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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2008 Volume 1 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer

  • Authors:
    • Minako Fujita
    • Mitsuaki Ishida
    • Noriaki Tezuka
    • Shozo Fujino
    • Tohru Asai
    • Hidetoshi Okabe

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Shiga University of Medical Science, Shiga 520-2192, Japan
  • Pages: 225-230
    |
    Published online on: March 1, 2008
       https://doi.org/10.3892/mmr.1.2.225
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Abstract

The expression of human epidermal growth factor receptor (HER) family proteins was examined in specimens of 52 non-small cell lung cancers to evaluate their significance in tumor cell proliferation and their response to gefitinib. Epidermal growth factor receptor (EGFR; HER1) protein was expressed most frequently (43/52 cases). HER2 and HER3 were detected in 13 and 18 cases, respectively. HER4 was detected in only one case of squamous cell carcinoma. HER3 was expressed preferentially in adenocarcinomas of the papillary type. In most HER3-positive cases with or without other HER family proteins, the Ki-67 labelling index (18.2%) was significantly lower than in HER3-negative cases (30.6%) (P<0.05). Adenocarcinomas co-expressing EGFR, HER2 and HER3 frequently showed both a good response to gefitinib (6/7 cases) and a mutation of EGFR (4/6 cases). However, cases with a favourable response to gefitinib did not always express EGFR. Gefitinib appears to suppress growth signal pathways other than EGFR-tyrosine kinase activation in non-small cell lung cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Fujita M, Ishida M, Tezuka N, Fujino S, Asai T and Okabe H: HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer. Mol Med Rep 1: 225-230, 2008.
APA
Fujita, M., Ishida, M., Tezuka, N., Fujino, S., Asai, T., & Okabe, H. (2008). HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer. Molecular Medicine Reports, 1, 225-230. https://doi.org/10.3892/mmr.1.2.225
MLA
Fujita, M., Ishida, M., Tezuka, N., Fujino, S., Asai, T., Okabe, H."HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer". Molecular Medicine Reports 1.2 (2008): 225-230.
Chicago
Fujita, M., Ishida, M., Tezuka, N., Fujino, S., Asai, T., Okabe, H."HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer". Molecular Medicine Reports 1, no. 2 (2008): 225-230. https://doi.org/10.3892/mmr.1.2.225
Copy and paste a formatted citation
x
Spandidos Publications style
Fujita M, Ishida M, Tezuka N, Fujino S, Asai T and Okabe H: HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer. Mol Med Rep 1: 225-230, 2008.
APA
Fujita, M., Ishida, M., Tezuka, N., Fujino, S., Asai, T., & Okabe, H. (2008). HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer. Molecular Medicine Reports, 1, 225-230. https://doi.org/10.3892/mmr.1.2.225
MLA
Fujita, M., Ishida, M., Tezuka, N., Fujino, S., Asai, T., Okabe, H."HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer". Molecular Medicine Reports 1.2 (2008): 225-230.
Chicago
Fujita, M., Ishida, M., Tezuka, N., Fujino, S., Asai, T., Okabe, H."HER1-4 expression status correlates with the efficacy of gefitinib treatment and tumor cell proliferative activity in non-small cell lung cancer". Molecular Medicine Reports 1, no. 2 (2008): 225-230. https://doi.org/10.3892/mmr.1.2.225
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