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Comment Open Access

Diagnosis of manganism and manganese neurotoxicity: A workshop report

  • Authors:
    • Donald R. Mattison
    • Franco Momoli
    • Cemil Alyanak
    • Michael Aschner
    • Marissa Baker
    • Neil Cashman
    • Ulrike Dydak
    • Nawal Farhat
    • Tomás R. Guilarte
    • Nataliya Karyakina
    • Siva Ramoju
    • Natalia Shilnikova
    • Pille Taba
    • Daniel Krewski
  • View Affiliations / Copyright

    Affiliations: Risk Sciences International, Ottawa, ON K1P 5J6, Canada, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada, School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA, Department of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA, Department of Neurology and Neurosurgery, Institute of Clinical Medicine, University of Tartu, 50406 Tartu, Estonia
    Copyright: © Mattison et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 11
    |
    Published online on: February 6, 2024
       https://doi.org/10.3892/mi.2024.135
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Abstract

With declining exposures to manganese (Mn) in occupational settings, there is a need for more sensitive exposure assessments and clinical diagnostic criteria for manganism and Mn neurotoxicity. To address this issue, a workshop was held on November 12‑13, 2020, with international experts on Mn toxicity. The workshop discussions focused on the history of the diagnostic criteria for manganism, including those developed by the Institut de Recherche Robert‑Sauvé en Santé et en Sécurité du Travail (IRSST) in Quebec in 2005 and criteria developed by the Chinese government in 2002 and updated in 2006; the utility of biomarkers of exposure; recent developments in magnetic resonance imaging (MRI) for assessing Mn accumulation in the brain and diagnosing manganism; and potential future applications of metabolomics. The suggestions of the participants for updating manganism diagnostic criteria included the consideration of: i) A history of previous occupational and environmental exposure to Mn; ii) relevant clinical symptoms such as dystonia; iii) MRI imaging to document Mn accumulation in the neural tissues, including the basal ganglia; and iv) criteria for the differential diagnosis of manganism and other neurological conditions. Important research gaps include the characterization of Mn exposure and other co‑exposures, exploration of the roles of different brain regions with MRI, understanding the complexity of metal ion transporters involved in Mn homeostasis, and a need for information on other neurotransmitter systems and brain regions underlying the pathophysiology of manganism.
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1 

Couper J: On the effects of black oxide of manganese when inhaled into the lungs. Br Ann Med Pharmacol. 1:41–42. 1837.

2 

Aschner JL, Anderson A, Slaughter JC, Aschner M, Steele S, Beller A, Mouvery A, Furlong HM and Maitre NL: Neuroimaging identifies increased manganese deposition in infants receiving parenteral nutrition. Am J Clin Nutr. 102:1482–1489. 2015.PubMed/NCBI View Article : Google Scholar

3 

Stepens A, Groma V, Skuja S, Platkājis A, Aldiņš P, Ekšteina I, Mārtiņsone I, Bricis R and Donaghy M: The outcome of the movement disorder in methcathinone abusers: Clinical, MRI and manganesemia changes, and neuropathology. Eur J Neurol. 21:199–205. 2014.PubMed/NCBI View Article : Google Scholar

4 

Anagianni S and Tuschl K: Genetic disorders of manganese metabolism. Curr Neurol Neurosci Rep. 19(33)2019.PubMed/NCBI View Article : Google Scholar

5 

da Silva CJ, da Rocha AJ, Jeronymo S, Mendes MF, Milani FT, Maia AC Jr, Braga FT, Sens YA and Miorin LA: A preliminary study revealing a new association in patients undergoing maintenance hemodialysis: Manganism symptoms and T1 hyperintense changes in the basal ganglia. AJNR Am J Neuroradiol. 28:1474–1479. 2007.PubMed/NCBI View Article : Google Scholar

6 

Tuschl K, Clayton PT, Gospe SM Jr, Gulab S, Ibrahim S, Singhi P, Aulakh R, Ribeiro RT, Barsottini OG, Zaki MS, et al: Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man. Am J Hum Genet. 90:457–466. 2012.PubMed/NCBI View Article : Google Scholar

7 

Taba P: Metals and movement disorders. Curr Opin Neurol. 26:435–441. 2013.PubMed/NCBI View Article : Google Scholar

8 

Racette BA: Manganism in the 21st century: The Hanninen lecture. Neurotoxicology. 45:201–207. 2014.PubMed/NCBI View Article : Google Scholar

9 

Racette BA, Gross A, Criswell SR, Checkoway H and Searles Nielsen S: A screening tool to detect clinical manganese neurotoxicity. Neurotoxicology. 64:12–18. 2018.PubMed/NCBI View Article : Google Scholar

10 

Myers JE, Fine J, Ormond-Brown D, Rice J, Thomson A and Thompson ML: Estimating the prevalence of clinical manganism using a cascaded screening process in a South African manganese smelter. Neurotoxicology. 30:934–940. 2009.PubMed/NCBI View Article : Google Scholar

11 

IRSST: Management of Occupational Management of Occupational Manganism Consensus of an Experts' Panel. Report R 417, 2005. Available at: https://www.irsst.qc.ca/media/documents/pubirsst/r-417.pdf.

12 

Ministry of Health of the People's Republic of China: Diagnostic Criteria for Occupational Chronic Manganese Poisoning. GBZ 3-2006, March 2006. Available at https://niohp.chinacdc.cn/zyysjk/zywsbzml/201301/P020130105471460363503.pdf (Translated from the original Chinese work with Google Translate).

13 

Rutchik JS, Zheng W, Jiang Y and Mo X: How does an occupational neurologist assess welders and steelworkers for a manganese-induced movement disorder? An international team's experiences in Guanxi, China, part I. J Occup Environ Med. 54:1432–1434. 2012.PubMed/NCBI View Article : Google Scholar

14 

Calne DB, Chu NS, Huang CC, Lu CS and Olanow W: Manganism and idiopathic parkinsonism: similarities and differences. Neurology. 44:1583–1586. 1994.PubMed/NCBI View Article : Google Scholar

15 

Olanow CW: Manganese-induced parkinsonism and Parkinson's disease. Ann NY Acad Sci. 1012:209–223. 2004.PubMed/NCBI View Article : Google Scholar

16 

Huang CC: Parkinsonism induced by chronic manganese intoxication-an experience in Taiwan. Chang Gung Med J. 30:385–395. 2007.PubMed/NCBI

17 

Kim Y: Neuroimaging in manganism. Neurotoxicology. 27:369–372. 2006.PubMed/NCBI View Article : Google Scholar

18 

Jankovic J: Searching for a relationship between manganese and welding and Parkinson's disease. Neurology. 64:2021–2028. 2005.PubMed/NCBI View Article : Google Scholar

19 

Santamaria AB, Cushing CA, Antonini JM, Finley BL and Mowat FS: State-of-the-science review: Does manganese exposure during welding pose a neurological risk? J Toxicol Environ Health B Crit Rev. 10:417–465. 2007.PubMed/NCBI View Article : Google Scholar

20 

Karyakina NA, Shilnikova N, Farhat N, Ramoju S, Cline B, Momoli F, Mattison D, Jensen N, Terrell R and Krewski D: Biomarkers for occupational manganese exposure. Crit Rev Toxicol. 52:636–663. 2022.PubMed/NCBI View Article : Google Scholar

21 

Shilnikova N, Karyakina N, Farhat N, Ramoju S, Cline B, Momoli F, Mattison D, Jensen N, Terrell R and Krewski D: Biomarkers of environmental manganese exposure. Crit Rev Toxicol. 52:325–343. 2022.PubMed/NCBI View Article : Google Scholar

22 

Balachandran RC, Yanko FM, Cheng P, Prince LM, Rivers CN, Morcillo P, Akinyemi AJ, Tabbassum S, Pfalzer AC, Nie LH, et al: Rodent hair is a Poor biomarker for internal manganese exposure. Food Chem Toxicol. 157(112555)2021.PubMed/NCBI View Article : Google Scholar

23 

Ward EJ, Edmondson DA, Nour MM, Snyder S, Rosenthal FS and Dydak U: Toenail manganese: A sensitive and specific biomarker of exposure to manganese in career welders. Ann Work Expo Health. 62:101–111. 2017.PubMed/NCBI View Article : Google Scholar

24 

Ward E, Bowler R, Nour M, Snyder S, Rosenthal F and Dydak U: Exposure to metal mixtures in welding fume: Effects on neuropsychological functions. Toxicol Sci Suppl. 150(1596)2016.

25 

Baker MG, Simpson CD, Stover B, Sheppard L, Checkoway H, Racette BA and Seixas NS: Blood manganese as an exposure biomarker: State of the evidence. J Occup Environ Hyg. 11:210–217. 2014.PubMed/NCBI View Article : Google Scholar

26 

Hoet P and Roels HA (eds): Significance and Usefulness of Biomarkers of Exposure to Manganese. Vol 22. Royal Society of Chemistry, pp355-401, 2015.

27 

Park RM: Neurobehavioral deficits and parkinsonism in occupations with manganese exposure: A review of methodological issues in the epidemiological literature. Saf Health Work. 4:123–135. 2013.PubMed/NCBI View Article : Google Scholar

28 

Zheng W, Fu SX, Dydak U and Cowan DM: Biomarkers of manganese intoxication. Neurotoxicology. 32:1–8. 2011.PubMed/NCBI View Article : Google Scholar

29 

Gutiérrez-González E, García-Esquinas E, de Larrea-Baz NF, Salcedo-Bellido I, Navas-Acien A, Lope V, Gómez-Ariza JL, Pastor R, Pollán M and Pérez-Gómez B: Toenails as biomarker of exposure to essential trace metals: A review. Environ Res. 179(108787)2019.PubMed/NCBI View Article : Google Scholar

30 

O'Neal SL and Zheng W: Manganese toxicity upon overexposure: A decade in review. Curr Environ Health Rep. 2:315–328. 2015.PubMed/NCBI View Article : Google Scholar

31 

Baker MG, Simpson CD, Sheppard L, Stover B, Morton J, Cocker J and Seixas N: Variance components of short-term biomarkers of manganese exposure in an inception cohort of welding trainees. J Trace Elem Med Biol. 29:123–129. 2015.PubMed/NCBI View Article : Google Scholar

32 

Hoet P, Vanmarcke E, Geens T, Deumer G, Haufroid V and Roels HA: Manganese in plasma: A promising biomarker of exposure to Mn in welders. A pilot study. Toxicol Lett. 213:69–74. 2012.PubMed/NCBI View Article : Google Scholar

33 

Edmondson DA, Ma RE, Yeh CL, Ward E, Snyder S, Azizi E, Zauber SE, Wells EM and Dydak U: Reversibility of neuroimaging markers influenced by lifetime occupational manganese exposure. Toxicol Sci. 172:181–190. 2019.PubMed/NCBI View Article : Google Scholar

34 

Long Z, Jiang YM, Li XR, Fadel W, Xu J, Yeh CL, Long LL, Luo HL, Harezlak J, Murdoch JB, et al: Vulnerability of welders to manganese exposure-a neuroimaging study. Neurotoxicology. 45:285–292. 2014.PubMed/NCBI View Article : Google Scholar

35 

Yeh C, Johnson C, Ma R, Dharmadhikari S, Snyder S and Dydak U: Whole-Brain Visualization of Manganese Deposition in Welders. Proc Intl Mag Reson Med. 25(3047)2017.

36 

Bowler RM, Yeh CL, Adams SW, Ward EJ, Ma RE, Dharmadhikari S, Snyder SA, Zauber SE, Wright CW and Dydak U: Association of MRI T1 relaxation time with neuropsychological test performance in manganese-exposed welders. Neurotoxicology. 64:19–29. 2018.PubMed/NCBI View Article : Google Scholar

37 

Ma RE, Ward EJ, Yeh CL, Snyder S, Long Z, Gokalp Yavuz F, Zauber SE and Dydak U: Thalamic GABA levels and occupational manganese neurotoxicity: Association with exposure levels and brain MRI. Neurotoxicology. 64:30–42. 2018.PubMed/NCBI View Article : Google Scholar

38 

Baker MG, Criswell SR, Racette BA, Simpson CD, Sheppard L, Checkoway H and Seixas NS: Neurological outcomes associated with low-level manganese exposure in an inception cohort of asymptomatic welding trainees. Scand J Work Environ Health. 41:94–101. 2015.PubMed/NCBI View Article : Google Scholar

39 

Criswell SR, Perlmutter JS, Huang JL, Golchin N, Flores HP, Hobson A, Aschner M, Erikson KM, Checkoway H and Racette BA: Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders. Occup Environ Med. 69:437–443. 2012.PubMed/NCBI View Article : Google Scholar

40 

Jensen N, Terrell R, Ramoju S, Shilnikova N, Farhat N, Karyakina N, Cline BH, Momoli F, Mattison D and Krewski D: Magnetic resonance imaging T1 indices of the brain as biomarkers of inhaled manganese exposure. Crit Rev Toxicol. 52:358–370. 2022.PubMed/NCBI View Article : Google Scholar

41 

Wishart DS: Computational approaches to metabolomics. Methods Mol Biol. 593:283–313. 2010.PubMed/NCBI View Article : Google Scholar

42 

Baker MG, Simpson CD, Lin YS, Shireman LM and Seixas N: The Use of Metabolomics to Identify Biological Signatures of Manganese Exposure. Ann Work Expo Health. 61:406–415. 2017.PubMed/NCBI View Article : Google Scholar

43 

Carter KA, Simpson CD, Raftery D and Baker MG: Short report: Using targeted urine metabolomics to distinguish between manganese exposed and unexposed workers in a small occupational cohort. Front Public Health. 9(666787)2021.PubMed/NCBI View Article : Google Scholar

44 

Baker MG, Lin YS, Simpson CD, Shireman LM, Searles Nielsen S, Racette BA and Seixas N: The reproducibility of urinary ions in manganese exposed workers. J Trace Elem Med Biol. 51:204–211. 2019.PubMed/NCBI View Article : Google Scholar

45 

Baker MG, Stover B, Simpson CD, Sheppard L and Seixas NS: Using exposure windows to explore an elusive biomarker: Blood manganese. Int Arch Occup Environ Health. 89:679–687. 2016.PubMed/NCBI View Article : Google Scholar

46 

WHO: Manganese. Environmental Health Criteria 17. World Health Organization, 1981.

47 

Zoni S, Albini E and Lucchini R: Neuropsychological testing for the assessment of manganese neurotoxicity: A review and a proposal. Am J Ind Med. 50:812–830. 2007.PubMed/NCBI View Article : Google Scholar

48 

Ruhf RC: Control of manganese dust and fume exposures at a ferromanganese production and processing facility. J Occup Med. 20:626–628. 1978.PubMed/NCBI View Article : Google Scholar

49 

Rodier J: Manganese poisoning in Moroccan miners. Br J Ind Med. 12:21–35. 1955.PubMed/NCBI View Article : Google Scholar

50 

DeWitt MR, Chen P and Aschner M: Manganese efflux in Parkinsonism: Insights from newly characterized SLC30A10 mutations. Biochem Biophys Res Commun. 432:1–4. 2013.PubMed/NCBI View Article : Google Scholar

51 

Quadri M, Kamate M, Sharma S, Olgiati S, Graafland J, Breedveld GJ, Kori I, Hattiholi V, Jain P, Aneja S, et al: Manganese transport disorder: Novel SLC30A10 mutations and early phenotypes. Mov Disord. 30:996–1001. 2015.PubMed/NCBI View Article : Google Scholar

52 

Asser A, Hikima A, Raki M, Bergström K, Rose S, Juurmaa J, Krispin V, Muldmaa M, Lilles S, Rätsep H, et al: Subacute administration of both methcathinone and manganese causes basal ganglia damage in mice resembling that in methcathinone abusers. J Neural Transm (Vienna). 127:707–714. 2020.PubMed/NCBI View Article : Google Scholar

53 

Sikk K and Taba P: Methcathinone ‘Kitchen Chemistry’ and permanent neurological damage. Int Rev Neurobiol. 120:257–271. 2015.PubMed/NCBI View Article : Google Scholar

54 

Marti-Sanchez L, Ortigoza-Escobar JD, Darling A, Villaronga M, Baide H, Molero-Luis M, Batllori M, Vanegas MI, Muchart J, Aquino L, et al: Hypermanganesemia due to mutations in SLC39A14: Further insights into Mn deposition in the central nervous system. Orphanet J Rare Dis. 13(28)2018.PubMed/NCBI View Article : Google Scholar

55 

Peres TV, Schettinger MR, Chen P, Carvalho F, Avila DS, Bowman AB and Aschner M: Manganese-induced neurotoxicity: A review of its behavioral consequences and neuroprotective strategies. BMC Pharmacol Toxicol. 17(57)2016.PubMed/NCBI View Article : Google Scholar

56 

Lee EY, Flynn MR, Du G, Lewis MM, Fry R, Herring AH, Van Buren E, Van Buren S, Smeester L, Kong L, et al: T1 Relaxation Rate (R1) Indicates Nonlinear Mn accumulation in brain tissue of welders with low-level exposure. Toxicol Sci. 146:281–289. 2015.PubMed/NCBI View Article : Google Scholar

57 

Criswell SR, Nielsen SS, Warden MN, Flores HP, Lenox-Krug J, Racette S, Sheppard L, Checkoway H and Racette BA: MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers. J Occup Environ Med. 61:641–645. 2019.PubMed/NCBI View Article : Google Scholar

58 

Fechter LD, Johnson DL and Lynch RA: The relationship of particle size to olfactory nerve uptake of a non-soluble form of manganese into brain. Neurotoxicology. 23:177–183. 2002.PubMed/NCBI View Article : Google Scholar

59 

Schraufnagel DE: The health effects of ultrafine particles. Exp Mol Med. 52:311–317. 2020.PubMed/NCBI View Article : Google Scholar

60 

Hobson A, Seixas N, Sterling D and Racette BA: Estimation of particulate mass and manganese exposure levels among welders. Ann Occup Hyg. 55:113–125. 2011.PubMed/NCBI View Article : Google Scholar

61 

Kim Y, Bowler RM, Abdelouahab N, Harris M, Gocheva V and Roels HA: Motor function in adults of an Ohio community with environmental manganese exposure. Neurotoxicology. 32:606–614. 2011.PubMed/NCBI View Article : Google Scholar

62 

Pavilonis BT, Lioy PJ, Guazzetti S, Bostick BC, Donna F, Peli M, Zimmerman NJ, Bertrand P, Lucas E, Smith DR, et al: Manganese concentrations in soil and settled dust in an area with historic ferroalloy production. J Expo Sci Environ Epidemiol. 25:443–450. 2015.PubMed/NCBI View Article : Google Scholar

63 

Rodichkin AN, Edler MK, McGlothan JL and Guilarte TR: Behavioral and neurochemical studies of inherited manganese-induced dystonia-parkinsonism in Slc39a14-knockout mice. Neurobiol Dis. 158(105467)2021.PubMed/NCBI View Article : Google Scholar

64 

Stefani A, Pierantozzi M, Olivola E, Galati S, Cerroni R, D'Angelo V, Hainsworth AH, Saviozzi V, Fedele E and Liguori C: Homovanillic acid in CSF of mild stage Parkinson's disease patients correlates with motor impairment. Neurochem Int. 105:58–63. 2017.PubMed/NCBI View Article : Google Scholar

65 

Ai LB, Chua LH, New AL, Lee BL, Liu YM, Chia SE and Ong CN: Urinary homovanillic acid (HVA) and vanillymandelic acid (VMA) in workers exposed to manganese dust. Biol Trace Elem Res. 64:89–99. 1998.PubMed/NCBI View Article : Google Scholar

66 

Guilarte TR and Gonzales KK: Manganese-Induced parkinsonism is not idiopathic Parkinson's disease: Environmental and genetic evidence. Toxicol Sci. 146:204–212. 2015.PubMed/NCBI View Article : Google Scholar

67 

Vermeulen R: The use of high-resolution metabolomics in occupational exposure and health research. Ann Work Expo Health. 61:395–397. 2017.PubMed/NCBI View Article : Google Scholar

68 

Chen P, Totten M, Zhang Z, Bucinca H, Erikson K, Santamaría A, Bowman AB and Aschner M: Iron and manganese-related CNS toxicity: Mechanisms, diagnosis and treatment. Expert Rev Neurother. 19:243–260. 2019.PubMed/NCBI View Article : Google Scholar

69 

Roth JA and Garrick MD: Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol. 66:1–13. 2003.PubMed/NCBI View Article : Google Scholar

70 

Ye Q, Park JE, Gugnani K, Betharia S, Pino-Figueroa A and Kim J: Influence of iron metabolism on manganese transport and toxicity. Metallomics. 9:1028–1046. 2017.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Mattison DR, Momoli F, Alyanak C, Aschner M, Baker M, Cashman N, Dydak U, Farhat N, Guilarte TR, Karyakina N, Karyakina N, et al: Diagnosis of manganism and manganese neurotoxicity: A workshop report. Med Int 4: 11, 2024.
APA
Mattison, D.R., Momoli, F., Alyanak, C., Aschner, M., Baker, M., Cashman, N. ... Krewski, D. (2024). Diagnosis of manganism and manganese neurotoxicity: A workshop report. Medicine International, 4, 11. https://doi.org/10.3892/mi.2024.135
MLA
Mattison, D. R., Momoli, F., Alyanak, C., Aschner, M., Baker, M., Cashman, N., Dydak, U., Farhat, N., Guilarte, T. R., Karyakina, N., Ramoju, S., Shilnikova, N., Taba, P., Krewski, D."Diagnosis of manganism and manganese neurotoxicity: A workshop report". Medicine International 4.2 (2024): 11.
Chicago
Mattison, D. R., Momoli, F., Alyanak, C., Aschner, M., Baker, M., Cashman, N., Dydak, U., Farhat, N., Guilarte, T. R., Karyakina, N., Ramoju, S., Shilnikova, N., Taba, P., Krewski, D."Diagnosis of manganism and manganese neurotoxicity: A workshop report". Medicine International 4, no. 2 (2024): 11. https://doi.org/10.3892/mi.2024.135
Copy and paste a formatted citation
x
Spandidos Publications style
Mattison DR, Momoli F, Alyanak C, Aschner M, Baker M, Cashman N, Dydak U, Farhat N, Guilarte TR, Karyakina N, Karyakina N, et al: Diagnosis of manganism and manganese neurotoxicity: A workshop report. Med Int 4: 11, 2024.
APA
Mattison, D.R., Momoli, F., Alyanak, C., Aschner, M., Baker, M., Cashman, N. ... Krewski, D. (2024). Diagnosis of manganism and manganese neurotoxicity: A workshop report. Medicine International, 4, 11. https://doi.org/10.3892/mi.2024.135
MLA
Mattison, D. R., Momoli, F., Alyanak, C., Aschner, M., Baker, M., Cashman, N., Dydak, U., Farhat, N., Guilarte, T. R., Karyakina, N., Ramoju, S., Shilnikova, N., Taba, P., Krewski, D."Diagnosis of manganism and manganese neurotoxicity: A workshop report". Medicine International 4.2 (2024): 11.
Chicago
Mattison, D. R., Momoli, F., Alyanak, C., Aschner, M., Baker, M., Cashman, N., Dydak, U., Farhat, N., Guilarte, T. R., Karyakina, N., Ramoju, S., Shilnikova, N., Taba, P., Krewski, D."Diagnosis of manganism and manganese neurotoxicity: A workshop report". Medicine International 4, no. 2 (2024): 11. https://doi.org/10.3892/mi.2024.135
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