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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro

  • Authors:
    • Jie Zhang
    • Zeyu Wu
    • Ming Guan
    • Hongyan Lu
    • Xuming Mo

  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China, Department of Otolaryngology, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, P.R. China, Department of Pediatrics, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3869-3876
    |
    Published online on: July 21, 2017
       https://doi.org/10.3892/mmr.2017.7047
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Abstract

Apoptosis has important pathophysiological consequences contributing to pulmonary arterial hypertension (PAH). However, the mechanism underlying apoptosis in PAH remains unknown. Apoptosis repressor with caspase recruitment domain (ARC) is an essential factor in cell apoptosis, and regulates intrinsic and extrinsic apoptosis signaling pathways. It is hypothesized that ARC may be involved in the apoptotic responses of pulmonary arterial smooth muscle cells (PASMCs) following mild chronic injury. In the present study, serum deprivation (SD) was used to induce apoptosis of PASMCs. It was demonstrated that the expression of ARC in PASMCs was significantly increased following SD stimulation within 24 h, and ARC downregulation using small interfering RNA significantly enhanced the apoptosis of PASMCs following SD stimulation. In addition, the results demonstrated that ARC downregulation significantly increased the expression of proapoptotic factors and the level of reactive oxygen species (ROS), and decreased the mitochondrial membrane potential following SD exposure, suggesting ARC regulates the apoptosis of PASMCs via modulating mitochondrial function and ROS accumulation. The results of the present study revealed that ARC inhibition promotes the apoptosis of PASMCs following SD stimulation, and that ARC expression increases in the early stages of SD injury.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Wu Z, Guan M, Lu H and Mo X: Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro. Mol Med Rep 16: 3869-3876, 2017.
APA
Zhang, J., Wu, Z., Guan, M., Lu, H., & Mo, X. (2017). Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro. Molecular Medicine Reports, 16, 3869-3876. https://doi.org/10.3892/mmr.2017.7047
MLA
Zhang, J., Wu, Z., Guan, M., Lu, H., Mo, X."Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro". Molecular Medicine Reports 16.4 (2017): 3869-3876.
Chicago
Zhang, J., Wu, Z., Guan, M., Lu, H., Mo, X."Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro". Molecular Medicine Reports 16, no. 4 (2017): 3869-3876. https://doi.org/10.3892/mmr.2017.7047
Copy and paste a formatted citation
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Spandidos Publications style
Zhang J, Wu Z, Guan M, Lu H and Mo X: Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro. Mol Med Rep 16: 3869-3876, 2017.
APA
Zhang, J., Wu, Z., Guan, M., Lu, H., & Mo, X. (2017). Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro. Molecular Medicine Reports, 16, 3869-3876. https://doi.org/10.3892/mmr.2017.7047
MLA
Zhang, J., Wu, Z., Guan, M., Lu, H., Mo, X."Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro". Molecular Medicine Reports 16.4 (2017): 3869-3876.
Chicago
Zhang, J., Wu, Z., Guan, M., Lu, H., Mo, X."Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro". Molecular Medicine Reports 16, no. 4 (2017): 3869-3876. https://doi.org/10.3892/mmr.2017.7047
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