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Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen

  • Authors:
    • Bowen Hu
    • Minbo Yan
    • Shuchang Huang
    • Hui Liang
    • Wenfei Lian
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The People's Hospital of Longhua, Shenzhen, Guangdong 518000, P.R. China, Department of Urology, The Fifth Affiliated Hospital of Sun Yat‑sen University, Zhuhai, Guangdong 519000, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 10
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    Published online on: December 12, 2023
       https://doi.org/10.3892/mco.2023.2708
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Abstract

There is evidence that the systemic inflammatory response may have an impact on prostate‑specific antigen (PSA) levels. However, the relationship between the platelet‑to‑lymphocyte ratio (PLR) and PSA remains unclear. As a result, the relationship between PLR and PSA using the National Health and Nutrition Examination Survey (NHANES) database was examined. After the screening, 6,638 participants out of 52,186 in the NHANES survey conducted between 2001 to 2010 were suitable for the present study. The PLR was the independent variable in the present study, and PSA was the dependent variable. The selected subjects in the present study had an average age of 58.563±11.848 years. After controlling for covariates, the results showed that with every increase in PLR, the PSA concentration increased by 0.004 ng/ml (0.001, 0.007). This difference was statistically significant. Furthermore, a smoothing curve based on a fully adjusted model was created to investigate the possibility of a linear relationship between PLR and PSA concentration in men from USA. In men from USA, an independent and positive correlation between PLR and PSA was identified, which could potentially result in overdiagnosis of asymptomatic prostate cancer in populations with higher PLR levels.
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Copy and paste a formatted citation
Spandidos Publications style
Hu B, Yan M, Huang S, Liang H and Lian W: Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen. Mol Clin Oncol 20: 10, 2024.
APA
Hu, B., Yan, M., Huang, S., Liang, H., & Lian, W. (2024). Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen. Molecular and Clinical Oncology, 20, 10. https://doi.org/10.3892/mco.2023.2708
MLA
Hu, B., Yan, M., Huang, S., Liang, H., Lian, W."Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen". Molecular and Clinical Oncology 20.2 (2024): 10.
Chicago
Hu, B., Yan, M., Huang, S., Liang, H., Lian, W."Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen". Molecular and Clinical Oncology 20, no. 2 (2024): 10. https://doi.org/10.3892/mco.2023.2708
Copy and paste a formatted citation
x
Spandidos Publications style
Hu B, Yan M, Huang S, Liang H and Lian W: Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen. Mol Clin Oncol 20: 10, 2024.
APA
Hu, B., Yan, M., Huang, S., Liang, H., & Lian, W. (2024). Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen. Molecular and Clinical Oncology, 20, 10. https://doi.org/10.3892/mco.2023.2708
MLA
Hu, B., Yan, M., Huang, S., Liang, H., Lian, W."Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen". Molecular and Clinical Oncology 20.2 (2024): 10.
Chicago
Hu, B., Yan, M., Huang, S., Liang, H., Lian, W."Association between platelet‑to‑lymphocyte ratio and serum prostate specific antigen". Molecular and Clinical Oncology 20, no. 2 (2024): 10. https://doi.org/10.3892/mco.2023.2708
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