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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2011 Volume 4 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder

  • Authors:
    • Fei-Fei Luo
    • Fang Han
    • Yu-Xiu Shi
  • View Affiliations / Copyright

    Affiliations: Institute of Pathology and Pathophysiology, and Department of Histology and Embryology, Basic Medical Sciences College, China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 843-847
    |
    Published online on: June 24, 2011
       https://doi.org/10.3892/mmr.2011.516
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Abstract

Post-traumatic stress disorder (PTSD) is characterized mainly by symptoms of re-experiencing, avoidance and hyperarousal as a consequence of catastrophic and traumatic events that are distinguished from ordinary stressful life events. Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The dorsal raphe nucleus (DR)-serotonin (5-HT) system is markedly affected by swim stress and has been implicated in affective disorders. The 5-HT1A receptor (5-HT1AR) is critically involved in regulating mood and anxiety levels. In this study, we investigated changes in the expression of 5-HT1AR in the DR of rats after SPS that may reveal part of the pathogenesis of PTSD. 5-HT1AR expression in the DR was examined using immunohistochemistry, Western blotting and reverse transcription polymerase chain reaction. The expression of 5-HT1AR in the DR after SPS exposure was increased when compared to that in the control group (P<0.05). These findings indicate an increase in 5-HT1AR in the DR of SPS rats, which may play important roles in the pathogenesis of PTSD rats.

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Copy and paste a formatted citation
Spandidos Publications style
Luo F, Han F and Shi Y: Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder. Mol Med Rep 4: 843-847, 2011.
APA
Luo, F., Han, F., & Shi, Y. (2011). Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder. Molecular Medicine Reports, 4, 843-847. https://doi.org/10.3892/mmr.2011.516
MLA
Luo, F., Han, F., Shi, Y."Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder". Molecular Medicine Reports 4.5 (2011): 843-847.
Chicago
Luo, F., Han, F., Shi, Y."Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder". Molecular Medicine Reports 4, no. 5 (2011): 843-847. https://doi.org/10.3892/mmr.2011.516
Copy and paste a formatted citation
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Spandidos Publications style
Luo F, Han F and Shi Y: Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder. Mol Med Rep 4: 843-847, 2011.
APA
Luo, F., Han, F., & Shi, Y. (2011). Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder. Molecular Medicine Reports, 4, 843-847. https://doi.org/10.3892/mmr.2011.516
MLA
Luo, F., Han, F., Shi, Y."Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder". Molecular Medicine Reports 4.5 (2011): 843-847.
Chicago
Luo, F., Han, F., Shi, Y."Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder". Molecular Medicine Reports 4, no. 5 (2011): 843-847. https://doi.org/10.3892/mmr.2011.516
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