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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2008 Volume 1 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment

  • Authors:
    • Su Jin Cho
    • Moon Jung Chae
    • Bong Kyung Shin
    • Han Kyeom Kim
    • Aeree Kim

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, College of Medicine, Korea University, Seoul 152-703, Korea
  • Pages: 83-88
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/mmr.1.1.83
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Abstract

Several peptides, such as epidermal growth factor (EGF), heregulin (HRG) and transforming growth factor alpha (TGFα), are ligands for EGFR family. Heregulin beta 1 (HRG-β1) binds to ErbB-3 and -4 and plays important roles in the proliferation and tumorigenesis of breast cancer cells. We investigated proteins through which HRG treatment affects matrix metalloproteinase (MMP)-9 activity. Breast cancer cell lines, including SK-Br3, MCF-7 and MDA-MB-231, were treated with HRG-β1. After 24 h, the activity and expression levels of MMP-9 were increased, but MMP-2 activity was not changed. The increasing rates of MMP-9 activity and expression were most prominent in the SK-Br3 cell line. Upon treatment of SK-Br3 cells with HRG-β1, phosphorylation of Akt was increased showing a peak at 30 min after treatment, and the level decreased after 6 h. The expression levels of Akt were not changed upon HRG-β1 treatment. Phosphorylation of extracellular signal-regulated kinase 1/2 (ERK-1/2), downstream molecules of Akt, was also increased by HRG-β1 treatment. Pretreatment of LY294002, PI3K inhibitor, or PD98059, MAPK inhibitor, partially blocked the heregulin-induced MMP-9 activity. Furthermore, MMP-9 was found to be secreted in human breast cancer tissues. The present results suggest that Akt and MAPK mediate HRG-β1 signaling to MMP-9.

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Copy and paste a formatted citation
Spandidos Publications style
Cho SJ, Chae MJ, Shin BK, Kim HK and Kim A: Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment. Mol Med Rep 1: 83-88, 2008.
APA
Cho, S.J., Chae, M.J., Shin, B.K., Kim, H.K., & Kim, A. (2008). Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment. Molecular Medicine Reports, 1, 83-88. https://doi.org/10.3892/mmr.1.1.83
MLA
Cho, S. J., Chae, M. J., Shin, B. K., Kim, H. K., Kim, A."Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment". Molecular Medicine Reports 1.1 (2008): 83-88.
Chicago
Cho, S. J., Chae, M. J., Shin, B. K., Kim, H. K., Kim, A."Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment". Molecular Medicine Reports 1, no. 1 (2008): 83-88. https://doi.org/10.3892/mmr.1.1.83
Copy and paste a formatted citation
x
Spandidos Publications style
Cho SJ, Chae MJ, Shin BK, Kim HK and Kim A: Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment. Mol Med Rep 1: 83-88, 2008.
APA
Cho, S.J., Chae, M.J., Shin, B.K., Kim, H.K., & Kim, A. (2008). Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment. Molecular Medicine Reports, 1, 83-88. https://doi.org/10.3892/mmr.1.1.83
MLA
Cho, S. J., Chae, M. J., Shin, B. K., Kim, H. K., Kim, A."Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment". Molecular Medicine Reports 1.1 (2008): 83-88.
Chicago
Cho, S. J., Chae, M. J., Shin, B. K., Kim, H. K., Kim, A."Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment". Molecular Medicine Reports 1, no. 1 (2008): 83-88. https://doi.org/10.3892/mmr.1.1.83
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