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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June 2012 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty

  • Authors:
    • Bingbing Ma
    • Gangzhu Liang
    • Fuxian Zhang
    • Yizhi Chen
    • Huan Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Beijing Shijitan Hospital, Ninth Clinical Hospital of Peking University, Haidian, Beijing 100038, P.R. China, Department of Pathology, Beijing Shijitan Hospital, Ninth Clinical Hospital of Peking University, Haidian, Beijing 100038, P.R. China
  • Pages: 1497-1502
    |
    Published online on: April 2, 2012
       https://doi.org/10.3892/mmr.2012.853
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Abstract

Peripheral artery disease (PAD) may lead to a poor quality of life. Although percutaneous transluminal angioplasty (PTA) is widely used for the treatment of PAD, restenosis remains a major drawback. Hydrogen sulfide (H2S) plays potential roles in many physiological processes, such as vasodilatation and inhibition of smooth muscle cell proliferation. However, little is known regarding its role in arterial restenosis. In this study, we induced atherosclerotic-like lesions in rabbits, and we treated the rabbits with balloon angioplasty (BA) in a similar manner as PTA performed in the clinic. The rabbits were treated with sodium hydrosulfide (NaHS, a donor of H2S) or DL-propargylglycine (PPG, an inhibitor of H2S synthase). Treatment with NaHS significantly inhibited arterial restenosis following BA by reducing the intimal area and the intima/media ratio, while PPG treatment had a tendency to result in more severe restenosis. NaHS treatment significantly reduced smooth muscle cell (SMC) proliferation and elevated SMC apoptosis in the neointima. In contrast, PPG induced a significant increase in SMC proliferation. In conclusion, H2S attenuates the progression of neointimal hyperplasia and inhibits restenosis after BA. This discovery may lead to potential novel therapies, which can improve the prognosis of PAD patients.

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Copy and paste a formatted citation
Spandidos Publications style
Ma B, Liang G, Zhang F, Chen Y and Zhang H: Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty. Mol Med Rep 5: 1497-1502, 2012.
APA
Ma, B., Liang, G., Zhang, F., Chen, Y., & Zhang, H. (2012). Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty. Molecular Medicine Reports, 5, 1497-1502. https://doi.org/10.3892/mmr.2012.853
MLA
Ma, B., Liang, G., Zhang, F., Chen, Y., Zhang, H."Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty". Molecular Medicine Reports 5.6 (2012): 1497-1502.
Chicago
Ma, B., Liang, G., Zhang, F., Chen, Y., Zhang, H."Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty". Molecular Medicine Reports 5, no. 6 (2012): 1497-1502. https://doi.org/10.3892/mmr.2012.853
Copy and paste a formatted citation
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Spandidos Publications style
Ma B, Liang G, Zhang F, Chen Y and Zhang H: Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty. Mol Med Rep 5: 1497-1502, 2012.
APA
Ma, B., Liang, G., Zhang, F., Chen, Y., & Zhang, H. (2012). Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty. Molecular Medicine Reports, 5, 1497-1502. https://doi.org/10.3892/mmr.2012.853
MLA
Ma, B., Liang, G., Zhang, F., Chen, Y., Zhang, H."Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty". Molecular Medicine Reports 5.6 (2012): 1497-1502.
Chicago
Ma, B., Liang, G., Zhang, F., Chen, Y., Zhang, H."Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty". Molecular Medicine Reports 5, no. 6 (2012): 1497-1502. https://doi.org/10.3892/mmr.2012.853
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