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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells

  • Authors:
    • Yi Zhong
    • Jian Feng
    • Jiafu Li
    • Zhongcai Fan

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China
  • Pages: 4315-4319
    |
    Published online on: July 20, 2017
       https://doi.org/10.3892/mmr.2017.7037
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Abstract

The aim of the present study was to examine the effect of curcumin treatment on lipopolysaccharide (LPS)-induced matrix metalloproteinase‑2 (MMP‑2) activity, and assess whether the effects are mediated by the Ras/mitogen‑activated protein kinase kinase 1/2 (MEK1/2) signaling pathway in vascular smooth muscle cells (VSMCs). VSMCs were isolated from male Sprague‑Dawley rats. Protein expression levels were analyzed by western blotting. The activity of MMP‑2 was measured with gelatin zymography, and an electrophoretic mobility shift assay was used to detect the DNA binding activity of nuclear factor‑κB (NF‑κB). Curcumin treatment was demonstrated to inhibit LPS‑induced MMP‑2 activity in rat VSMCs. This inhibitory effect was partially blocked by ammonium pyrrolidinedithiocarbamate, an inhibitor of NF‑κB activation, and farnesylthiosalicylic acid, an inhibitor of Ras. In addition, the results of the present study indicated that LPS‑induced phosphorylation of Ras homolog family member A and MEK1/2 was significantly decreased by curcumin. Furthermore, NF‑κB p65 expression in the nucleus and the DNA binding activity of NF‑κB in rat LPS‑exposed VSMCs was decreased by curcumin. Taken together, these findings suggest that curcumin prevents of LPS‑induced MMP‑2 activity through Ras/MEK1/2 and NF‑κB signaling.

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Copy and paste a formatted citation
Spandidos Publications style
Zhong Y, Feng J, Li J and Fan Z: Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells. Mol Med Rep 16: 4315-4319, 2017.
APA
Zhong, Y., Feng, J., Li, J., & Fan, Z. (2017). Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells. Molecular Medicine Reports, 16, 4315-4319. https://doi.org/10.3892/mmr.2017.7037
MLA
Zhong, Y., Feng, J., Li, J., Fan, Z."Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells". Molecular Medicine Reports 16.4 (2017): 4315-4319.
Chicago
Zhong, Y., Feng, J., Li, J., Fan, Z."Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells". Molecular Medicine Reports 16, no. 4 (2017): 4315-4319. https://doi.org/10.3892/mmr.2017.7037
Copy and paste a formatted citation
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Spandidos Publications style
Zhong Y, Feng J, Li J and Fan Z: Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells. Mol Med Rep 16: 4315-4319, 2017.
APA
Zhong, Y., Feng, J., Li, J., & Fan, Z. (2017). Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells. Molecular Medicine Reports, 16, 4315-4319. https://doi.org/10.3892/mmr.2017.7037
MLA
Zhong, Y., Feng, J., Li, J., Fan, Z."Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells". Molecular Medicine Reports 16.4 (2017): 4315-4319.
Chicago
Zhong, Y., Feng, J., Li, J., Fan, Z."Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells". Molecular Medicine Reports 16, no. 4 (2017): 4315-4319. https://doi.org/10.3892/mmr.2017.7037
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