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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells

  • Authors:
    • Jieming Xie
    • Wenzhong Que
    • Huili Liu
    • Mei Liu
    • Aiqin Yang
    • Minghuang Chen

  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Fujian Medical University, Taijiang, Fuzhou, Fujian 350005, P.R. China, Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fujian, P.R. China, Zhangzhou Health Vocational College, Zhangzhou, P.R. China, Department of Hematology, The Second Hospital of Yulin, Shanxi, P.R. China, The State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, P.R. China
  • Pages: 196-201
    |
    Published online on: September 30, 2011
       https://doi.org/10.3892/mmr.2011.605
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Abstract

We extracted cucurmosin (CUS) from the sarcocarp of Cucrubita moschata (pumpkin). Recently, a number of studies have indicated that CUS has cytotoxic properties and induces apoptosis in a number of human tumor cells. However, the detailed mechanisms are largely unknown. The aim of this study was to confirm CUS's anticancer activity on human hepatoma HepG2 cells in vitro and in vivo, and to elucidate the mechanism of its activity. MTT was used to detect the cytotoxic effects of CUS. Flow cytometry was used to analyze cell apoptosis and the cell cycle. Transmission electron microscopy was used to observe the morphology of apoptotic cells. Western blot analysis was performed to measure the protein expression of bax, bcl-2 and procaspase-3. The established orthotopic transplantation models of human hepatoma in NOD/SCID mice were tested for anticancer activities in vivo. The results showed that CUS inhibited the proliferation of HepG2 cells in vitro and in vivo. CUS induced apoptosis and arrested the cell cycle. In addition, CUS increased the protein expression of bax, but decreased the bcl-2 and procaspase-3 expression in HepG2 cells. Our data indicate that CUS has potential anticancer activity for human hepatoma, which can be attributed in part to its inhibition of proliferation and apoptosis, induced by decreasing the bcl-2:bax ratio and caspase-3 activation.

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Copy and paste a formatted citation
Spandidos Publications style
Xie J, Que W, Liu H, Liu M, Yang A and Chen M: Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells. Mol Med Rep 5: 196-201, 2012.
APA
Xie, J., Que, W., Liu, H., Liu, M., Yang, A., & Chen, M. (2012). Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells. Molecular Medicine Reports, 5, 196-201. https://doi.org/10.3892/mmr.2011.605
MLA
Xie, J., Que, W., Liu, H., Liu, M., Yang, A., Chen, M."Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells". Molecular Medicine Reports 5.1 (2012): 196-201.
Chicago
Xie, J., Que, W., Liu, H., Liu, M., Yang, A., Chen, M."Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells". Molecular Medicine Reports 5, no. 1 (2012): 196-201. https://doi.org/10.3892/mmr.2011.605
Copy and paste a formatted citation
x
Spandidos Publications style
Xie J, Que W, Liu H, Liu M, Yang A and Chen M: Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells. Mol Med Rep 5: 196-201, 2012.
APA
Xie, J., Que, W., Liu, H., Liu, M., Yang, A., & Chen, M. (2012). Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells. Molecular Medicine Reports, 5, 196-201. https://doi.org/10.3892/mmr.2011.605
MLA
Xie, J., Que, W., Liu, H., Liu, M., Yang, A., Chen, M."Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells". Molecular Medicine Reports 5.1 (2012): 196-201.
Chicago
Xie, J., Que, W., Liu, H., Liu, M., Yang, A., Chen, M."Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells". Molecular Medicine Reports 5, no. 1 (2012): 196-201. https://doi.org/10.3892/mmr.2011.605
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