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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2011 Volume 4 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2011 Volume 4 Issue 1

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Article

Effect of hyperthermia on the apoptosis and proliferation of CaSki cells

  • Authors:
    • Jumei Zhou
    • Xiaowen Wang
    • Lehui Du
    • Linyun Zhao
    • Fenglin Lei
    • Weiwei OuYang
    • Yingying Zhang
    • Yuping Liao
    • Jintian Tang

  • View Affiliations / Copyright

    Affiliations: Oncology Hospital of Hunan Province, Hunan, P.R. China, Institute of Medical Physics and Engineering, Department of Engineering Physics, Tsinghua University, Beijing, P.R. China, Department of Oncology, Xiangya Hospital of Centre South University, Changsha, Hunan, P.R. China
  • Pages: 187-191
    |
    Published online on: November 30, 2010
       https://doi.org/10.3892/mmr.2010.401
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Abstract

Hyperthermia is a promising treatment for human cervical cancer. However, little is known about whether and under what conditions heat treatment exerts tumor inhibition effects on cervical cancer, and the molecular mechanisms behind these cellular responses have yet to be elucidated. We employed the human cervical cancer cell line CaSki as a cellular model and examined the effect of cell apoptosis and proliferation under gradient thermal conditions (43, 45 and 47˚C for 40 min). Heat treatment was found to induce CaSki cell apoptosis and necrosis. Cell cycle analysis showed that cells were arrested in S phase upon the application of hyperthermia, and MTT analysis revealed that cell viability was also reduced. Of the thermal conditions, 45˚C exhibited the best induction of apoptosis, while 47˚C induced direct fierce necrosis. This was further demonstrated by examining the expression level of several key apoptosis-related genes: caspase-3, Smac and Survivin. During apoptosis, caspase-3 and Smac levels were up-regulated, whereas anti-apoptotic Survivin was down-regulated, enhancing programmed cell death. Our results reveal that heating at ≥45˚C induced cell apoptosis and necrosis, and inhibited cell proliferation at both the cellular and molecular levels. These findings support the use of hyperthermia in a clinical setting for the treatment of human cervical cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Wang X, Du L, Zhao L, Lei F, OuYang W, Zhang Y, Liao Y and Tang J: Effect of hyperthermia on the apoptosis and proliferation of CaSki cells. Mol Med Rep 4: 187-191, 2011.
APA
Zhou, J., Wang, X., Du, L., Zhao, L., Lei, F., OuYang, W. ... Tang, J. (2011). Effect of hyperthermia on the apoptosis and proliferation of CaSki cells. Molecular Medicine Reports, 4, 187-191. https://doi.org/10.3892/mmr.2010.401
MLA
Zhou, J., Wang, X., Du, L., Zhao, L., Lei, F., OuYang, W., Zhang, Y., Liao, Y., Tang, J."Effect of hyperthermia on the apoptosis and proliferation of CaSki cells". Molecular Medicine Reports 4.1 (2011): 187-191.
Chicago
Zhou, J., Wang, X., Du, L., Zhao, L., Lei, F., OuYang, W., Zhang, Y., Liao, Y., Tang, J."Effect of hyperthermia on the apoptosis and proliferation of CaSki cells". Molecular Medicine Reports 4, no. 1 (2011): 187-191. https://doi.org/10.3892/mmr.2010.401
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Wang X, Du L, Zhao L, Lei F, OuYang W, Zhang Y, Liao Y and Tang J: Effect of hyperthermia on the apoptosis and proliferation of CaSki cells. Mol Med Rep 4: 187-191, 2011.
APA
Zhou, J., Wang, X., Du, L., Zhao, L., Lei, F., OuYang, W. ... Tang, J. (2011). Effect of hyperthermia on the apoptosis and proliferation of CaSki cells. Molecular Medicine Reports, 4, 187-191. https://doi.org/10.3892/mmr.2010.401
MLA
Zhou, J., Wang, X., Du, L., Zhao, L., Lei, F., OuYang, W., Zhang, Y., Liao, Y., Tang, J."Effect of hyperthermia on the apoptosis and proliferation of CaSki cells". Molecular Medicine Reports 4.1 (2011): 187-191.
Chicago
Zhou, J., Wang, X., Du, L., Zhao, L., Lei, F., OuYang, W., Zhang, Y., Liao, Y., Tang, J."Effect of hyperthermia on the apoptosis and proliferation of CaSki cells". Molecular Medicine Reports 4, no. 1 (2011): 187-191. https://doi.org/10.3892/mmr.2010.401
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