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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2008 Volume 1 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Vitamin D3 inhibits expression of pemphigus vulgaris antigen desmoglein 3: Implication of a partial mechanism in the pharmacological effect of vitamin D3 on skin diseases

  • Authors:
    • Chiaki Yamamoto
    • Katsuto Tamai
    • Hajime Nakano
    • Yasushi Matsuzaki
    • Takahide Kaneko
    • Daisuke Sawamura

  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Aomori, Japan. derma@cc.hirosaki-u.ac.jp
  • Pages: 581-583
    |
    Published online on: July 1, 2008
       https://doi.org/10.3892/mmr.1.4.581
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Abstract

Desmoglein-3 (DSG3) is a critical molecule for adhesion between keratinocytes. Its expression can affect interactions between keratinocytes as well as keratinocyte morphology. Vitamin D3 (VD3) has been known for its role in mineral homeostasis, but has now been shown to be involved in cell differentiation, cell proliferation, immune responses and inflammation as well. Topical application of VD3 is used for the treatment of various skin diseases in present clinical practice. This study examined the effect of VD3 on DSG3 gene expression in keratinocytes. Incubation of the cultured keratinocytes with VD3 resulted in a significant decrease in Dsg3 mRNA expression. Cycloheximide treatment did not alter the inhibition rate of Dsg3 gene expression by VD3. We additionally measured the effect of VD3 on the promoter activity of the DSG3 gene. VD3 failed to inhibit promoter activities. These results suggest that down-regulation of Dsg3 expression by VD3 is independent of active protein synthesis, and may also result from keratinocyte regulatory mechanisms operating at the post-transcriptional level. Thus, the pharmacological effect of VD3 was partially mediated by the modulation of DSG3 expression through a simple pathway, without either new transcription or protein synthesis being necessary.

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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto C, Tamai K, Nakano H, Matsuzaki Y, Kaneko T and Sawamura D: Vitamin D3 inhibits expression of pemphigus vulgaris antigen desmoglein 3: Implication of a partial mechanism in the pharmacological effect of vitamin D3 on skin diseases. Mol Med Rep 1: 581-583, 2008.
APA
Yamamoto, C., Tamai, K., Nakano, H., Matsuzaki, Y., Kaneko, T., & Sawamura, D. (2008). Vitamin D3 inhibits expression of pemphigus vulgaris antigen desmoglein 3: Implication of a partial mechanism in the pharmacological effect of vitamin D3 on skin diseases. Molecular Medicine Reports, 1, 581-583. https://doi.org/10.3892/mmr.1.4.581
MLA
Yamamoto, C., Tamai, K., Nakano, H., Matsuzaki, Y., Kaneko, T., Sawamura, D."Vitamin D3 inhibits expression of pemphigus vulgaris antigen desmoglein 3: Implication of a partial mechanism in the pharmacological effect of vitamin D3 on skin diseases". Molecular Medicine Reports 1.4 (2008): 581-583.
Chicago
Yamamoto, C., Tamai, K., Nakano, H., Matsuzaki, Y., Kaneko, T., Sawamura, D."Vitamin D3 inhibits expression of pemphigus vulgaris antigen desmoglein 3: Implication of a partial mechanism in the pharmacological effect of vitamin D3 on skin diseases". Molecular Medicine Reports 1, no. 4 (2008): 581-583. https://doi.org/10.3892/mmr.1.4.581
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto C, Tamai K, Nakano H, Matsuzaki Y, Kaneko T and Sawamura D: Vitamin D3 inhibits expression of pemphigus vulgaris antigen desmoglein 3: Implication of a partial mechanism in the pharmacological effect of vitamin D3 on skin diseases. Mol Med Rep 1: 581-583, 2008.
APA
Yamamoto, C., Tamai, K., Nakano, H., Matsuzaki, Y., Kaneko, T., & Sawamura, D. (2008). Vitamin D3 inhibits expression of pemphigus vulgaris antigen desmoglein 3: Implication of a partial mechanism in the pharmacological effect of vitamin D3 on skin diseases. Molecular Medicine Reports, 1, 581-583. https://doi.org/10.3892/mmr.1.4.581
MLA
Yamamoto, C., Tamai, K., Nakano, H., Matsuzaki, Y., Kaneko, T., Sawamura, D."Vitamin D3 inhibits expression of pemphigus vulgaris antigen desmoglein 3: Implication of a partial mechanism in the pharmacological effect of vitamin D3 on skin diseases". Molecular Medicine Reports 1.4 (2008): 581-583.
Chicago
Yamamoto, C., Tamai, K., Nakano, H., Matsuzaki, Y., Kaneko, T., Sawamura, D."Vitamin D3 inhibits expression of pemphigus vulgaris antigen desmoglein 3: Implication of a partial mechanism in the pharmacological effect of vitamin D3 on skin diseases". Molecular Medicine Reports 1, no. 4 (2008): 581-583. https://doi.org/10.3892/mmr.1.4.581
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