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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2011 Volume 4 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2011 Volume 4 Issue 4

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Review

Alcohol and hepatocyte-Kupffer cell interaction (Review)

  • Authors:
    • Michael Ajakaiye
    • Asha Jacob
    • Rongqian Wu
    • Jeffrey M. Nicastro
    • Gene F. Coppa
    • Ping Wang

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, North Shore University Hospital-Long Island Jewish Medical Center, and Laboratory of Surgical Research, The Feinstein Institute for Medical Research, Manhasset, NY, USA
  • Pages: 597-602
    |
    Published online on: April 5, 2011
       https://doi.org/10.3892/mmr.2011.471
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Abstract

Alcoholic liver disease accounts for 12,000 deaths per year in the United States and is the second leading indication for liver transplantation. It covers a spectrum of disease conditions ranging from steatosis and cirrhosis to hepatic malignancies. Epidemiological data clearly show a strong correlation between alcohol consumption and liver diseases. A large body of evidence has accumulated over the years in determining the molecular mediators of alcohol-induced liver injury. In this review, we provide an overview of such mediators, which include alcohol metabolites and reactive oxygen/nitrogen species, endotoxin via bacterial translocation from the gut and TNF-α, and highlight the role of the sympathetic nervous stimuli, norepinephrine and the α2A-adrenergic receptors in contributing to the deleterious effect observed in alcohol-induced hepatic dysfunction.

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Copy and paste a formatted citation
Spandidos Publications style
Ajakaiye M, Jacob A, Wu R, Nicastro JM, Coppa GF and Wang P: Alcohol and hepatocyte-Kupffer cell interaction (Review). Mol Med Rep 4: 597-602, 2011.
APA
Ajakaiye, M., Jacob, A., Wu, R., Nicastro, J.M., Coppa, G.F., & Wang, P. (2011). Alcohol and hepatocyte-Kupffer cell interaction (Review). Molecular Medicine Reports, 4, 597-602. https://doi.org/10.3892/mmr.2011.471
MLA
Ajakaiye, M., Jacob, A., Wu, R., Nicastro, J. M., Coppa, G. F., Wang, P."Alcohol and hepatocyte-Kupffer cell interaction (Review)". Molecular Medicine Reports 4.4 (2011): 597-602.
Chicago
Ajakaiye, M., Jacob, A., Wu, R., Nicastro, J. M., Coppa, G. F., Wang, P."Alcohol and hepatocyte-Kupffer cell interaction (Review)". Molecular Medicine Reports 4, no. 4 (2011): 597-602. https://doi.org/10.3892/mmr.2011.471
Copy and paste a formatted citation
x
Spandidos Publications style
Ajakaiye M, Jacob A, Wu R, Nicastro JM, Coppa GF and Wang P: Alcohol and hepatocyte-Kupffer cell interaction (Review). Mol Med Rep 4: 597-602, 2011.
APA
Ajakaiye, M., Jacob, A., Wu, R., Nicastro, J.M., Coppa, G.F., & Wang, P. (2011). Alcohol and hepatocyte-Kupffer cell interaction (Review). Molecular Medicine Reports, 4, 597-602. https://doi.org/10.3892/mmr.2011.471
MLA
Ajakaiye, M., Jacob, A., Wu, R., Nicastro, J. M., Coppa, G. F., Wang, P."Alcohol and hepatocyte-Kupffer cell interaction (Review)". Molecular Medicine Reports 4.4 (2011): 597-602.
Chicago
Ajakaiye, M., Jacob, A., Wu, R., Nicastro, J. M., Coppa, G. F., Wang, P."Alcohol and hepatocyte-Kupffer cell interaction (Review)". Molecular Medicine Reports 4, no. 4 (2011): 597-602. https://doi.org/10.3892/mmr.2011.471
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