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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells

  • Authors:
    • Delin Yang
    • Jiansong Wang
    • Jun Li
    • Haifeng Wang
    • Huihai  He
    • Chao Zhang
    • Kai Wang
    • Hongyi Xu

  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Institute of Urology, Kunming 650101, P.R. China, The First Affiliated Hospital of Kunming Medical University, Kunming 650031, P.R. China
  • Pages: 266-269
    |
    Published online on: October 11, 2011
       https://doi.org/10.3892/mmr.2011.622
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Abstract

We investigated the effect of membrane toxin 12 (MT-12), isolated from Naja naja atra, a species of Chinese Cobra, on the proliferation and invasion of human bladder cancer EJ cells and studied its mechanisms using MTT assay, Transwell chamber invasion assay, scanning electron microscopy and flow cytometry. The results indicated that MT-12 inhibited the proliferation of bladder cancer cells in a dose‑dependent manner. The half maximal inhibitory concentration (IC50) after 72 h was 0.66 µg/ml. The invasion of cells decreased with increasing doses of MT-12 (0.125-0.5 µg/ml, P<0.001). Expression of CXCR4 decreased with the effect of MT-12 for a particular concentration range (0.125-0.5 µg/ml). To conclude, MT-12 is capable of inhibiting the proliferation and invasion of bladder cancer EJ cells. This mechanism may be associated with reduced expression of CXCR4 protein.

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Copy and paste a formatted citation
Spandidos Publications style
Yang D, Wang J, Li J, Wang H, He H, Zhang C, Wang K and Xu H: Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells. Mol Med Rep 5: 266-269, 2012.
APA
Yang, D., Wang, J., Li, J., Wang, H., He, H., Zhang, C. ... Xu, H. (2012). Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells. Molecular Medicine Reports, 5, 266-269. https://doi.org/10.3892/mmr.2011.622
MLA
Yang, D., Wang, J., Li, J., Wang, H., He, H., Zhang, C., Wang, K., Xu, H."Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells". Molecular Medicine Reports 5.1 (2012): 266-269.
Chicago
Yang, D., Wang, J., Li, J., Wang, H., He, H., Zhang, C., Wang, K., Xu, H."Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells". Molecular Medicine Reports 5, no. 1 (2012): 266-269. https://doi.org/10.3892/mmr.2011.622
Copy and paste a formatted citation
x
Spandidos Publications style
Yang D, Wang J, Li J, Wang H, He H, Zhang C, Wang K and Xu H: Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells. Mol Med Rep 5: 266-269, 2012.
APA
Yang, D., Wang, J., Li, J., Wang, H., He, H., Zhang, C. ... Xu, H. (2012). Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells. Molecular Medicine Reports, 5, 266-269. https://doi.org/10.3892/mmr.2011.622
MLA
Yang, D., Wang, J., Li, J., Wang, H., He, H., Zhang, C., Wang, K., Xu, H."Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells". Molecular Medicine Reports 5.1 (2012): 266-269.
Chicago
Yang, D., Wang, J., Li, J., Wang, H., He, H., Zhang, C., Wang, K., Xu, H."Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells". Molecular Medicine Reports 5, no. 1 (2012): 266-269. https://doi.org/10.3892/mmr.2011.622
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