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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors

  • Authors:
    • Wen-Hui Weng
    • Chun-Nan Yeh
    • Yung-Feng Cheng
    • Govinda Lenka
    • Yi-Wei Liaw

  • View Affiliations / Copyright

    Affiliations: Department of Chemical Engineering and Biotechnology, Graduate Institute of Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan, R.O.C., Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, R.O.C., College of Engineering, Energy and Optoelectronic Materials Program, National Taipei University of Technology, Taipei, Taiwan, R.O.C.
  • Pages: 17-21
    |
    Published online on: October 3, 2011
       https://doi.org/10.3892/mmr.2011.609
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Abstract

Membrane-cytoskeleton linker organizer ezrin is a member of the ERM (ezrin-radixin-moesin) protein family. It has been suggested as an important element in the oncogenic process, particularly in conferring a metastatic ability on tumor cells. We hypothesized that the KIT oncogenic form is one of the proteins that modulates expression of the ezrin protein via phosphorylated ezrin at different residues; furthermore, it may interact with the protein merlin, and promoting tumor development via the PI3K or MAPK pathway. In the present study, we observed that differential expression of ezrin was a common feature in gastrointestinal stromal tumors (GISTs). We further demonstrated that cases exhibiting expression of phosphorylated Thr567 in the ezrin protein were associated with immunoactivities of KIT and merlin expression (p=0.039 and 0.013, respectively). In conclusion, GISTs harbor activation of KIT protein may induce phosphorylation of the downstream protein ezrin at certain residues, thereby triggering subsequent signal transduction cascades and driving downstream pathways of tumor progression. However, a larger series of tumor samples should be analyzed in future studies, as well as the identification of phosphorylated sites to determine the role of ezrin in tumor progression thus shedding light on clinical outcomes.

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Copy and paste a formatted citation
Spandidos Publications style
Weng W, Yeh C, Cheng Y, Lenka G and Liaw Y: Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors. Mol Med Rep 5: 17-21, 2012.
APA
Weng, W., Yeh, C., Cheng, Y., Lenka, G., & Liaw, Y. (2012). Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors. Molecular Medicine Reports, 5, 17-21. https://doi.org/10.3892/mmr.2011.609
MLA
Weng, W., Yeh, C., Cheng, Y., Lenka, G., Liaw, Y."Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors". Molecular Medicine Reports 5.1 (2012): 17-21.
Chicago
Weng, W., Yeh, C., Cheng, Y., Lenka, G., Liaw, Y."Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors". Molecular Medicine Reports 5, no. 1 (2012): 17-21. https://doi.org/10.3892/mmr.2011.609
Copy and paste a formatted citation
x
Spandidos Publications style
Weng W, Yeh C, Cheng Y, Lenka G and Liaw Y: Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors. Mol Med Rep 5: 17-21, 2012.
APA
Weng, W., Yeh, C., Cheng, Y., Lenka, G., & Liaw, Y. (2012). Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors. Molecular Medicine Reports, 5, 17-21. https://doi.org/10.3892/mmr.2011.609
MLA
Weng, W., Yeh, C., Cheng, Y., Lenka, G., Liaw, Y."Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors". Molecular Medicine Reports 5.1 (2012): 17-21.
Chicago
Weng, W., Yeh, C., Cheng, Y., Lenka, G., Liaw, Y."Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors". Molecular Medicine Reports 5, no. 1 (2012): 17-21. https://doi.org/10.3892/mmr.2011.609
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