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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner

  • Authors:
    • Xianglin Dong
    • Junjie Chen
    • Yange Zhang
    • Ying Cen

  • View Affiliations / Copyright

    Affiliations: Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 1487-1490
    |
    Published online on: March 30, 2012
       https://doi.org/10.3892/mmr.2012.851
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Abstract

Wound healing is a complex process, with various intracellular molecules and cytokines involved. Chymase is a chymotrypsin-like serine protease originally found to be a mast cell protease. In this study, to further investigate the role of chymase in the process of wound healing, the effects of chymase on cell proliferation and cytokine activation in human skin fibroblasts were determined. To determine cell proliferation, MTT assay was employed. The cells were harvested and total proteins were extracted and detected by western blotting. It was found that in vitro cell treatments with chymase led to dose-dependent increases of skin fibroblast proliferation. Moreover, the treatment of cells with chymase for 6 h induced dose-dependent increases in the expression levels of transforming growth factor (TGF)-β1 and interleukin (IL)-1β, although higher doses (120 ng/ml for TGF-β1; 60 and 120 ng/ml for IL-1β) did not facilitate the detected cytokine expression. In addition, treatment for longer periods of time (12 or 24 h) did not increase TGF-β1 or IL-1β expression. The results from our study will strongly facilitate the understanding of the roles of chymase in the process of wound healing.

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Copy and paste a formatted citation
Spandidos Publications style
Dong X, Chen J, Zhang Y and Cen Y: Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner. Mol Med Rep 5: 1487-1490, 2012.
APA
Dong, X., Chen, J., Zhang, Y., & Cen, Y. (2012). Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner. Molecular Medicine Reports, 5, 1487-1490. https://doi.org/10.3892/mmr.2012.851
MLA
Dong, X., Chen, J., Zhang, Y., Cen, Y."Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner". Molecular Medicine Reports 5.6 (2012): 1487-1490.
Chicago
Dong, X., Chen, J., Zhang, Y., Cen, Y."Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner". Molecular Medicine Reports 5, no. 6 (2012): 1487-1490. https://doi.org/10.3892/mmr.2012.851
Copy and paste a formatted citation
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Spandidos Publications style
Dong X, Chen J, Zhang Y and Cen Y: Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner. Mol Med Rep 5: 1487-1490, 2012.
APA
Dong, X., Chen, J., Zhang, Y., & Cen, Y. (2012). Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner. Molecular Medicine Reports, 5, 1487-1490. https://doi.org/10.3892/mmr.2012.851
MLA
Dong, X., Chen, J., Zhang, Y., Cen, Y."Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner". Molecular Medicine Reports 5.6 (2012): 1487-1490.
Chicago
Dong, X., Chen, J., Zhang, Y., Cen, Y."Mast cell chymase promotes cell proliferation and expression of certain cytokines in a dose-dependent manner". Molecular Medicine Reports 5, no. 6 (2012): 1487-1490. https://doi.org/10.3892/mmr.2012.851
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