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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo

  • Authors:
    • Su-Yu Chien
    • Shou-Jen Kuo
    • Yao-Li Chen
    • Dar-Ren Chen
    • Chun-Yuan Cheng
    • Chin-Cheng Su

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Changhua Christian Hospital, Changhua City, Changhua, Taiwan, R.O.C., Department of Surgery, Changhua Christian Hospital, Changhua City, Changhua, Taiwan, R.O.C., Department of Surgery, Comprehensive Breast Cancer Center, Laboratory of Integrative Medicine Cancer Research, Changhua Christian Hospital, Changhua City, Changhua 500-06, Taiwan, R.O.C.
  • Pages: 282-286
    |
    Published online on: October 14, 2011
       https://doi.org/10.3892/mmr.2011.631
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Abstract

Tanshinone IIA (Tan‑IIA) decreases the viability of human hepatocellular carcinoma (HCC) cells through the induction of apoptosis in vitro. However, there are no reports that Tan‑IIA is capable of inhibiting J5 HCC cell growth in vivo. In this study, J5 cells were implanted directly into nude SCID mice which were divided randomly into four groups to be treated with vehicle, Tan‑IIA (30 mg/­kg of body weight, Q.week days 3 and 5), 5‑FU (30 mg/­kg of body weight, Q.week day 1) or Tan‑IIA (30 mg/­kg of body weight, Q.week days 3 and 5) plus 5‑FU (30 mg/­kg of body weight, Q.week day 1). Each agent was injected intraperitoneally, with treatment starting 4 weeks after inoculation with J5 cells. Treatment with Tan‑IIA 30 mg/­kg or with 30 mg/­kg of 5‑FU resulted in a reduction in tumor size and weight compared with the control group. The protein expression of Bax and caspase-3 in the J5 xenograft tumors treated with Tan‑IIA 30 mg/­kg or with 30 mg/kg of 5‑FU was upregulated, whereas that of CD31 was downregulated compared with the control group. These findings indicate that Tan‑IIA may inhibit tumor growth in a J5 xenograft animal model by increasing Bax and caspase 3 and decreasing CD31 expression in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
Chien S, Kuo S, Chen Y, Chen D, Cheng C and Su C: Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo. Mol Med Rep 5: 282-286, 2012.
APA
Chien, S., Kuo, S., Chen, Y., Chen, D., Cheng, C., & Su, C. (2012). Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo. Molecular Medicine Reports, 5, 282-286. https://doi.org/10.3892/mmr.2011.631
MLA
Chien, S., Kuo, S., Chen, Y., Chen, D., Cheng, C., Su, C."Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo". Molecular Medicine Reports 5.1 (2012): 282-286.
Chicago
Chien, S., Kuo, S., Chen, Y., Chen, D., Cheng, C., Su, C."Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo". Molecular Medicine Reports 5, no. 1 (2012): 282-286. https://doi.org/10.3892/mmr.2011.631
Copy and paste a formatted citation
x
Spandidos Publications style
Chien S, Kuo S, Chen Y, Chen D, Cheng C and Su C: Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo. Mol Med Rep 5: 282-286, 2012.
APA
Chien, S., Kuo, S., Chen, Y., Chen, D., Cheng, C., & Su, C. (2012). Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo. Molecular Medicine Reports, 5, 282-286. https://doi.org/10.3892/mmr.2011.631
MLA
Chien, S., Kuo, S., Chen, Y., Chen, D., Cheng, C., Su, C."Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo". Molecular Medicine Reports 5.1 (2012): 282-286.
Chicago
Chien, S., Kuo, S., Chen, Y., Chen, D., Cheng, C., Su, C."Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo". Molecular Medicine Reports 5, no. 1 (2012): 282-286. https://doi.org/10.3892/mmr.2011.631
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