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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2008 Volume 1 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

No association of the polyhistidine tract polymorphism of the ZIC2 gene with neural tube defects in a South American (ECLAMC) population

  • Authors:
    • Marcelo A. Costa-Lima
    • Heloisa N.M. Meneses
    • Kenia B. El-Jaick
    • Márcia R. Amorim
    • Eduardo E. Castilla
    • Iêda M. Orioli

  • View Affiliations / Copyright

    Affiliations: Estudo Latino Americano de Malformações Congênitas (ECLAMC) at Departamento de Genética, Universidade Federal do Rio de Janeiro, Ilha do Fundão 21949-570, Argentina
  • Pages: 443-446
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/mmr.1.3.443
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Abstract

The ZIC genes comprise a family of transcriptional factors associated with neural tube defects (NTDs) in mice and with holoprosencephaly in humans. An allelic variant of ZIC2, a CAC repeat within the first exon, was reported in association with an increased risk of non-syndromic NTDs in patients with a Hispanic ethnic background. We investigated whether this 10-residue histidine tract polymorphism of the ZIC2 gene (c.718_720dupCAC) was associated with the risk of NTDs in a sample of 138 patients and their parents from the Latin American Collaborative Study of Congenital Malformations (ECLAMC) hospital network. Analysis with log-linear models of 138 family triads of mother, father and affected child did not provide evidence to support the notion that case (or maternal) 10H/10H or −/10H genotypes were associated with NTDs in this South American population sample, where the 10H variant occurred in 5% of newborns affected with NTDs. We also described the first example of the homozygous state of the 10H allele in a patient with cephalocele, holoprosencephaly and microphthalmia, but did not ascertain whether this polymorphism is associated with the increased risk of a specific subgroup of NTDs, as a normal father of a patient with anencephaly presented the same genotype.

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Copy and paste a formatted citation
Spandidos Publications style
Costa-Lima MA, Meneses HN, El-Jaick KB, Amorim MR, Castilla EE and Orioli IM: No association of the polyhistidine tract polymorphism of the ZIC2 gene with neural tube defects in a South American (ECLAMC) population. Mol Med Rep 1: 443-446, 2008.
APA
Costa-Lima, M.A., Meneses, H.N., El-Jaick, K.B., Amorim, M.R., Castilla, E.E., & Orioli, I.M. (2008). No association of the polyhistidine tract polymorphism of the ZIC2 gene with neural tube defects in a South American (ECLAMC) population. Molecular Medicine Reports, 1, 443-446. https://doi.org/10.3892/mmr.1.3.443
MLA
Costa-Lima, M. A., Meneses, H. N., El-Jaick, K. B., Amorim, M. R., Castilla, E. E., Orioli, I. M."No association of the polyhistidine tract polymorphism of the ZIC2 gene with neural tube defects in a South American (ECLAMC) population". Molecular Medicine Reports 1.3 (2008): 443-446.
Chicago
Costa-Lima, M. A., Meneses, H. N., El-Jaick, K. B., Amorim, M. R., Castilla, E. E., Orioli, I. M."No association of the polyhistidine tract polymorphism of the ZIC2 gene with neural tube defects in a South American (ECLAMC) population". Molecular Medicine Reports 1, no. 3 (2008): 443-446. https://doi.org/10.3892/mmr.1.3.443
Copy and paste a formatted citation
x
Spandidos Publications style
Costa-Lima MA, Meneses HN, El-Jaick KB, Amorim MR, Castilla EE and Orioli IM: No association of the polyhistidine tract polymorphism of the ZIC2 gene with neural tube defects in a South American (ECLAMC) population. Mol Med Rep 1: 443-446, 2008.
APA
Costa-Lima, M.A., Meneses, H.N., El-Jaick, K.B., Amorim, M.R., Castilla, E.E., & Orioli, I.M. (2008). No association of the polyhistidine tract polymorphism of the ZIC2 gene with neural tube defects in a South American (ECLAMC) population. Molecular Medicine Reports, 1, 443-446. https://doi.org/10.3892/mmr.1.3.443
MLA
Costa-Lima, M. A., Meneses, H. N., El-Jaick, K. B., Amorim, M. R., Castilla, E. E., Orioli, I. M."No association of the polyhistidine tract polymorphism of the ZIC2 gene with neural tube defects in a South American (ECLAMC) population". Molecular Medicine Reports 1.3 (2008): 443-446.
Chicago
Costa-Lima, M. A., Meneses, H. N., El-Jaick, K. B., Amorim, M. R., Castilla, E. E., Orioli, I. M."No association of the polyhistidine tract polymorphism of the ZIC2 gene with neural tube defects in a South American (ECLAMC) population". Molecular Medicine Reports 1, no. 3 (2008): 443-446. https://doi.org/10.3892/mmr.1.3.443
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