Adrenergic receptor system as a pharmacological target in the treatment of epilepsy (Review)
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- Published online on: February 27, 2024 https://doi.org/10.3892/mi.2024.144
- Article Number: 20
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Copyright : © Ozdemir . This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Abstract
Introduction
Epilepsy is a brain disorder characterized by recurrent seizures, which is diagnosed in 4 to 10 out of every 1,000 individuals in developed countries and affects 75 million individuals worldwide (1-3). The etiology of epileptic disorders is complex and may be of genetic, developmental or acquired origin (4,5). There is a balance between excitatory and inhibitory synaptic mediators [glutamate and gamma-aminobutyric acid (GABA)] in the healthy brain, and a shift of this balance towards excitation is considered the primary cause of epilepsy (6). In addition, serotonergic receptors (7,8), neuroinflammation (9-11), nitric oxide pathway (12) and various ion channels, such as calcium ions (13) may also play a critical role in the mechanism of epilepsy.
There is ample evidence to indicate that the noradrenergic system plays a key role in the regulation of epileptogenesis and convulsions (14,15). Norepinephrine (NE) is generally synthesized and released from noradrenergic nerve endings in the locus coeruleus (LC) (16,17). Abnormal NE secretion causes an increase in tonic/clonic seizures in mice genetically prone to epileptic seizures (18). Although the LC is a small brainstem nucleus, it is the sole source of NE in the neocortex, hippocampus and cerebellum. NE is a potent neuromodulator involved in regulating the excitability of large-scale brain regions. NE concentrations have been reported to increase at seizure onset and decrease during or shortly following the seizure (19).
The inhibition of NE release by gabapentin and pregabalin has an anticonvulsant effect. These drugs exert their effects by binding to the α2δ subunit of voltage-sensitive Ca2+ channels. Similarly, gabapentin and pregabalin cause a decrease in NE release through an increase in the extracellular K+ concentration (20). In another study, blocking voltage-sensitive Ca2+ channels with melatonin exerted an anti-epileptic effect by inhibiting NE release (21). In addition, the density of adrenergic receptors (ARs) in various brain areas decreases during seizures (22,23). NE exerts a pronounced suppressive effect on the development of epileptic seizures. Consistent with this, a decrease in the NE concentration or the administration of AR antagonists causes an increase in the frequency of seizures (24,25). However, there is evidence to suggest that increased NE levels under certain conditions activate seizures, possibly via different ARs (15,26,27). Furthermore, exposure to specific β2-adrenergic agonist drugs poses a significant risk for epilepsy (28). Conversely, the β-AR antagonist, propranolol, has been shown to reduce pentylenetetrazole (PTZ)-induced tonic/clonic seizures (29).
The hippocampus plays a crucial role in the pathogenesis of epilepsy and the activation of the α1A-AR increases the inhibitory tone in the CA1 region of the hippocampus (30). Selective α1A-AR activation increases action potential firing in a subpopulation of hippocampal CA1 interneurons. In response to this, Na+ influx is initiated independently of second messenger signaling. In addition, α1A-AR activation decreases activity due to increased pre-synaptic GABA in CA1 pyramidal cells (30). Furthermore, blockade of the α1B adrenoceptor subtype exerts both neuroprotective and anti-epileptic effects (31).
The α2-adrenoceptor subtype has been reported to modulate seizure susceptibility in different seizure patterns. For example, α2-adrenoceptor agonist, clonidine, has been shown to suppress the development of PTZ-induced seizures (32,33). By contrast, the α2-adrenoceptor antagonist, yohimbine, has been found to have proconvulsive properties at relatively high doses in the PTZ-induced seizure model (34). Using the α2-adrenoceptor pathway, lithium chloride exhibits anticonvulsant properties in the PTZ-induced clonic seizure model (35). Adenosine exerts antiepileptic activity in animals by increasing the seizure threshold induced by PTZ through α2-adrenoceptors (36). The β-AR is distributed in the central nervous system (CNS), particularly in the amygdala (37). The decreased expression of β-AR in the amygdala of epileptic animals leads to facilitating seizures (38).
Evidently, the activation of different ARs leads to complex effects on epileptic seizures that have not yet been fully elucidated. In the present review, the role of the adrenergic system in epilepsy and the therapeutic potential of AR agonists are discussed.
2. Adrenergic receptor types and subtypes
ARs are membrane-bound G protein-coupled receptors (GPCRs) that mediate the peripheral and central effects of NE. ARs are first divided into two major groups: α- and β-ARs (39). In recent years, the development of new pharmacological tools has revealed nine different subtypes of ARs: Three α1-ARs (α1A, α1B and α1D), three α2-ARs (α2A/D, α2B and α2C) and three β-ARs (β1, β2 and β3) (40) (Fig. 1).
In total, three subtypes of α1-AR have been identified in the CNS, and α1A-ARs are the most abundant (~55%) receptor type. The α1B- (35%) and α1D (10%) subtype receptors exhibit a lower distribution (41-43). In particular, α1-ARs are abundantly isolated in neurons of the thalamus and cortex, and in interneurons containing GABA (44). α1A-AR has a more widespread distribution than α1B-AR in the entorhinal cortex and amygdala. Of note, α1A-AR is also detected in the cortex, but not in a homogeneous distribution (41). Both α1-AR subtypes have been demonstrated in similar cell types, such as neurons, interneurons and progenitors (45,46). Experimental research has demonstrated that α1A-AR activation by phenylephrine can significantly reduce hyperexcitability in the hippocampal CA1 region via GABAA receptors (33).
α2-ARs have been shown to have both presynaptic and postsynaptic functions. The α2A-AR is the main inhibitory presynaptic receptor that regulates NE release from sympathetic neurons as part of a feedback loop (40,47). However, in some tissues, α2C-ARs are considered to be inhibitory presynaptic receptors (48). α2B-ARs are located on postsynaptic cells and mediate the vasoconstrictive effects of catecholamines released from sympathetic nerves (39).
β-ARs are essential components of the sympathetic nervous system and belong to the superfamily of GPCRs (49). Subsequently, adenylate cyclase (AC) activation causes an increase in cAMP, the main modulator of intracellular events (50). β1-AR subtypes constitute 70-80% of cardiac β-ARs (49). β2-ARs are mostly found in airway smooth muscle. In addition, β2-AR are detected in alveolar type II cells, uterine muscle, mast cells, mucous glands, skeletal muscle, epithelial cells and vascular endothelium (51).
β3-ARs are abundantly found in adipose tissue and participate in the regulation of lipolysis and thermogenesis. It has been shown that some β3 agonists have anti-stress effects. This suggests that β3-ARs also play a role in the CNS. Furthermore, β3-ARs have been found in the urinary bladder, gallbladder and brown adipose tissue (52). β3-ARs are Gs-type G protein receptors and are involved in norepinephrine-induced AC activation (53).
3. Effects of α1-adrenergic receptors on epilepsy
Changes in α1A-AR intensity have been found in animals with seizures (54,55) and in patients with epilepsy (22). α1A-ARs are usually found in postsynaptic neurons and are activated by NE (56). The activation of these receptors specifically inhibits seizures of the limbic system (57). In general, the activation of α-ARs attenuates the rate of epileptiform discharges (58). α1-ARs frequently increase the activity of GABAergic interneurons, and GABA released from interneurons plays a key role in the inhibitory effects of these receptors (59,60). By contrast, the overactivity of α1B-AR causes spontaneous epileptic seizures in mice overexpressing α1B-AR (61), while a deficiency in α1B-AR results in the reduction of pilocarpine-induced seizures (31) (Table I) (30,31,62-73).
In the prefrontal cortex, α1B-ARs are also expressed in both glutamatergic pyramidal cells and GABAergic interneurons (74). The stimulation of α1-ARs depolarizes GABAergic interneurons, resulting in enhanced GABAergic transmission in prefrontal cortex cells (75). In addition, the activation of the α1A-AR subtype by NE also causes the depolarization of hippocampal CA1 interneurons (30). These interneurons are GABAergic and express the neuropeptide somatostatin, and when activated, somatostatin is released to nearby pyramidal neurons. Moreover, the stimulation of α1A-AR by NE increases the pre-synaptic release of GABA and somatostatin, thereby reducing CA1 pyramidal activity (76). Furthermore, new pyrrolidin-2-one derivatives with affinity for α1-ARs cause a decrease in seizure susceptibility by exhibiting GABAergic activity (77). In addition, it has been shown that seizures originating from the medial prefrontal cortex and caused by acute stress are induced by NE stimulation of α1-ARs (65). Electrophysiological recordings have revealed that NE promotes epileptiform activity induction through α1-AR stimulation in medial prefrontal cortex pyramidal cells. Similarly, α1D-AR antagonism decreases hippocampal glutamate levels and produces potent anticonvulsant effects (78). By contrast, α1A-AR stimulation suppresses epileptiform activity in hippocampal interneurons (30).
4. Effects of α2-adrenergic receptors on epilepsy
α2A-ARs are widely distributed in various brain regions, and their activation suppresses the epileptiform activity of areas associated with seizure formation, such as the amygdala (79) and hippocampus (59). Different study data have revealed conflicting results regarding the effects of α2 agonists on epileptic seizures. Some data report proconvulsant (27), while others anticonvulsant effects (66,80). In different areas of the brain, α2A- and α2C-ARs function as both pre- and post-synaptic receptors. It exerts the proconvulsant effects of α2-AR agonists through presynaptic α2-ARs (81). These agonists reduce NE release in noradrenergic neuron terminals (82). However, the anticonvulsant effect of α2-ARs occurs as a result of the released NE activating postsynaptic receptors in target neurons (83). There is also evidence to suggest that post-synaptic α2A-receptors are primarily responsible for the anticonvulsant effect of α2-adrenoreceptor agonists (59,70). The anticonvulsant mechanism of action of NE is briefly summarized in Fig. 2.
Increasing extracellular hippocampal dopamine and GABA secretions plays a critical role in the anticonvulsant effect of the NE reuptake inhibitor maprotiline. Moreover, the anticonvulsant effect of maprotiline is potentiated by the administration of a selective α2- and β2-agonists. On the other hand, α1D receptor agonists reduce the anticonvulsant effect (78). The α2-AR selective agonist, dexmedetomidine, exerts anticonvulsant effects on PTZ-induced seizures, whereas the α2-AR antagonist ATI facilitates epileptic seizures in rats (66). Furthermore, dexmedetomidine significantly reduced the number of c-Fos positive cells in the rat brain (66). However, another study demonstrated a pro-epileptic effect of dexmedetomidine in spike-wave epilepsy in WAG/Rij rats (84). In previous a study on the rat hippocampus, the α2-AR antagonist was implicated in the NE-mediated anti-epileptic effect in the CA3 domain (85). Electrical brain stimulation in the rat hippocampus exerts an inhibitory effect on epileptiform activity via α1 and α2 ARs (86,87). Moreover, the α2-AR agonist, yohimbine, and adenosine provide an additive effect to increase the seizure threshold induced by pentylenetetrazole in mice (36). Experimental evidence has revealed that the specific cannabinoid CB1 agonist, ACEA, is involved in its anticonvulsant properties by functionally interacting with α2-adrenoceptors in PTZ-induced seizures in mice (32).
The effects of α2-AR agonists on epileptic seizure activity vary depending on the dose. Clonidine, an α2-AR agonist, exerts anticonvulsant effects at high doses, while it is proconvulsant at low doses (88). The difference in this effect may be partly related to the different signaling pathways initiated by the activation of α2-ARs. The dose of α2A agonist used and the adenylate cyclase isoform found in different neurons can determine this effect (89).
5. Effects of β-adrenergic receptors on epilepsy
Β-ARs are low affinity receptors for NE and are activated during periods of intense LC activation with a high NE release. The prolonged stimulation of β-ARs leads to a decrease in their sensitivity (90). β-AR is extensively distributed in the amygdala (37). Long-term antidepressant treatment downregulates β-receptors in the amygdala and leads to an increase in epileptic seizures in rats (24). Similarly, reductions in the concentration of β-ARs in the amygdala of epileptic animals may contribute to facilitating seizures (38). The administration of β2-AR agonists to mice also causes a reduction in PTZ-induced seizures (82). In addition, the β2-agonist, salbutamol, has been shown to exhibit anti-epileptic activity in maximal electroshock-induced seizures in mice (91).
The role of β-ARs in epileptic seizure susceptibility is largely unclear, and there are conflicting findings in different studies. An increase in seizures may be an expected result in studies using β-AR blockers (92). By contrast, there are different studies demonstrating that β-AR antagonists exert anticonvulsant effects in various animal models of seizures (93,94). The non-selective β-AR antagonist, propranolol, exerts an anticonvulsant effect by blocking the sodium channel rather than its hippocampal effects (95). However, it is stated that a similar mechanism is responsible for the anticonvulsant effect of clenbuterol, which is a β2-AR agonist (1). Moreover, the stimulation of β2-ARs reduces limbic seizures by increasing hippocampal dopamine levels (78). The α-receptor antagonist, phentolamine, selectively reduces anticonvulsant effects, while the β-receptor antagonist, timolol, blocks proconvulsant activity (96). These results suggest that there are different mechanisms in seizure formation in various animal models. Nevertheless, these results clearly indicate that β2-AR activation plays a critical role in the anticonvulsant effect of NE.
6. Adrenergic modulation of GABA and glutamate
NE exerts excitatory and inhibitory effects on neuronal excitability, depending on receptor subtypes and locations. However, there is evidence to suggest that the dominant effect of NE suppresses excitability in a number of brain regions (83,97). It is a known fact that the pathogenesis of epileptic seizures is associated with the hyperexcitability of brain neurons. Therefore, it is important that NE reduces excitability in its anti-epileptic effect. The effect of NE on neuronal excitability may be via modulation of the conductivity of ion channels or indirectly, usually through GABAergic and glutamatergic transmission (83). Evidence has shown that activating the noradrenergic system facilitates the presynaptic release of GABA (68). In addition, GABA induces NE release by activating GABAA receptors at noradrenergic nerve terminals (98). NE has the ability to alter the excitability of GABAergic cells in certain brain regions (99). For example, the chronic use of certain antidepressant drugs (e.g., citalopram and fluoxetine) that increase NE levels causes the downregulation of ARs and GABAA receptors (100). This regulation may be one of the possible reasons for the proconvulsant effect of chronic antidepressant therapy. The activation of a1-ARs can cause epileptic seizures by increasing GABAergic transmission in various brain limbic regions, including the hippocampus (101), piriform cortex (100) and amygdala (102). The activation of α1-ARs through a decrease in potassium conductivity decreases epileptic seizures in the hippocampus by depolarizing inhibitory interneurons (30,101). In a previous study on the medial prefrontal cortex, it was found that the stimulation of α1-ARs with phenylephrine facilitated GABAergic transmission to pyramidal neurons (75).
Numerous noradrenergic neurons from the LC make synaptic connections with GABAergic interneurons in the basolateral amygdala. Through the activation of α1-ARs, NE depolarizes GABAergic interneurons in the amygdala and increases GABA transmission. This causes the inhibition of pyramidal glutamatergic cells (103). Stress suppresses NE-mediated GABAergic transmission. Therefore, it is suggested that this is a possible mechanism underlying the increase in stress-induced seizure activity (102). A significant association has been found between the decrease in the density of α2-ARs in the amygdala of mice and epileptic seizures (64).
There is evidence to suggest strong associations between the adrenergic and glutamatergic systems in the brain. NE secretion also exerts prominent effects on the neuronal excitatory glutamate system (104). NE plays a key role in regulating the sensitivity of specific postsynaptic glutamate receptors (105). It has been stated that ionotropic glutamate receptors play a critical role in the regulation of NE release, and the activation of glutamate receptors reduces NE levels in the rat hippocampus (104). An increase in glutamatergic activity in the entorhinal cortex leads to the induction of seizures. However, the administration of NE blocks seizure activity in this area (105). NE increases epileptiform activity in the hippocampal dentate gyrus (DG) through N-methyl-D-aspartate (NMDA) receptor activation (106). A significant downregulation in β1-ARs sensitivity in the DG can reduce the stimulating effect of NE and may thus prevent seizures (105). Furthermore, the epileptic seizures observed in transgenic mice overexpressing α1B-AR are considered to result from an increased NMDA receptor number via α1B-ARs (107).
7. Conclusion and future perspectives
There is ample evidence to suggest that the endogenous neuromediator, NE, is involved in the modulation of different types of epileptic seizures. Depending on the activated AR subtype and brain region, NE sometimes has an anti-convulsant and sometimes a convulsant effect. In addition, NE may modulate seizures through affecting various neurotransmitter systems, particularly GABA and glutamate, or voltage-gated Ca2+ and/or K+ channels. The seizure activity control activity of NE may be impaired in some cases of increased susceptibility to seizures, such as exposure to high levels of NE due to stress. The results of various studies demonstrated that abnormal increases or decreases in NE levels in the brain may cause an impairment in NE-related functions, which may contribute to an increased seizure susceptibility. In conclusion, recent data indicate that the activation of α1-, α2- and β2-AR subtypes with selective receptor agonists produces anticonvulsant effects in epileptic seizures. Fully elucidating the effects of AR subtypes on epileptic seizures may be an important target for the pharmacological treatment of epilepsy.
Acknowledgements
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Author's contributions
The author EO confirms being the sole contributor of this work. EO conceived and designed the study, and wrote and edited the manuscript. EO has read and approved the final manuscript for publication. Data authentication is not applicable.
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Competing interests
The author declares that he has no competing interests.
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