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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2011 Volume 4 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells

  • Authors:
    • Sha Peng
    • Junlin Zhang
    • Jiahuan Chen
    • Huayan Wang

  • View Affiliations / Copyright

    Affiliations: Shaanxi Key Laboratory of Molecular Biology for Agriculture, Shaanxi Stem Cell Engineering and Technology Research Center, College of Veterinary Medicine, Northwest A__AMB__F University, Shaanxi 712100, P.R. China
  • Pages: 99-104
    |
    Published online on: October 19, 2010
       https://doi.org/10.3892/mmr.2010.383
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Abstract

Placental choriocarcinoma is a highly malignant tumor of the female reproductive organs. Even with chemotherapy, placental choriocarcinoma has a 20% mortality rate due to its indistinct pathogenesis and the absence of efficient therapeutic methods for this cancer. Wnt proteins and Wnt signaling are involved in a variety of developmental and cellular processes, and aberrant activation of Wnt signaling is linked to carcinogenesis in many types of tissue. In the present study, using immunostaining and reverse transcription PCR, we found that Wnt5a was prominently expressed in human primary cytotrophoblast cells, but absent in the human choriocarcinoma cell line JAR. This implies that there is a previously unknown correlation between Wnt5a and placental choriocarcinoma. Furthermore, we found that the addition of exogenous recombinant Wnt5a protein to the JAR cells repressed their proliferation and induced apoptosis, indicating that Wnt5a has a tumor suppressive effect in placental choriocarcinoma. In conclusion, the results of the present study suggest that there is a correlation between Wnt5a and human placental choriocarcinoma; therefore, Wnt5a has a potential use in the treatment of this malignancy.

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Copy and paste a formatted citation
Spandidos Publications style
Peng S, Zhang J, Chen J and Wang H: Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells. Mol Med Rep 4: 99-104, 2011.
APA
Peng, S., Zhang, J., Chen, J., & Wang, H. (2011). Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells. Molecular Medicine Reports, 4, 99-104. https://doi.org/10.3892/mmr.2010.383
MLA
Peng, S., Zhang, J., Chen, J., Wang, H."Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells". Molecular Medicine Reports 4.1 (2011): 99-104.
Chicago
Peng, S., Zhang, J., Chen, J., Wang, H."Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells". Molecular Medicine Reports 4, no. 1 (2011): 99-104. https://doi.org/10.3892/mmr.2010.383
Copy and paste a formatted citation
x
Spandidos Publications style
Peng S, Zhang J, Chen J and Wang H: Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells. Mol Med Rep 4: 99-104, 2011.
APA
Peng, S., Zhang, J., Chen, J., & Wang, H. (2011). Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells. Molecular Medicine Reports, 4, 99-104. https://doi.org/10.3892/mmr.2010.383
MLA
Peng, S., Zhang, J., Chen, J., Wang, H."Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells". Molecular Medicine Reports 4.1 (2011): 99-104.
Chicago
Peng, S., Zhang, J., Chen, J., Wang, H."Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells". Molecular Medicine Reports 4, no. 1 (2011): 99-104. https://doi.org/10.3892/mmr.2010.383
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