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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients

  • Authors:
    • Xin-Lin Zhang
    • Cheng-Wei Zhang
    • Pei Xu
    • Feng-Jing Liang
    • Ye-Na Che
    • Yan-Jie Xia
    • Yun-Xia Cao
    • Xiao-Ke Wu
    • Wen-Jun Wang
    • Long Yi
    • Qian Gao
    • Yong Wang

  • View Affiliations / Copyright

    Affiliations: Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, P.R. China, Department of Obstetrics and Gynecology, Anhui Medical University, Hefei 230022, P.R. China, Department of Obstetrics and Gynecology, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, P.R. China, Centre of Reproduction, Department of Obstetric and Gynaecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, P.R. China, Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, P.R. China
  • Pages: 245-249
    |
    Published online on: October 3, 2011
       https://doi.org/10.3892/mmr.2011.616
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Abstract

CYP19 encodes aromatase, a key enzyme essential for estrogen biosynthesis. Single nucleotide polymorphism (SNP) rs2470152 in CYP19 is associated with serum estradiol (E2) level and the E2/T (estradiol/testosterone) ratio. A case‑control study including 661 individuals [364 polycystic ovary syndrome (PCOS) patients and 297 controls] was conducted to assess the association of SNP rs2470152 with PCOS. The subjects were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Hormone levels were analyzed among various genotypes. The genotypic distributions of rs2470152 did not differ in PCOS patients when compared to the controls. However, differences in the E2/T ratio were detected, exhibiting a lower ratio in the heterozygous TC genotype in PCOS patients (p=0.01036) and controls (p=0.000). Testosterone levels also differed between the three genotypes of PCOS patients (p=0.00625), with a higher level in the TC genotype. Therefore, rs2470152 in CYP19 was not a major etiological factor for PCOS; however, the heterozygous TC genotype may inhibit aromatase activity, resulting in hyperandrogenism, particularly in PCOS patients.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Zhang C, Xu P, Liang F, Che Y, Xia Y, Cao Y, Wu X, Wang W, Yi L, Yi L, et al: SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients. Mol Med Rep 5: 245-249, 2012.
APA
Zhang, X., Zhang, C., Xu, P., Liang, F., Che, Y., Xia, Y. ... Wang, Y. (2012). SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients. Molecular Medicine Reports, 5, 245-249. https://doi.org/10.3892/mmr.2011.616
MLA
Zhang, X., Zhang, C., Xu, P., Liang, F., Che, Y., Xia, Y., Cao, Y., Wu, X., Wang, W., Yi, L., Gao, Q., Wang, Y."SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients". Molecular Medicine Reports 5.1 (2012): 245-249.
Chicago
Zhang, X., Zhang, C., Xu, P., Liang, F., Che, Y., Xia, Y., Cao, Y., Wu, X., Wang, W., Yi, L., Gao, Q., Wang, Y."SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients". Molecular Medicine Reports 5, no. 1 (2012): 245-249. https://doi.org/10.3892/mmr.2011.616
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Zhang C, Xu P, Liang F, Che Y, Xia Y, Cao Y, Wu X, Wang W, Yi L, Yi L, et al: SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients. Mol Med Rep 5: 245-249, 2012.
APA
Zhang, X., Zhang, C., Xu, P., Liang, F., Che, Y., Xia, Y. ... Wang, Y. (2012). SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients. Molecular Medicine Reports, 5, 245-249. https://doi.org/10.3892/mmr.2011.616
MLA
Zhang, X., Zhang, C., Xu, P., Liang, F., Che, Y., Xia, Y., Cao, Y., Wu, X., Wang, W., Yi, L., Gao, Q., Wang, Y."SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients". Molecular Medicine Reports 5.1 (2012): 245-249.
Chicago
Zhang, X., Zhang, C., Xu, P., Liang, F., Che, Y., Xia, Y., Cao, Y., Wu, X., Wang, W., Yi, L., Gao, Q., Wang, Y."SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients". Molecular Medicine Reports 5, no. 1 (2012): 245-249. https://doi.org/10.3892/mmr.2011.616
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