Open Access

Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review

  • Authors:
    • Saywan K. Asaad
    • Ari M. Abdullah
    • Shkar Ali Abdalrahman
    • Fattah H. Fattah
    • Soran H. Tahir
    • Choman Sabah Omer
    • Rezheen J. Rashid
    • Marwan N. Hassan
    • Shvan H. Mohammed
    • Fahmi H. Kakamad
    • Berun A. Abdalla
  • View Affiliations

  • Published online on: September 7, 2023     https://doi.org/10.3892/mco.2023.2680
  • Article Number: 84
  • Copyright: © Asaad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aggressive fibromatosis is a rare clonal proliferative tumor arising from mesenchymal cells in the fascia and musculoaponeurotic structures. The aim of the present study was to describe several cases of extra‑abdominal recurrent aggressive fibromatosis. The present study was a single‑center retrospective case series of patients with recurrent aggressive fibromatosis. The cases were managed at a single private facility. A total of 9 patients with recurrent fibromatosis were included. The mean and median ages of the patients were 29 and 30 years, respectively. In total, two thirds (66.67%) of the cases were female. A negative previous medical history was reported in 7 cases (77.7%), and diabetes and hypertension were reported in 1 case (11.1%). Overall, only 1 case (11.1%) had a family history of breast fibromatosis. The time interval between primary tumor resection and recurrent presentation was 28 months. In 6 cases (66.7%), the tumor was located in the extremities. Pain was the most common presenting symptom in 6 cases (66.7%). All patients had their recurring tumor surgically removed, followed by radiation in 5 cases. The resection margin was positive in 4 cases (44.4%). Each patient was subjected to a careful three‑month follow‑up for recurrences. On the whole, the present study demonstrates that despite the fact that several therapeutic approaches for extra‑abdominal recurrent aggressive fibromatosis have been described in the literature, there is a significant likelihood of recurrence following resection.
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October-2023
Volume 19 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Asaad SK, Abdullah AM, Abdalrahman SA, Fattah FH, Tahir SH, Omer CS, Rashid RJ, Hassan MN, Mohammed SH, Kakamad FH, Kakamad FH, et al: Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review. Mol Clin Oncol 19: 84, 2023.
APA
Asaad, S.K., Abdullah, A.M., Abdalrahman, S.A., Fattah, F.H., Tahir, S.H., Omer, C.S. ... Abdalla, B.A. (2023). Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review. Molecular and Clinical Oncology, 19, 84. https://doi.org/10.3892/mco.2023.2680
MLA
Asaad, S. K., Abdullah, A. M., Abdalrahman, S. A., Fattah, F. H., Tahir, S. H., Omer, C. S., Rashid, R. J., Hassan, M. N., Mohammed, S. H., Kakamad, F. H., Abdalla, B. A."Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review". Molecular and Clinical Oncology 19.4 (2023): 84.
Chicago
Asaad, S. K., Abdullah, A. M., Abdalrahman, S. A., Fattah, F. H., Tahir, S. H., Omer, C. S., Rashid, R. J., Hassan, M. N., Mohammed, S. H., Kakamad, F. H., Abdalla, B. A."Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review". Molecular and Clinical Oncology 19, no. 4 (2023): 84. https://doi.org/10.3892/mco.2023.2680