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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2011 Volume 4 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells

  • Authors:
    • Yi Zhang
    • Xiaoman Xu
    • Ping He

  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, the Shengjing Hospital of China Medical University, Liaoning 110004, P.R. China, Department of Respiratory Medicine, The Shengjing Hospital of China Medical University, Liaoning 110004, P.R. China
  • Pages: 25-29
    |
    Published online on: October 11, 2010
       https://doi.org/10.3892/mmr.2010.379
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Abstract

Plant materials are a great source of cancer chemotherapeutic agents. Tubeimoside-1 (TBMS1) is a triterpenoid saponin extracted from the tubers of Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae), a widely prescribed traditional Chinese medicinal plant that is used for its antiviral and anti-inflammatory properties. The present study was conducted to investigate the effects of TBMS1 on the growth and apoptosis of human lung cancer A549 cells. TBMS1 inhibited the proliferation of the cells in a dose- and time-dependent manner. Apoptosis was confirmed by flow cytometry, fluorescence microscopy and transmission electron microscopy. TBMS1 treatment induced apoptosis by decreasing the expression of Bcl-2 and increasing the expression of Bax in the A549 cells. Inhibition of COX-2 was also observed after treating the cells with TBMS1. TBMS1 may prove to be a useful approach for the chemotherapy of lung cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Xu X and He P: Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells. Mol Med Rep 4: 25-29, 2011.
APA
Zhang, Y., Xu, X., & He, P. (2011). Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells. Molecular Medicine Reports, 4, 25-29. https://doi.org/10.3892/mmr.2010.379
MLA
Zhang, Y., Xu, X., He, P."Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells". Molecular Medicine Reports 4.1 (2011): 25-29.
Chicago
Zhang, Y., Xu, X., He, P."Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells". Molecular Medicine Reports 4, no. 1 (2011): 25-29. https://doi.org/10.3892/mmr.2010.379
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Xu X and He P: Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells. Mol Med Rep 4: 25-29, 2011.
APA
Zhang, Y., Xu, X., & He, P. (2011). Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells. Molecular Medicine Reports, 4, 25-29. https://doi.org/10.3892/mmr.2010.379
MLA
Zhang, Y., Xu, X., He, P."Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells". Molecular Medicine Reports 4.1 (2011): 25-29.
Chicago
Zhang, Y., Xu, X., He, P."Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells". Molecular Medicine Reports 4, no. 1 (2011): 25-29. https://doi.org/10.3892/mmr.2010.379
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