Open Access

Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review

  • Authors:
    • Saywan K. Asaad
    • Ari M. Abdullah
    • Shkar Ali Abdalrahman
    • Fattah H. Fattah
    • Soran H. Tahir
    • Choman Sabah Omer
    • Rezheen J. Rashid
    • Marwan N. Hassan
    • Shvan H. Mohammed
    • Fahmi H. Kakamad
    • Berun A. Abdalla
  • View Affiliations

  • Published online on: September 7, 2023     https://doi.org/10.3892/mco.2023.2680
  • Article Number: 84
  • Copyright: © Asaad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aggressive fibromatosis is a rare clonal proliferative tumor arising from mesenchymal cells in the fascia and musculoaponeurotic structures. The aim of the present study was to describe several cases of extra‑abdominal recurrent aggressive fibromatosis. The present study was a single‑center retrospective case series of patients with recurrent aggressive fibromatosis. The cases were managed at a single private facility. A total of 9 patients with recurrent fibromatosis were included. The mean and median ages of the patients were 29 and 30 years, respectively. In total, two thirds (66.67%) of the cases were female. A negative previous medical history was reported in 7 cases (77.7%), and diabetes and hypertension were reported in 1 case (11.1%). Overall, only 1 case (11.1%) had a family history of breast fibromatosis. The time interval between primary tumor resection and recurrent presentation was 28 months. In 6 cases (66.7%), the tumor was located in the extremities. Pain was the most common presenting symptom in 6 cases (66.7%). All patients had their recurring tumor surgically removed, followed by radiation in 5 cases. The resection margin was positive in 4 cases (44.4%). Each patient was subjected to a careful three‑month follow‑up for recurrences. On the whole, the present study demonstrates that despite the fact that several therapeutic approaches for extra‑abdominal recurrent aggressive fibromatosis have been described in the literature, there is a significant likelihood of recurrence following resection.

Introduction

Fibromatosis, also termed desmoid tumor or aggressive fibromatosis (AF), is a clonal proliferative tumor that emerges from mesenchymal cells in the fascia and musculoaponeurotic structures and belongs to a small subset of soft tissue lesions (1,2). It is a rare soft tissue tumor that accounts for ~0.03% of all tumors and <3% of all soft tissue tumors, with a general population incidence of 2-4 per million individuals per year (3). Although the causes of this condition remain unclear, a connective tissue proliferation disease has been proposed as a possible cause. AF in adults has been linked to inherited diseases (Gardner's syndrome), pregnancy (particularly second pregnancy) and female sex hormones. However, these links do not apply to children (4). The majority of the cases are sporadic and genetically linked to Wnt/b-catenin pathway gene mutations, with a smaller percentage related to APC gene mutations (5). Syndromic cases are typically associated with intra-abdominal diseases and familial adenomatous polyposis (6). Regardless of the fact that fibromatosis does not metastasize and has a good survival prognosis, patients suffer significant morbidity as a result of the tumor's invasive progression and the possibility of a high recurrence rate ranging from 15 to 77% (6,7). The aim of the present study was to report a case series of extra-abdominal recurrent AF.

Patients and methods

Study design

The present study was a single-center retrospective case-series of patients with recurrent AF. The present study was approved by the Sulaimani University Ethics Committee (2023/no. 20). All patients or the parents of patients (for cases <18 years old) provided signed consent for their data to be published. The cases were managed at a single private facility. Throughout the previous 7 years (January 2016 to January 2023), the patients were evaluated, treated and followed-up.

Study participants

The socio-demographic and clinical data of the patients were obtained from the electronic health records of the Orthopedic Clinic at Smart Health Tower (Sulaimani, Iraq), which included age, sex, occupation, previous medical history, previous surgical history, smoking status, family history, radiation exposure history and a histopathological examination (Fig. 1), and details of the characteristics of primary and recurrent tumors.

For histopathological analysis, the sections (5-µm-thick) were paraffin-embedded and fixed with 10% neutral buffered formalin at room temperature for 24 h. The sections were then stained with hematoxylin and eosin (Bio Optica Co.) for 1-2 min at room temperature. They were then examined under a light microscope (Leica Microsystems GmbH).

Inclusion and exclusion criteria

The present study included all patients with extra-abdominal recurrent AF. Patients who do not return for follow-up are excluded from the study. An extensive literature review was performed to identify related articles. Studies published in predatory journals (not properly peer-reviewed) and those with minimal improvement or persistent symptoms were excluded. Predatory journals were defined according to Kscien's criteria (8).

Analysis of patient data

The data were collected and organized using Microsoft Excel 2019. The Statistical Package for Social Sciences 25.0 software (IBM Corp.) was used to qualitatively analyze (descriptive analysis) the data. The data are presented as frequencies, mean, median and range.

Results

A total of 9 patients with recurrent AF were included in the present study. The demographic data and clinical characteristics of the patients with primary tumors are presented in Table I. The patients varied in age from 7 to 60 years of age, with a mean and median age of 29 and 30 years, respectively. In total, two thirds of the cases (n=6; 66.67%) were female. A negative previous medical history was reported in 7 cases (77.7%), and diabetes and hypertension were reported in 1 case (11.1%); migraines were also reported in 1 case (11.1%). The previous surgical history was negative in 4 cases (44.4%), 2 cases had a history of cesarean section (22.2%), 1 case had a history of hemorrhoidectomy (11.1%), and another one had a history of pilonidal sinus disease. Overall, only 1 case (11.1%) had a family history of breast fibromatosis. The upper extremities were the site of primary tumors in 3 cases (33.3%), the lower extremities in 3 cases (33.3%), the chest wall in 2 cases (22.2%) and the lower back in 1 case (11.1%). The most common symptom of the primary tumors was pain at the tumor site (n=8; 88.9%). All primary tumors were surgically removed. In primary resection, the resection margin was positive in 3 cases (33.3%), negative in 2 cases (22.2%) and was undetermined in 4 cases (44.4%). Only 1 case (11.1%) of surgical site infection was reported. Following primary tumor excision, only 1 case (11.1%) underwent radiotherapy. Three cases with a positive resection margin did not undergo adjuvant radiotherapy, and as primary resection was not performed at Orthopedic Clinic at Smart Health Tower for these 3 cases (outpatients), the exact reason for this was not known (patients may have not agreed to this). Another case rejected adjuvant radiotherapy following recurrent resection.

Table I

The demographic data and clinical characteristics of the patients with primary tumors.

Table I

The demographic data and clinical characteristics of the patients with primary tumors.

Patient no.Age, yearsSexPMHPSHFHSitePresentationManagementSize of tumor (cm)Resection marginResidual tumor (R) classificationComplicationsRadiotherapy
127F-ve-ve-veLeft-side chest below axillaSevere left arm painExcision4+veR1-ve-ve
230M-vePNS-veUpper left chest wallUpper left side chest pain radiating to armExcision8+veR1-ve-ve
360FHTN, DMC/S, Hemorrhoidectomy-veMedial aspect of right legMild right leg pain and numbnessExcision9-veRxa-ve+ve
446FMigraine-ve-veLeft handMild left-hand pain, numbness, and weaknessExcision3UnknownRxa-ve-ve
514M-ve-veBreast fibromaLeft paraspinal (lumbar) areaMild back pain and swellingExcision3.4+veR2Infection-ve
630F-veC/S-veRight armRight arm pain, numbness, and ecchymosisExcision8UnknownR2-ve-ve
714M-veTonsillectomy-veLeft gluteal areaMild left gluteal painExcision6UnknownR2-ve-ve
87F-ve-ve-veRight gluteal areaSwellingExcisionN/A-veRxa-ve-ve
935FN/AN/AN/ADorsal aspect of right handSwellingExcisionN/AUnknownR1-ve-ve

[i] The age range of the patients was 7-60 years, the mean age was 29 years and the median age was 30 years.

[ii] aCould not be assessed due to fragmentation. PMH, previous medical history; PSH, previous surgical history; PNS, pilonidal sinus; FH, family history; -ve, negative; +ve, positive; HTN, hypertension; DM, diabetes mellitus; C/S, caesarean section; N/A, non-available.

The time interval between the primary tumor and the recurrent presentation was 28 months, ranging from 8 to 84 months. The clinical characteristics of patients with recurrent tumors are presented in Table II. In 6 cases (66.7%), the tumor was located in the upper and lower extremities, in 2 cases (22.2%) it was located in the chest, and in 1 case it was located (11.1%) in the back. Pain was the most common presenting symptom in 6 cases (66.7%), followed by a palpable mass in 3 cases (33.3%). The recurring tumor was completely surgically removed in all patients. The resection margin was positive in 4 cases (44.4%), negative in 2 cases (22.2%) and undetermined in the remaining cases. As regards the post-operative complications of recurring tumor resection, 1 patient (11.1%) had delayed wound healing, 1 patient (11.1%) had a surgical site infection and 1 patient (11.1%) had a femoral nerve injury. Following the removal of the recurrent tumor, 5 patients (55.6%) underwent radiation. Each patient was subjected to a careful 3-month follow-up for further recurrences. The follow-up of the cases revealed a good prognosis in all cases.

Table II

The clinical characteristics of patients with recurrent tumors.

Table II

The clinical characteristics of patients with recurrent tumors.

Patient no.Interval between primary and recurrence (months)Site of tumorPresentationManagementSize of tumor (cm)Resection marginResidual tumor (R) classificationRadiotherapyComplication
112Left infrascapular regionLeft arm painExcision7.6PositiveR2NoDelay wound healing
218Upper left chest wallSwellingExcision4.1NegativeR0YesNegative
330posterior aspect of right distal thigh and popliteal fossaSwellingExcisionN/AUnknownRxaNoSurgical site Infection
48Left handSevere left-hand pain, numbness and weaknessExcision4.5UnknownRxaYesNegative
512Left paraspinal (lumbar) areaMild back pain and massExcisionN/AUnknownR2NoNegative
648Right armRight arm pain, numbness, and ecchymosisExcision12PositiveR2YesNegative
784Left gluteal areaSwellingExcision9.5PositiveR2YesFemoral nerve injury
814Right gluteal areaSwellingExcision4.8NegativeRxaNoNegative
9UnknownDorsal aspect of right handPainful massExcision5PositiveR1YesNegative

[i] aCould not be assessed due to fragmentation.

Discussion

Under normal physiological conditions, fibroblasts play a critical role in the healing process and the preservation of vital organs, such as the lungs, liver, blood vessels, heart and kidneys; however, when specific cells acquire gene mutations, neoplasms can form, leading to the emergence of AF (9). The World Health Organization (WHO) defines AF as an intermediate soft tissue tumor with clonal fibroblastic proliferation originating from deep soft tissue and the potential to infiltrate locally (2). Fibromatoses are divided into three categories based on anatomic location: Intra-abdominal, abdominal wall and extra-abdominal (10). Extra-abdominal AFs are rare, slow-growing tumors with a varying biological behavior (4). The differentiation between intra-abdominal and extra-abdominal AFs is therapeutically essential due to variations in etiology, biological behavior and morbidity associated with surgical excision (6).

The peak incidence of AF occurs between the ages of 25 and 35 years, with a predominance observed in females (11). The most common symptom is a painless, growing mass; however, symptoms such as neurologic problems, joint stiffness, or gastrointestinal discomfort may also emerge as a result of tumor growth (9). Extra-abdominal head and neck lesions are more aggressive than other extra-abdominal lesions, resulting in significant bone damage and erosion of the base of the skull. They can occasionally expand to the trachea. Extra-abdominal tumors affecting the limbs may cause loss of function as a result of extensive resection, local recurrence and radiation therapy (4). This tumor is recognized as a highly unpredictable tumor with high rates of local recurrence (11). The time to relapse in the initial tumor varies from 8 to 23 months (median, 17.3 months), whereas the time to relapse in the recurrent tumor ranges from 3 to 26 months (median, 14.8 months) (12). In the present study, the female-to-male ratio was 3:1. Pain was the most prevalent presenting symptom in 66.7% of the cases, followed by a palpable mass in 33.3%. The mean interval from primary to recurrent presentation was 28 months.

Although computed tomography reveals the size of the tumor and its association with the neurovascular systems, magnetic resonance imaging (MRI) is the modality of choice for diagnosing and evaluating the extent of the tumor and the course of the disease following therapy. The features of an MRI vary. Heterogeneous variations are typical, depending on the collagen distribution and cellularity of the lesions. In both T1- and T2-weighted sequences, the lesions may be hypo- or hyper-intense compared to surrounding muscles or adipose tissues, with sharp or poorly demarcated margins (4,13). All patients in the present study were diagnosed and staged using MRI.

In recent years, urgent surgical therapy for extraperitoneal AF has not been recommended. According to the European Guidelines, the ‘watchful waiting’ strategy is the preferred therapy for asymptomatic AF (9,14). However, as the existence of the tumor is a pathological state in itself, some patients seek surgical therapy even when there are no obvious symptoms or disabilities caused by the tumor. AF can be treated with surgery, radiotherapy or chemotherapy; however, there is limited information available on the selection process for the appropriate treatment for each particular patient (15). In all age groups, full-margin surgical resection remains the treatment of choice for local tumor management. However, the invasive nature of AF renders complete removal difficult without compromising neighboring tissues, resulting in considerable functional impairment (3). Radiotherapy can be a successful therapeutic option, and it can be used as the only treatment for resected tumors with local recurrences, unresectable tumors and in individuals who refuse surgery. Radiotherapy has lately been established as a key therapeutic option for individuals who have relapsed following surgery (16). In the present study, all patients underwent complete tumor resection, followed by radiation in 5 cases.

Non-steroidal anti-inflammatory agents, such as indomethacin or sulindac, have either been utilized as single agents or in combination with anti-estrogens in the treatment of AF, with varying response rates reported based on limited series and case reports (4). Chemotherapy has infrequently been used due to the indolent and non-metastasizing nature of extra-abdominal AF. Agents such as doxorubicin, methotrexate, vincristine, dactinomycin, cyclophosphamide, vinblastine, hormonal therapies and kinase inhibitor drugs have all been documented with varying degrees of efficacy (17). According to a previous systematic review, cryoablation is an appropriate palliative therapeutic option as it is associated with a low risk of complications and delivers a long-term tumor response and symptom alleviation (18). High-intensity focused ultrasound is another therapeutic option that has exhibited immense potential as a treatment option for desmoid tumors. While it may have some adverse effects, it stands out for its precise removal capability and minimal invasiveness (19). However, further investigations are required to prove its effectiveness as a curative method. Furthermore, radiofrequency ablation is a minimally invasive treatment option commonly used to treat a number of benign lesions and unresectable malignant tumors by inserting a fine needle electrode into masses with imaging guidance. This treatment modality has also exhibited promising outcomes in several cases; however, it is associated with several side-effects, such as cellulitis and soft tissue necrosis (19).

To date, the patient's features and therapeutic results of recurrent fibromatosis have not been adequately addressed. In cases with recurrent pathology, surgical excision has been associated with a relatively high risk of re-recurrence of almost 90%, despite the fact that the chance of establishing a clean margin does not vary from the first surgical resection. The surgical margin quality following re-resection is unrelated to the frequency of relapse, presumably due to microscopic residual disease in the surgical bed after the original resection. Along with the high risk of failure, surgery continues to play a role in first-time recurrence; however, it does not appear to provide a meaningful benefit when patients return with subsequent recurrences (20).

Previous research has highlighted age, sex, tumor size, location and the surgical margin as key risk factors for surgical outcomes in patients with AF (21). Some researchers have demonstrated that certain genetic variables may be more predictive of AF recurrence as opposed to the resection margin quality (22). Timbergen et al (23) reported an association of the CTNNB1 mutation with surgical outcomes in an analysis of previously published studies and found that the S45F mutation was associated with an increased risk of local recurrence. Garvey et al (22) discovered that the 45F mutation was the only risk factor that was statistically predictive of recurrence. Although the S45F mutation appears to be related to a significant recurrence rate, it would be a weaker factor than the tumor site if included in the nomogram (15).

There is much debate over whether surgical resection margins have prognostic value for AF recurrence. Since AF is a very infiltrative tumor, assessing the margin status is relatively challenging (5). The previous study by Cates and Stricker (24) hypothesized that some ‘close but negative’ margins were definitely positive. They also found that a positive or near-positive (1 mm) resection margin was an independent predictor for local recurrence (24). Two recent studies with large patient populations yielded conflicting results. Zeng et al (25) studied patients with AF who had macroscopically complete resection, and found that the R1 resection status was a factor associated with poorer recurrence-free survival. Nevertheless, in the study by Crago et al (15), which included the largest cohort of patients with complete macroscopic resection, the margin status was not a predictor associated with recurrence.

According to a previous study, the microscopic negative margin state significantly affects the recurrence rate, and the recurrence rate is considerably reduced following full resection with negative margins for both original and recurrent tumors (6). These findings suggest that a full resection is the targeted outcome, and even recurrence rates in patients with a primary tumor are still very low following an R1 resection (6). By contrast, other previous large retrospective studies found no influence of the margin status on recurrence. However, these studies did not distinguish between intra-abdominal and extra-abdominal AF or account for varying adjuvant treatments (26,27). Age is also a significant predictive factor associated with the biological processes of AF. In their study, He et al (5) found that younger patients had a greater probability of local recurrence.

The location of the tumor is another factor associated with a greater likelihood of recurrence. It has been previously demonstrated that the extremities are an independent risk factor related to the local recurrence of AF (15). Tsagozis et al (20) also discovered that extremity lesions, particularly those of the lower extremities, had a greater probability of recurrence than trunk and pelvic lesions. This may be partially due to the proximity to neurovascular systems and the difficulty in achieving adequate resection margins in such locations (28). The majority of the patients (n=6; 66.7%) in the present study experienced AF of the extremities.

A larger tumor size is another debatable risk factor that has previously been identified. Several researchers have discovered that the size of the tumor increases the likelihood of recurrence (25). However, others have not found such an association (29). According to the study by Wang et al (9), a larger primary tumor size was related to a higher likelihood of recurrence and a shorter time to recurrence. Additionally, as larger lesions tended to infiltrate adjacent vessels and nerves, the lesion was not removed completely during surgery in order to protect local tissue function, and some tumor cells remained in the surrounding tissue, resulting in a short-term recurrence (9). Another study discovered that tumor size (5 or >5 cm) had a substantial effect on recurrence (10).

Adjuvant radiotherapy is a controversial subject in the treatment of AF since earlier research findings vary; some studies have found that radiation is related to improved local control of AF (25,30), while other scholars have found no effect (15). According to a previous study, adjuvant radiation appears to minimize the incidence of local recurrence following surgical resection with positive resection margins (6). Its efficacy in minimizing local recurrence is particularly prominent following the R1/R2 resection of recurrent AF and appears to have no additional benefit when surgical resection is complete at the time of the histological analysis (6). Guadagnolo et al (31) studied patients with primary and recurrent AF in whom adjuvant radiation obtained a 10-year local control rate of 78%. In their systematic review, Yao et al (32) concluded that surgery plus adjuvant radiation decreased recurrence compared to surgery alone. Adjuvant radiation was thus suggested for all patients, even those with negative resection margins (32). Radiotherapy with doses ≥60 Gy has been demonstrated to enhance local control rates by 80 to 88% (31).

Moreover, several studies have found that radiation efficacy is associated with margin status (6,33,34). A previous study found that in patients with positive margins, post-operative adjuvant radiation enhanced local control and lowered the recurrence rate compared to surgery alone (33). A previous meta-analysis found that although adjuvant radiation was not effective for patients with negative margins, it may enhance local control and prevent recurrence in individuals with inadequate resection (6). The National Comprehensive Cancer Network (NCCN) guidelines recommend adjuvant radiation for patients with R1 resection and definitive radiotherapy for those with R2 resection (34). The apparent limitations of the present study were the small sample size, the lack of a genetic profile of patients to identify the role of genetic factors in disease emergence and the lack of any explanation regarding the etiology of the cases.

In conclusion, fibromatosis is a rare, locally invasive fibroblastic tumor with no metastatic potential. Despite the fact that several therapeutic approaches have been described in the literature, there is a significant likelihood of recurrence following resection. Further studies are thus required to further determine the management and risks of recurrence.

Acknowledgements

Not applicable.

Funding

Funding: No funding was received.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Authors' contributions

SKA provided major contributions to the study concept and the final approval of the manuscript. FHK and MNH were involved in the literature review, in the design of the study, and in the writing of the manuscript. AMA was the histopathologist who examined the specimen. SAA, SHT, CSO, RJR, FHF, BAA and SHM were involved in critically revising the manuscript and in data interpretation. All authors have read and approved the final manuscript. SAA and SKA confirm the authenticity of all the raw data. All authors agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Ethics approval and consent

The present study was approved by the Sulaimani University Ethics Committee (2023/no. 20). All patients or the parents of patients (for cases <18 years old) provided signed consent for their data to be published.

Patient consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

References

1 

Machado V, Troncoso S, Mejías L, Idoate MÁ and San-Julián M: Risk factors for local recurrence of fibromatosis. Rev Esp Cir Ortop Traumatol. 61:82–87. 2017.PubMed/NCBI View Article : Google Scholar : (In English, Spanish).

2 

Hammood ZD, Salih AM, Kakamad FH, Abdullah AM, Ali BS and Pshtiwan LR: Desmoid fibromatosis of the breast; a rare case report. Int J Surg Case Rep. 87(106363)2021.PubMed/NCBI View Article : Google Scholar

3 

Eastley N, Aujla R, Silk R, Richards CJ, McCulloch TA, Esler CP and Ashford RU: Extra-abdominal desmoid fibromatosis-a sarcoma unit review of practice, long term recurrence rates and survival. Eur J Surg Oncol. 40:1125–1130. 2014.PubMed/NCBI View Article : Google Scholar

4 

Papagelopoulos PJ, Mavrogenis AF, Mitsiokapa EA, Papaparaskeva KT, Galanis EC and Soucacos PN: Current trends in the management of extra-abdominal desmoid tumours. World J Surg Oncol. 4(21)2006.PubMed/NCBI View Article : Google Scholar

5 

He XD, Zhang YB, Wang L, Tian ML, Liu W, Qu Q, Li BL, Hong T, Li NC and Na YQ: Prognostic factors for the recurrence of sporadic desmoid-type fibromatosis after macroscopically complete resection: Analysis of 114 patients at a single institution. Eur J Surg Oncol. 41:1013–1019. 2015.PubMed/NCBI View Article : Google Scholar

6 

Janssen ML, Van Broekhoven DL, Cates JM, Bramer WM, Nuyttens JJ, Gronchi A, Salas S, Bonvalot S, Grünhagen DJ and Verhoef C: Meta-analysis of the influence of surgical margin and adjuvant radiotherapy on local recurrence after resection of sporadic desmoid-type fibromatosis. Br J Surg. 104:347–357. 2017.PubMed/NCBI View Article : Google Scholar

7 

Molloy AP, Hutchinson B and O'toole GC: Extra-abdominal desmoid tumours: A review of the literature. Sarcoma. 2012(578052)2012.PubMed/NCBI View Article : Google Scholar

8 

Muhialdeen AS, Ahmed JO, Baba HO, Abdullah IY, Hassan HA, Najar KA, Mikael TM, Mustafa MQ, Mohammed DA, et al: Kscien's List; A New Strategy to Discourage Predatory Journals and Publishers (Second Version). Barw Med J. 1:1–3. 2023.

9 

Wang J, Huang Y, Sun Y, Ge Y and Zhang M: Value of imaging findings in predicting post-operative recurrence of desmoid-type fibromatosis. Oncol Lett. 19:869–875. 2020.PubMed/NCBI View Article : Google Scholar

10 

Niu X, Jiang R and Hu C: Radiotherapy in the treatment of primary or recurrent unresectable desmoid tumors of the neck. Cancer Invest. 37:387–392. 2019.PubMed/NCBI View Article : Google Scholar

11 

Sedaghat S, Sedaghat M, Krohn S, Jansen O, Freund K, Streitbürger A and Reichardt B: Long-term diagnostic value of MRI in detecting recurrent aggressive fibromatosis at two multidisciplinary sarcoma centers. Eur J Radiol. 134(109406)2021.PubMed/NCBI View Article : Google Scholar

12 

Wang YF, Guo W, Sun KK, Yang RL, Tang XD, Ji T and Tang S: Postoperative recurrence of desmoid tumors: Clinical and pathological perspectives. World J Surg Oncol. 13(26)2015.PubMed/NCBI View Article : Google Scholar

13 

Braschi-Amirfarzan M, Keraliya AR, Krajewski KM, Tirumani SH, Shinagare AB, Hornick JL, Baldini EH, George S, Ramaiya NH and Jagannathan JP: Role of imaging in management of desmoid-type fibromatosis: A primer for radiologists. Radiographics. 36:767–782. 2016.PubMed/NCBI View Article : Google Scholar

14 

Eastley N, McCulloch T, Esler C, Hennig I, Fairbairn J, Gronchi A and Ashford R: Extra-abdominal desmoid fibromatosis: A review of management, current guidance and unanswered questions. Eur J Surg Oncol. 42:1071–1083. 2016.PubMed/NCBI View Article : Google Scholar

15 

Crago AM, Denton B, Salas S, Dufresne A, Mezhir JJ, Hameed M, Gonen M, Singer S and Brennan MF: A prognostic nomogram for prediction of recurrence in desmoid fibromatosis. Ann Surg. 258:347–253. 2013.PubMed/NCBI View Article : Google Scholar

16 

Choi SH, Yoon HI, Kim SH, Kim SK, Shin KH and Suh CO: Optimal radiotherapy strategy for primary or recurrent fibromatosis and long-term results. PLoS One. 13(e0198134)2018.PubMed/NCBI View Article : Google Scholar

17 

Wood TJ, Quinn KM, Farrokhyar F, Deheshi B, Corbett T and Ghert MA: Local control of extra-abdominal desmoid tumors: Systematic review and meta-analysis. Rare Tumors. 5(e2)2013.PubMed/NCBI View Article : Google Scholar

18 

Vora BMK, Munk PL, Somasundaram N, Ouellette HA, Mallinson PI, Sheikh A, Abdul Kadir H, Tan TJ and Yan YY: Cryotherapy in extra-abdominal desmoid tumors: A systematic review and meta-analysis. PLoS One. 16(e0261657)2021.PubMed/NCBI View Article : Google Scholar

19 

Zhang Z, Shi J, Yang T, Liu T and Zhang K: Management of aggressive fibromatosis. Oncol Lett. 21(43)2021.PubMed/NCBI View Article : Google Scholar

20 

Tsagozis P, Stevenson JD, Grimer R and Carter S: Outcome of surgery for primary and recurrent desmoid-type fibromatosis. A retrospective case series of 174 patients. Ann Med Surg (Lond). 17:14–19. 2017.PubMed/NCBI View Article : Google Scholar

21 

Nishida Y, Hamada S, Kawai A, Kunisada T, Ogose A, Matsumoto Y, Matsumoto Y, Ae K, Toguchida J, Ozaki T, et al: Risk factors of local recurrence after surgery in extraabdominal desmoid-type fibromatosis: A multicenter study in Japan. Cancer Sci. 111:2935–2942. 2020.PubMed/NCBI View Article : Google Scholar

22 

Garvey PB, Booth JH, Baumann DP, Calhoun KA, Liu J, Pollock RE and Butler CE: Complex reconstruction of desmoid tumor resections does not increase desmoid tumor recurrence. J Am Coll Surg. 217:472–480. 2013.PubMed/NCBI View Article : Google Scholar

23 

Timbergen MJM, Colombo C, Renckens M, Kim HS, Rosmalen JV, Salas S, Mullen JT, Colombo P, Nishida Y, Wiemer EAC, et al: The prognostic role of β-catenin mutations in desmoid-type fibromatosis undergoing resection only: A meta-analysis of individual patient data. Ann Surg. 273:1094–1101. 2021.PubMed/NCBI View Article : Google Scholar

24 

Cates JM and Stricker TP: Surgical resection margins in desmoid-type fibromatosis: A critical reassessment. Am J Surg Pathol. 38:1707–1714. 2014.PubMed/NCBI View Article : Google Scholar

25 

Zeng WG, Zhou ZX, Liang JW, Hou HR, Wang Z, Zhou HT, Zhang XM and Hu JJ: Prognostic factors for desmoid tumor: A surgical series of 233 patients at a single institution. Tumour Biol. 35:7513–7521. 2014.PubMed/NCBI View Article : Google Scholar

26 

Salas S, Dufresne A, Bui B, Blay JY, Terrier P, Ranchere-Vince D, Bonvalot S, Stoeckle E, Guillou L, Le Cesne A, et al: Prognostic factors influencing progression-free survival determined from a series of sporadic desmoid tumors: A wait-and-see policy according to tumor presentation. J Clin Oncol. 29:3553–3558. 2011.PubMed/NCBI View Article : Google Scholar

27 

Gronchi A, Colombo C, Le Péchoux C, Dei Tos AP, Le Cesne A, Marrari A, Penel N, Grignani G, Blay JY, Casali PG, et al: Sporadic desmoid-type fibromatosis: A stepwise approach to a non-metastasising neoplasm-a position paper from the Italian and the French Sarcoma Group. Ann Oncol. 25:578–583. 2014.PubMed/NCBI View Article : Google Scholar

28 

Horsley M, Arshad MS and Khan T: Fibromatosis: A review of the risk factors for recurrence and outcomes. Acta Orthop Belg 86 e-supplement. 1:55–60. 2020.

29 

Peng PD, Hyder O, Mavros MN, Turley R, Groeschl R, Firoozmand A, Lidsky M, Herman JM, Choti M, Ahuja N, et al: Management and recurrence patterns of desmoids tumors: A multi-institutional analysis of 211 patients. Ann Surg Oncol. 19:4036–4042. 2012.PubMed/NCBI View Article : Google Scholar

30 

Gluck I, Griffith KA, Biermann JS, Feng FY, Lucas DR and Ben-Josef E: Role of radiotherapy in the management of desmoid tumors. Int J Radiat Oncol Biol Phys. 80:787–792. 2011.PubMed/NCBI View Article : Google Scholar

31 

Guadagnolo BA, Zagars GK and Ballo MT: Long-term outcomes for desmoid tumors treated with radiation therapy. Int J Radiat Oncol Biol Phys. 71:441–447. 2008.PubMed/NCBI View Article : Google Scholar

32 

Yao X, Corbett T, Gupta AA, Kandel RA, Verma S, Werier J and Ghert M: A systematic review of active treatment options in patients with desmoid tumours. Curr Oncol. 21:e613–e629. 2014.PubMed/NCBI View Article : Google Scholar

33 

Mullen JT, DeLaney TF, Kobayashi WK, Szymonifka J, Yeap BY, Chen YL, Rosenberg AE, Harmon DC, Choy E, Yoon SS, et al: Desmoid tumor: Analysis of prognostic factors and outcomes in a surgical series. Ann Surg Oncol. 19:4028–4035. 2012.PubMed/NCBI View Article : Google Scholar

34 

Yang T, Liu H, Liao Z, Zhang C, Xiang L and Yang J: Postoperative adjuvant radiotherapy can delay the recurrence of desmoid tumors After R0 resection in certain subgroups. Front Surg. 8(697793)2021.PubMed/NCBI View Article : Google Scholar

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October-2023
Volume 19 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Asaad SK, Abdullah AM, Abdalrahman SA, Fattah FH, Tahir SH, Omer CS, Rashid RJ, Hassan MN, Mohammed SH, Kakamad FH, Kakamad FH, et al: Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review. Mol Clin Oncol 19: 84, 2023.
APA
Asaad, S.K., Abdullah, A.M., Abdalrahman, S.A., Fattah, F.H., Tahir, S.H., Omer, C.S. ... Abdalla, B.A. (2023). Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review. Molecular and Clinical Oncology, 19, 84. https://doi.org/10.3892/mco.2023.2680
MLA
Asaad, S. K., Abdullah, A. M., Abdalrahman, S. A., Fattah, F. H., Tahir, S. H., Omer, C. S., Rashid, R. J., Hassan, M. N., Mohammed, S. H., Kakamad, F. H., Abdalla, B. A."Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review". Molecular and Clinical Oncology 19.4 (2023): 84.
Chicago
Asaad, S. K., Abdullah, A. M., Abdalrahman, S. A., Fattah, F. H., Tahir, S. H., Omer, C. S., Rashid, R. J., Hassan, M. N., Mohammed, S. H., Kakamad, F. H., Abdalla, B. A."Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review". Molecular and Clinical Oncology 19, no. 4 (2023): 84. https://doi.org/10.3892/mco.2023.2680