S. H."Bevacizumab based chemotherapy is a promising option in metastatic gallbladder adenocarcinoma". Molecular and Clinical Oncology 15.2 (2021): 153.
Chicago
Aagre, S. V., Tonse, M., Talele, A., Sharma, S., Advani, S. H."Bevacizumab based chemotherapy is a promising option in metastatic gallbladder adenocarcinoma". Molecular and Clinical Oncology 15, no. 2 (2021): 153. https://doi.org/10.3892/mco.2021.2315