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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2011 Volume 4 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in chondrocytes

  • Authors:
    • Guangwen Wu
    • Thomas Sferra
    • Xuzheng Chen
    • Youqin Chen
    • Mingxia Wu
    • Huifeng Xu
    • Jun Peng
    • Xianxiang Liu

  • View Affiliations / Copyright

    Affiliations: Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Shangjie Minhou, Fuzhou 350108, P.R. China, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, P.R. China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Shangjie Minhou, Fuzhou 350108, P.R. China
  • Pages: 1001-1006
    |
    Published online on: June 30, 2011
       https://doi.org/10.3892/mmr.2011.522
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Abstract

Millimeter wave (MW) is an electromagnetic wave with a wavelength between 1 and 10 mm and a frequency of 30-300 GHz that causes multiple biological effects, both locally and globally. MW has been widely used in clinical medicine. Although our previous work demonstrated that MW is capable of inhibiting sodium nitroprussiate (SNP)-induced apoptosis in chondrocytes, the precise mechanism of the anti-apoptotic activity remains to be elucidated. The purpose of this study was to investigate the effects of MW in SNP-induced apoptotic chondrocytes. Sprague Dawley rat chondrocytes were isolated and cultured, and the cells were counted. Cell viability was evaluated using MTT assay. Cells were then treated with SNP and MW, and flow cytometry was used to detect apoptosis. Our results showed that MW treatment inhibited a SNP-induced mitochondrion-dependent pathway of apoptosis. MW treatment inhibited the loss of plasma membrane asymmetry (externalization of phosphatidylserine), collapse of mitochondrial membrane potential, and activation of caspase-9 and caspase-3. Taken together, the results indicate that MW inhibits the mitochondrion-dependent pathway of apoptosis in chondrocytes and this may, in part, explain its clinical effect in the treatment of osteoarthritis.

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Copy and paste a formatted citation
Spandidos Publications style
Wu G, Sferra T, Chen X, Chen Y, Wu M, Xu H, Peng J and Liu X: Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in chondrocytes. Mol Med Rep 4: 1001-1006, 2011.
APA
Wu, G., Sferra, T., Chen, X., Chen, Y., Wu, M., Xu, H. ... Liu, X. (2011). Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in chondrocytes. Molecular Medicine Reports, 4, 1001-1006. https://doi.org/10.3892/mmr.2011.522
MLA
Wu, G., Sferra, T., Chen, X., Chen, Y., Wu, M., Xu, H., Peng, J., Liu, X."Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in chondrocytes". Molecular Medicine Reports 4.5 (2011): 1001-1006.
Chicago
Wu, G., Sferra, T., Chen, X., Chen, Y., Wu, M., Xu, H., Peng, J., Liu, X."Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in chondrocytes". Molecular Medicine Reports 4, no. 5 (2011): 1001-1006. https://doi.org/10.3892/mmr.2011.522
Copy and paste a formatted citation
x
Spandidos Publications style
Wu G, Sferra T, Chen X, Chen Y, Wu M, Xu H, Peng J and Liu X: Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in chondrocytes. Mol Med Rep 4: 1001-1006, 2011.
APA
Wu, G., Sferra, T., Chen, X., Chen, Y., Wu, M., Xu, H. ... Liu, X. (2011). Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in chondrocytes. Molecular Medicine Reports, 4, 1001-1006. https://doi.org/10.3892/mmr.2011.522
MLA
Wu, G., Sferra, T., Chen, X., Chen, Y., Wu, M., Xu, H., Peng, J., Liu, X."Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in chondrocytes". Molecular Medicine Reports 4.5 (2011): 1001-1006.
Chicago
Wu, G., Sferra, T., Chen, X., Chen, Y., Wu, M., Xu, H., Peng, J., Liu, X."Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in chondrocytes". Molecular Medicine Reports 4, no. 5 (2011): 1001-1006. https://doi.org/10.3892/mmr.2011.522
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