Open Access

Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review)

  • Authors:
    • Stella Baliou
    • Maria Adamaki
    • Petros Ioannou
    • Aglaia Pappa
    • Mihalis I. Panayiotidis
    • Ioannis Christodoulou
    • Demetrios A. Spandidos
    • Anthony M. Kyriakopoulos
    • Vassilis Zoumpourlis
  • View Affiliations

  • Published online on: May 31, 2021     https://doi.org/10.3892/mi.2021.3
  • Article Number: 3
  • Copyright : © Baliou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

To develop novel therapeutic methods for both diabetic and renal disorders, scientists had initially focused on elucidating the molecular mechanisms of taurine in established cell lines and mouse models. Although a large amount of data have been revealed, taurine has been confirmed to be the next step of novel promising therapeutic interventions against diabetic disorders. Taurine appears to ameliorate diabetes 1‑related complications in various organs through its antioxidant, anti‑inflammatory and anti‑hormonal actions. In type 2 diabetes, taurine has been positively implicated in glucose homeostasis, exerting potent hypoglycemic, anti‑obesity, hypotensive and hypolipidemic effects. Of particular interest is that taurine provides protection against renal dysfunction, including hypertension and proteinuria, specific glomerular and tubular disorders, acute and chronic renal conditions, and diabetic nephropathy. The ameliorative effects of taurine against renal disorders are based on its osmoregulatory properties, its association with signaling pathways and its association with the renin‑angiotensin‑aldosterone system (RAAS). Further clinical studies are required to ensure the importance of research findings.

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May-June 2021
Volume 1 Issue 2

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Spandidos Publications style
Baliou S, Adamaki M, Ioannou P, Pappa A, Panayiotidis MI, Christodoulou I, Spandidos DA, Kyriakopoulos AM and Zoumpourlis V: Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review). Med Int 1: 3, 2021
APA
Baliou, S., Adamaki, M., Ioannou, P., Pappa, A., Panayiotidis, M.I., Christodoulou, I. ... Zoumpourlis, V. (2021). Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review). Medicine International, 1, 3. https://doi.org/10.3892/mi.2021.3
MLA
Baliou, S., Adamaki, M., Ioannou, P., Pappa, A., Panayiotidis, M. I., Christodoulou, I., Spandidos, D. A., Kyriakopoulos, A. M., Zoumpourlis, V."Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review)". Medicine International 1.2 (2021): 3.
Chicago
Baliou, S., Adamaki, M., Ioannou, P., Pappa, A., Panayiotidis, M. I., Christodoulou, I., Spandidos, D. A., Kyriakopoulos, A. M., Zoumpourlis, V."Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review)". Medicine International 1, no. 2 (2021): 3. https://doi.org/10.3892/mi.2021.3