Open Access

Early diagnosis of cerebral vasospasm associated with cerebral ischemia following subarachnoid hemorrhage: Evaluation of computed tomography perfusion and transcranial doppler as accurate methods

  • Authors:
    • Vasiliki Tsolaki
    • Aikaterini Aravantinou‑fatorou
    • Vasiliki Epameinondas Georgakopoulou
    • Demetrios A. Spandidos
    • Petros Papalexis
    • Nikolaos Mathioudakis
    • Kyriakos Tarantinos
    • Nikolaos Trakas
    • Pagona Sklapani
    • George Fotakopoulos
  • View Affiliations

  • Published online on: November 2, 2022     https://doi.org/10.3892/mi.2022.59
  • Article Number: 34
  • Copyright: © Tsolaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cerebral vasospasm (CV) constitutes a major post‑operative complication and source of morbidity in cases of subarachnoid hemorrhage (SAH). The early detection of CV in SAH may be difficult both clinically and radiographically. The present pilot study thus aimed to evaluate the practicability of the technique in a tertiary healthcare setting and to assess the diagnostic effectiveness of various diagnostic computed tomography (CT) perfusion (CTP) aspects in predicting the clinical outcome of patients with SAH (traumatic and aneurysmal). A retrospective study including 34 patients in a tertiary care hospital was thus conducted. The results revealed that of the 34 patients, 18 (52.9%) were males, and the mean age was 54.4±18.5 years (16‑85 years old; range, 69 years). In total, 15 (44.1%) patients had traumatic SAH following traumatic brain injury (TBI), 11 (33.3%) had aneurysmal SAH, and 8 patients (23.6%) presented with TBI without SAH as controls. CTP was performed on the third to the sixth day, and 15‑20 min prior to CPT, a transcranial Doppler ultrasound was performed. Clinical outcomes were documented at 30 days using a CT scan and a complete neurological evaluation, including Glasgow Coma Scale assessment. The results of a multivariate analysis revealed that cerebral blood flow (CBF) was an independent factor for detecting an ischemic event in 1 month (P=0.003). On the whole, the present study demonstrates that CTP, and consequently CBF, is a considerable index that may identify the onset of cerebral ischemia in patients with SAH.

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November-December 2022
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Spandidos Publications style
Tsolaki V, Aravantinou‑fatorou A, Georgakopoulou VE, Spandidos DA, Papalexis P, Mathioudakis N, Tarantinos K, Trakas N, Sklapani P, Fotakopoulos G, Fotakopoulos G, et al: Early diagnosis of cerebral vasospasm associated with cerebral ischemia following subarachnoid hemorrhage: Evaluation of computed tomography perfusion and transcranial doppler as accurate methods. Med Int 2: 34, 2022
APA
Tsolaki, V., Aravantinou‑fatorou, A., Georgakopoulou, V.E., Spandidos, D.A., Papalexis, P., Mathioudakis, N. ... Fotakopoulos, G. (2022). Early diagnosis of cerebral vasospasm associated with cerebral ischemia following subarachnoid hemorrhage: Evaluation of computed tomography perfusion and transcranial doppler as accurate methods. Medicine International, 2, 34. https://doi.org/10.3892/mi.2022.59
MLA
Tsolaki, V., Aravantinou‑fatorou, A., Georgakopoulou, V. E., Spandidos, D. A., Papalexis, P., Mathioudakis, N., Tarantinos, K., Trakas, N., Sklapani, P., Fotakopoulos, G."Early diagnosis of cerebral vasospasm associated with cerebral ischemia following subarachnoid hemorrhage: Evaluation of computed tomography perfusion and transcranial doppler as accurate methods". Medicine International 2.6 (2022): 34.
Chicago
Tsolaki, V., Aravantinou‑fatorou, A., Georgakopoulou, V. E., Spandidos, D. A., Papalexis, P., Mathioudakis, N., Tarantinos, K., Trakas, N., Sklapani, P., Fotakopoulos, G."Early diagnosis of cerebral vasospasm associated with cerebral ischemia following subarachnoid hemorrhage: Evaluation of computed tomography perfusion and transcranial doppler as accurate methods". Medicine International 2, no. 6 (2022): 34. https://doi.org/10.3892/mi.2022.59