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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2011 Volume 4 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration

  • Authors:
    • Qiang Yu
    • Long Chen
    • Yong You
    • Can Zou
    • Youshun  Zhang
    • Qihuan Liu
    • Fanjun Cheng

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Dongfeng Hospital, Yunyang Medical College, Shiyan 442008, P.R. China, Institute of Hematology, Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R. China, Experimental Medical Center, Dongfeng Hospital, Yunyang Medical College, Shiyan 442008, P.R. China, Experimental Medical Center, Dongfeng Hospital, Yunyang Medical College, Shiyan 442008, P.R. China, Department of Hematology, Dongfeng Hospital, Yunyang Medical College, Shiyan 442008, P.R. China
  • Pages: 31-36
    |
    Published online on: October 21, 2010
       https://doi.org/10.3892/mmr.2010.387
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Abstract

Mesenchymal stem cells (MSCs) are promising clinical tools, but the molecular mechanisms that regulate the mobilization and homing of MSCs and cause invasion through extracellular matrix (ECM) barriers are unknown. Matrix metalloproteinase (MMP) degrades the ECM and promotes cell migration. In this study, we investigated MMP expression and cell migration after treatment with erythropoietin (EPO) and granulocyte colony-stimulating factor (G-CSF). Specifically, we studied whether EPO combined with G-CSF enhanced MMP expression and increased the in vitro motility of MSCs. Real-time PCR was used to detect the mRNA of MMPs and tissue inhibitors of metalloproteinase. Cell migration was evaluated by transwell and wound healing assays. Western blotting was used to detect changes in ERK1/2 protein levels. The results showed that EPO combined with G-CSF enhanced MMP-2 expression in MSCs, promoted MSC motility and activated the ERK1/2 signaling pathway. Thus, a combination treatment of EPO with G-CSF promoted cell migration by stimulating MMP-2 expression in MSCs and this appeared to be related to the ERK1/2 signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Yu Q, Chen L, You Y, Zou C, Zhang Y, Liu Q and Cheng F: Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration. Mol Med Rep 4: 31-36, 2011.
APA
Yu, Q., Chen, L., You, Y., Zou, C., Zhang, Y., Liu, Q., & Cheng, F. (2011). Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration. Molecular Medicine Reports, 4, 31-36. https://doi.org/10.3892/mmr.2010.387
MLA
Yu, Q., Chen, L., You, Y., Zou, C., Zhang, Y., Liu, Q., Cheng, F."Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration". Molecular Medicine Reports 4.1 (2011): 31-36.
Chicago
Yu, Q., Chen, L., You, Y., Zou, C., Zhang, Y., Liu, Q., Cheng, F."Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration". Molecular Medicine Reports 4, no. 1 (2011): 31-36. https://doi.org/10.3892/mmr.2010.387
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Q, Chen L, You Y, Zou C, Zhang Y, Liu Q and Cheng F: Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration. Mol Med Rep 4: 31-36, 2011.
APA
Yu, Q., Chen, L., You, Y., Zou, C., Zhang, Y., Liu, Q., & Cheng, F. (2011). Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration. Molecular Medicine Reports, 4, 31-36. https://doi.org/10.3892/mmr.2010.387
MLA
Yu, Q., Chen, L., You, Y., Zou, C., Zhang, Y., Liu, Q., Cheng, F."Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration". Molecular Medicine Reports 4.1 (2011): 31-36.
Chicago
Yu, Q., Chen, L., You, Y., Zou, C., Zhang, Y., Liu, Q., Cheng, F."Erythropoietin combined with granulocyte colony‑stimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration". Molecular Medicine Reports 4, no. 1 (2011): 31-36. https://doi.org/10.3892/mmr.2010.387
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