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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July 2012 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 6 Issue 1

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Article

Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms

  • Authors:
    • Mi-Young Jo
    • Young Gyu Kim
    • Yonghyun Kim
    • Se Jeong Lee
    • Mi Hyun Kim
    • Kyeung Min Joo
    • Hyeon Ho Kim
    • Do-Hyun Nam

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Samsung Medical Center and Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, Department of Neurosurgery, Chungbuk National University College of Medicine, Chungbuk, Republic of Korea, Department of Anatomy, Seoul National University College of Medicine, Seoul, Republic of Korea, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • Pages: 88-92
    |
    Published online on: April 11, 2012
       https://doi.org/10.3892/mmr.2012.868
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Abstract

Currently, clinically available options for treating glioblastoma (GBM) are quite limited, and there is a clear need to develop novel treatment strategies that can more effectively manage tumors. Here, we present a combination treatment of temozolomide (TMZ), a blood-brain barrier penetrating DNA alkylating agent, and ZD6474 (vandetanib), a VEGFR2 and EGFR dual-targeting anti-angiogenic agent, as a novel treatment strategy for GBM. In a U-87MG orthotopic xenograft model, the combination treatment provided a marked 94% tumor volume reduction. This reduction was greater than that achieved by monotherapy of either agent, and was correlated with a statistically significant reduction in microvessel density (CD31+ cells) and proliferation (PCNA+ cells). These results confirm the necessity to target angiogenesis in addition to utilizing cytotoxic approaches, and provide the rationale for application of TMZ + ZD6474 combination therapy for treating GBM patients in the clinical setting.

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Copy and paste a formatted citation
Spandidos Publications style
Jo M, Kim Y, Kim Y, Lee S, Kim M, Joo K, Kim H and Nam D: Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms. Mol Med Rep 6: 88-92, 2012.
APA
Jo, M., Kim, Y., Kim, Y., Lee, S., Kim, M., Joo, K. ... Nam, D. (2012). Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms. Molecular Medicine Reports, 6, 88-92. https://doi.org/10.3892/mmr.2012.868
MLA
Jo, M., Kim, Y., Kim, Y., Lee, S., Kim, M., Joo, K., Kim, H., Nam, D."Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms". Molecular Medicine Reports 6.1 (2012): 88-92.
Chicago
Jo, M., Kim, Y., Kim, Y., Lee, S., Kim, M., Joo, K., Kim, H., Nam, D."Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms". Molecular Medicine Reports 6, no. 1 (2012): 88-92. https://doi.org/10.3892/mmr.2012.868
Copy and paste a formatted citation
x
Spandidos Publications style
Jo M, Kim Y, Kim Y, Lee S, Kim M, Joo K, Kim H and Nam D: Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms. Mol Med Rep 6: 88-92, 2012.
APA
Jo, M., Kim, Y., Kim, Y., Lee, S., Kim, M., Joo, K. ... Nam, D. (2012). Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms. Molecular Medicine Reports, 6, 88-92. https://doi.org/10.3892/mmr.2012.868
MLA
Jo, M., Kim, Y., Kim, Y., Lee, S., Kim, M., Joo, K., Kim, H., Nam, D."Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms". Molecular Medicine Reports 6.1 (2012): 88-92.
Chicago
Jo, M., Kim, Y., Kim, Y., Lee, S., Kim, M., Joo, K., Kim, H., Nam, D."Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms". Molecular Medicine Reports 6, no. 1 (2012): 88-92. https://doi.org/10.3892/mmr.2012.868
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