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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention

  • Authors:
    • Jin Yao
    • Wen Yang
    • Yuan Liu
    • Yan-Xi Sun
    • Qin Jiang

  • View Affiliations / Copyright

    Affiliations: The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, P.R. China
  • Pages: 1509-1513
    |
    Published online on: March 8, 2012
       https://doi.org/10.3892/mmr.2012.827
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Abstract

The elevation of transforming growth factor-β2 (TGF-β2) levels in eye tissue is considered as one of the major factors contributing to posterior capsule opacification (PCO) in patients undergoing cataract surgery, since TGF-β2 is known to stimulate the cell migration of residual human lens epithelial cells (HLECs). The present study aimed to test the potential effect of dexamethasone (DEX) on TGF-β2-induced cell migration and the possible cellular mechanisms involved in this process. Cultured HLE-B3 cells were treated with TGF-β2 (0.1 ng/ml) in the presence or absence of DEX (100 nM). HLE-B3 cell migration was determined by the Phagokinetic Track Motility Assay. Activation of mitogen-activated protein kinase (MAPK) signaling pathways was determined by Western blotting using specific phosphorylation antibodies, matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expression, and activities were analyzed by RT-PCR and gelatin zymography assay, respectively. In cultured HLE-B3 cells, DEX largely inhibited TGF-β2-induced cell migration and MMP activity, probably by inhibiting the ERK/MAPK pathway. We suggest that the use of DEX may be of help in the prevention of PCO formation and development.

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Copy and paste a formatted citation
Spandidos Publications style
Yao J, Yang W, Liu Y, Sun Y and Jiang Q: Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention. Mol Med Rep 5: 1509-1513, 2012.
APA
Yao, J., Yang, W., Liu, Y., Sun, Y., & Jiang, Q. (2012). Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention. Molecular Medicine Reports, 5, 1509-1513. https://doi.org/10.3892/mmr.2012.827
MLA
Yao, J., Yang, W., Liu, Y., Sun, Y., Jiang, Q."Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention". Molecular Medicine Reports 5.6 (2012): 1509-1513.
Chicago
Yao, J., Yang, W., Liu, Y., Sun, Y., Jiang, Q."Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention". Molecular Medicine Reports 5, no. 6 (2012): 1509-1513. https://doi.org/10.3892/mmr.2012.827
Copy and paste a formatted citation
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Spandidos Publications style
Yao J, Yang W, Liu Y, Sun Y and Jiang Q: Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention. Mol Med Rep 5: 1509-1513, 2012.
APA
Yao, J., Yang, W., Liu, Y., Sun, Y., & Jiang, Q. (2012). Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention. Molecular Medicine Reports, 5, 1509-1513. https://doi.org/10.3892/mmr.2012.827
MLA
Yao, J., Yang, W., Liu, Y., Sun, Y., Jiang, Q."Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention". Molecular Medicine Reports 5.6 (2012): 1509-1513.
Chicago
Yao, J., Yang, W., Liu, Y., Sun, Y., Jiang, Q."Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention". Molecular Medicine Reports 5, no. 6 (2012): 1509-1513. https://doi.org/10.3892/mmr.2012.827
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