Open Access

Real‑world effect of bevacizumab and eribulin on metastatic breast cancer using a propensity score matching analysis

  • Authors:
    • Koshi Matsui
    • Mitsuharu Earashi
    • Akemi Yoshikawa
    • Wataru Fukushima
    • Zensei Nozaki
    • Kaeko Oyama
    • Kiichi Maeda
    • Akiyoshi Nakakura
    • Satoshi Morita
    • Tsutomu Fujii
  • View Affiliations

  • Published online on: January 13, 2023     https://doi.org/10.3892/mco.2023.2608
  • Article Number: 12
  • Copyright: © Matsui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bevacizumab and eribulin are novel agents for the treatment of HER2‑negative metastatic breast cancer (MBC); however, the choice between bevacizumab and eribulin for MBC can be difficult. The present study aimed to compare two treatment strategies, eribulin followed by bevacizumab and paclitaxel (BEV + PTX) versus BEV + PTX followed by eribulin, to determine whether the order of administration affects the outcome of MBC in the real world. A total of 180 patients who started BEV + PTX and eribulin treatment for HER2‑negative MBC from August 2011 to June 2018 were selected. Of these, 84 patients were treated with both BEV + PTX and eribulin sequentially. To evaluate the influence of the sequential order, the efficacy of BEV + PTX followed by eribulin (B‑E arm) was compared to treatment with the reverse sequence (E‑B arm). The propensity score matching method (PSMA) was used to improve the robustness of the findings from the present study. A total of 60 cases analyzed received BEV + PTX or eribulin as either first‑ or second‑line treatment. In the entire cohort, the median time to failure of strategy (TFS) was 16.8 and 9.9 months in the B‑E and E‑B arms, respectively [hazard ratio (HR)=0.515, 95% CI 0.298‑0.889, P=0.017). A similar HR was derived from PSMA for TFS. Using PSMA, TFS was 16.9 and 9.9 months in the B‑E and E‑B arms, respectively (HR=0.491, 95% CI 0.253‑0.952, P=0.031). These results suggested that when both bevacizumab and eribulin are administered, bevacizumab should be administered first and eribulin should be administered later to ensure the most effective use of each drug.

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February-2023
Volume 18 Issue 2

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Spandidos Publications style
Matsui K, Earashi M, Yoshikawa A, Fukushima W, Nozaki Z, Oyama K, Maeda K, Nakakura A, Morita S, Fujii T, Fujii T, et al: Real‑world effect of bevacizumab and eribulin on metastatic breast cancer using a propensity score matching analysis. Mol Clin Oncol 18: 12, 2023
APA
Matsui, K., Earashi, M., Yoshikawa, A., Fukushima, W., Nozaki, Z., Oyama, K. ... Fujii, T. (2023). Real‑world effect of bevacizumab and eribulin on metastatic breast cancer using a propensity score matching analysis. Molecular and Clinical Oncology, 18, 12. https://doi.org/10.3892/mco.2023.2608
MLA
Matsui, K., Earashi, M., Yoshikawa, A., Fukushima, W., Nozaki, Z., Oyama, K., Maeda, K., Nakakura, A., Morita, S., Fujii, T."Real‑world effect of bevacizumab and eribulin on metastatic breast cancer using a propensity score matching analysis". Molecular and Clinical Oncology 18.2 (2023): 12.
Chicago
Matsui, K., Earashi, M., Yoshikawa, A., Fukushima, W., Nozaki, Z., Oyama, K., Maeda, K., Nakakura, A., Morita, S., Fujii, T."Real‑world effect of bevacizumab and eribulin on metastatic breast cancer using a propensity score matching analysis". Molecular and Clinical Oncology 18, no. 2 (2023): 12. https://doi.org/10.3892/mco.2023.2608