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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation

  • Authors:
    • Xuefeng Yang
    • Xuyu Zu
    • Jing Tang
    • Wei Xiong
    • Yuan  Zhang
    • Feng Liu
    • Yuyang Jiang

  • View Affiliations / Copyright

    Affiliations: Nanhuan Hospital, University of South China, Hengyang, Hunan 421001, P.R. China, Clinical Medicine Institution, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China, The Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, P.R. China
  • Pages: 1475-1480
    |
    Published online on: March 23, 2012
       https://doi.org/10.3892/mmr.2012.846
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Abstract

Zbtb7, a member of the POK protein family, is involved in tumorigenesis and cellular differentiation by acting as a crucial transcription factor, but its role in cell cycle modulation remains uncharacterized. In the present study, CDK2 and E2F4, two cell cycle regulators, are shown to be downregulated at the mRNA and protein levels by Zbtb7 in HepG2 and QGY7703 cells. Moreover, we demonstrate that the activities of CDK2 and E2F4 promoters were suppressed by the modulation of Zbtb7 levels and that Zbtb7 represses promoter activities through a mechanism involving direct binding of Zbtb7 to the promoters. Furthermore, it was identified that the site at -259 to -252 within the CDK2 promoter is responsible for Zbtb7-induced repression of the promoter activity. It was found that siRNA‑induced knockdown of Zbtb7 resulted in the suppression of cell cycle progression in HepG2 and QGY7703 cells. Collectively, these data indicate that CDK2 and E2F4 are the downstream targets of Zbtb7, and Zbtb7 may be a cell cycle modulator by regulating the expression of cell cycle-associated genes in liver cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Zu X, Tang J, Xiong W, Zhang Y, Liu F and Jiang Y: Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation. Mol Med Rep 5: 1475-1480, 2012.
APA
Yang, X., Zu, X., Tang, J., Xiong, W., Zhang, Y., Liu, F., & Jiang, Y. (2012). Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation. Molecular Medicine Reports, 5, 1475-1480. https://doi.org/10.3892/mmr.2012.846
MLA
Yang, X., Zu, X., Tang, J., Xiong, W., Zhang, Y., Liu, F., Jiang, Y."Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation". Molecular Medicine Reports 5.6 (2012): 1475-1480.
Chicago
Yang, X., Zu, X., Tang, J., Xiong, W., Zhang, Y., Liu, F., Jiang, Y."Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation". Molecular Medicine Reports 5, no. 6 (2012): 1475-1480. https://doi.org/10.3892/mmr.2012.846
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Zu X, Tang J, Xiong W, Zhang Y, Liu F and Jiang Y: Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation. Mol Med Rep 5: 1475-1480, 2012.
APA
Yang, X., Zu, X., Tang, J., Xiong, W., Zhang, Y., Liu, F., & Jiang, Y. (2012). Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation. Molecular Medicine Reports, 5, 1475-1480. https://doi.org/10.3892/mmr.2012.846
MLA
Yang, X., Zu, X., Tang, J., Xiong, W., Zhang, Y., Liu, F., Jiang, Y."Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation". Molecular Medicine Reports 5.6 (2012): 1475-1480.
Chicago
Yang, X., Zu, X., Tang, J., Xiong, W., Zhang, Y., Liu, F., Jiang, Y."Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation". Molecular Medicine Reports 5, no. 6 (2012): 1475-1480. https://doi.org/10.3892/mmr.2012.846
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