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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model

  • Authors:
    • Qingjuan Shang
    • Dianliang Zhang
    • Chunbao Guo
    • Qiu Lin
    • Zhenhua Guo
    • Chun Deng

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Linyi Municipal Hospital, Linyi, Shandong, P.R. China, Department of Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, P.R. China, Laboratory of Surgery, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China
  • Pages: 1401-1408
    |
    Published online on: March 22, 2012
       https://doi.org/10.3892/mmr.2012.844
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Abstract

We report that Bim has an apoptotic function through Bax/mitochondrial apoptosis signaling in the p53-independent mode, which is somewhat additive to the effects of p53. Bim-deficient mouse embryonic fibroblast (MEF) cells were resistant to the apoptotic effects of Myc, while loss of Bim accelerated lymphoma development. Furthermore, Bim was overexpressed at the same frequency in Myc-initiated lymphomas, irrespective of p53 status, suggesting that Bim resides in a pathway separate from p53. Loss of Bim further augmented resistance to apoptosis in p53-/- MEFs. Mice with p53 knockdown exhibited exacerbated malignancies in the absence of Bim. The combined loss of these proteins promoted more severe spontaneous tumorigenesis. Thus, Myc-induced apoptotic signals through Bim and p53 must bifurcate to activate Bax, suggesting that the activation of Bim and p53 significantly contribute to apoptosis. Our results, therefore, establish that p53 and Bim are effective key initiators of apoptosis in lymphoma cells, particularly when combined.

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Copy and paste a formatted citation
Spandidos Publications style
Shang Q, Zhang D, Guo C, Lin Q, Guo Z and Deng C: Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model. Mol Med Rep 5: 1401-1408, 2012.
APA
Shang, Q., Zhang, D., Guo, C., Lin, Q., Guo, Z., & Deng, C. (2012). Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model. Molecular Medicine Reports, 5, 1401-1408. https://doi.org/10.3892/mmr.2012.844
MLA
Shang, Q., Zhang, D., Guo, C., Lin, Q., Guo, Z., Deng, C."Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model". Molecular Medicine Reports 5.6 (2012): 1401-1408.
Chicago
Shang, Q., Zhang, D., Guo, C., Lin, Q., Guo, Z., Deng, C."Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model". Molecular Medicine Reports 5, no. 6 (2012): 1401-1408. https://doi.org/10.3892/mmr.2012.844
Copy and paste a formatted citation
x
Spandidos Publications style
Shang Q, Zhang D, Guo C, Lin Q, Guo Z and Deng C: Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model. Mol Med Rep 5: 1401-1408, 2012.
APA
Shang, Q., Zhang, D., Guo, C., Lin, Q., Guo, Z., & Deng, C. (2012). Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model. Molecular Medicine Reports, 5, 1401-1408. https://doi.org/10.3892/mmr.2012.844
MLA
Shang, Q., Zhang, D., Guo, C., Lin, Q., Guo, Z., Deng, C."Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model". Molecular Medicine Reports 5.6 (2012): 1401-1408.
Chicago
Shang, Q., Zhang, D., Guo, C., Lin, Q., Guo, Z., Deng, C."Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model". Molecular Medicine Reports 5, no. 6 (2012): 1401-1408. https://doi.org/10.3892/mmr.2012.844
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