Open Access

Diagnosis of manganism and manganese neurotoxicity: A workshop report

  • Authors:
    • Donald R. Mattison
    • Franco Momoli
    • Cemil Alyanak
    • Michael Aschner
    • Marissa Baker
    • Neil Cashman
    • Ulrike Dydak
    • Nawal Farhat
    • Tomás R. Guilarte
    • Nataliya Karyakina
    • Siva Ramoju
    • Natalia Shilnikova
    • Pille Taba
    • Daniel Krewski
  • View Affiliations

  • Published online on: February 6, 2024     https://doi.org/10.3892/mi.2024.135
  • Article Number: 11
  • Copyright : © Mattison et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

With declining exposures to manganese (Mn) in occupational settings, there is a need for more sensitive exposure assessments and clinical diagnostic criteria for manganism and Mn neurotoxicity. To address this issue, a workshop was held on November 12‑13, 2020, with international experts on Mn toxicity. The workshop discussions focused on the history of the diagnostic criteria for manganism, including those developed by the Institut de Recherche Robert‑Sauvé en Santé et en Sécurité du Travail (IRSST) in Quebec in 2005 and criteria developed by the Chinese government in 2002 and updated in 2006; the utility of biomarkers of exposure; recent developments in magnetic resonance imaging (MRI) for assessing Mn accumulation in the brain and diagnosing manganism; and potential future applications of metabolomics. The suggestions of the participants for updating manganism diagnostic criteria included the consideration of: i) A history of previous occupational and environmental exposure to Mn; ii) relevant clinical symptoms such as dystonia; iii) MRI imaging to document Mn accumulation in the neural tissues, including the basal ganglia; and iv) criteria for the differential diagnosis of manganism and other neurological conditions. Important research gaps include the characterization of Mn exposure and other co‑exposures, exploration of the roles of different brain regions with MRI, understanding the complexity of metal ion transporters involved in Mn homeostasis, and a need for information on other neurotransmitter systems and brain regions underlying the pathophysiology of manganism.
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Spandidos Publications style
Mattison DR, Momoli F, Alyanak C, Aschner M, Baker M, Cashman N, Dydak U, Farhat N, Guilarte TR, Karyakina N, Karyakina N, et al: Diagnosis of manganism and manganese neurotoxicity: A workshop report. Med Int 4: 11, 2024
APA
Mattison, D.R., Momoli, F., Alyanak, C., Aschner, M., Baker, M., Cashman, N. ... Krewski, D. (2024). Diagnosis of manganism and manganese neurotoxicity: A workshop report. Medicine International, 4, 11. https://doi.org/10.3892/mi.2024.135
MLA
Mattison, D. R., Momoli, F., Alyanak, C., Aschner, M., Baker, M., Cashman, N., Dydak, U., Farhat, N., Guilarte, T. R., Karyakina, N., Ramoju, S., Shilnikova, N., Taba, P., Krewski, D."Diagnosis of manganism and manganese neurotoxicity: A workshop report". Medicine International 4.2 (2024): 11.
Chicago
Mattison, D. R., Momoli, F., Alyanak, C., Aschner, M., Baker, M., Cashman, N., Dydak, U., Farhat, N., Guilarte, T. R., Karyakina, N., Ramoju, S., Shilnikova, N., Taba, P., Krewski, D."Diagnosis of manganism and manganese neurotoxicity: A workshop report". Medicine International 4, no. 2 (2024): 11. https://doi.org/10.3892/mi.2024.135