Mesangial IgA deposits indicate pathogenesis of anti-glomerular basement membrane disease

  • Authors:
    • Aifeng Wang
    • Yongping Wang
    • Guobao Wang
    • Zhanmei Zhou
    • Zhang Xun
    • Xiaohui Tan
  • View Affiliations

  • Published online on: February 24, 2012     https://doi.org/10.3892/mmr.2012.809
  • Pages: 1212-1214
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Anti-glomerular basement membrane (anti-GBM) disease is characterized by crescentic glomerulonephritis with immunoglobulin G (IgG) autoantibodies to the non-collagenous (NC1) domain of α3(IV) collagen presenting along the GBM. The patient clinically manifests with rapidly progressive glomerulonephritis (RPGN) with pulmonary hemorrhage (Goodpasture syndrome). In rare cases, other immunocomplexes of IgA or IgM are involved, but their specificities have not been determined. We report a rare case of a 31-year-old female who was diagnosed as having anti-GBM disease with extensive IgA deposits in the mesangium. This patient presented heavy hematuria, proteinuria with increasing creatinine, but no lung hemorrhage. Renal biopsy showed crescentic glomerulonephritis (type Ⅰ) with strong IgA (3+) as lump and branch shape. Therapies with pulse methylprednisolone, plasmapheresis and cyclophosphamide administration were less effective. This case is different from the present type Ⅰ crescentic glomerulonephritis and the specificity of IgA deposits may implicate the pathogenesis of anti-GBM disease.

Related Articles

Journal Cover

May 2012
Volume 5 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Wang, A., Wang, Y., Wang, G., Zhou, Z., Xun, Z., & Tan, X. (2012). Mesangial IgA deposits indicate pathogenesis of anti-glomerular basement membrane disease. Molecular Medicine Reports, 5, 1212-1214. https://doi.org/10.3892/mmr.2012.809
MLA
Wang, A., Wang, Y., Wang, G., Zhou, Z., Xun, Z., Tan, X."Mesangial IgA deposits indicate pathogenesis of anti-glomerular basement membrane disease". Molecular Medicine Reports 5.5 (2012): 1212-1214.
Chicago
Wang, A., Wang, Y., Wang, G., Zhou, Z., Xun, Z., Tan, X."Mesangial IgA deposits indicate pathogenesis of anti-glomerular basement membrane disease". Molecular Medicine Reports 5, no. 5 (2012): 1212-1214. https://doi.org/10.3892/mmr.2012.809