Open Access

lncRNA expression character associated with ischemic reperfusion injury

  • Authors:
    • Xiaowei Wu
    • Hongyi Zhu
    • Suhua Zhu
    • Maojuan Hao
    • Qingping Li
  • View Affiliations

  • Published online on: July 21, 2017     https://doi.org/10.3892/mmr.2017.7051
  • Pages: 3745-3752
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ischemic reperfusion injury (IRI) contributes to morbidity and mortality worldwide and results in a poor outcome for patients suffering from myocardial infarction. Ischemic post‑conditioning (IPostC), consisting of one or several brief periods of ischemia and reperfusion, generates powerful protection against IRI. The mechanism of IPostC initiation and development has previously been investigated, however still remains to be fully elucidated. Notably, long non‑coding (lnc) RNAs have previously been demonstrated to be important in cardiovascular diseases. However, there is little information about the systematic analysis of IRI‑associated lncRNA expression signature. The present study used microarrays to analyze the lncRNA expression characters of ischemic IPostc (corresponding to IRI), and demonstrated that 2,292 lncRNAs were observed to be upregulated and 1,848 lncRNAs downregulated. Gene ontology (GO) and Pathway analysis subsequently demonstrated that dysregulated lncRNAs participated in various biological processes, which are upregulated or downregulated in IPostC tissues. Finally, the present study verified that AK144818, ENS​MUS​T00000156637, ENS​MUS​T00000118342, ENS​MUS​T00000118149, uc008ane.1, ENS​MUS​T00000164933, ENS​MUS​T00000162347, ENS​MUS​T00000135945, and ENS​MUS​T00000176338, ENS​MUST00000120587, END​MUST00000155271, ENS​MUS​T00000125121 and Uc008thl.1 were associated with the initiation and development of IPostC. The present study may aid in the understanding of the initiation and development mechanisms of IPostC and provide novel and potential biomarkers that may be used in the diagnosis or as therapeutic targets in the treatment of IRI.

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October 2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
APA
Wu, X., Zhu, H., Zhu, S., Hao, M., & Li, Q. (2017). lncRNA expression character associated with ischemic reperfusion injury. Molecular Medicine Reports, 16, 3745-3752. https://doi.org/10.3892/mmr.2017.7051
MLA
Wu, X., Zhu, H., Zhu, S., Hao, M., Li, Q."lncRNA expression character associated with ischemic reperfusion injury". Molecular Medicine Reports 16.4 (2017): 3745-3752.
Chicago
Wu, X., Zhu, H., Zhu, S., Hao, M., Li, Q."lncRNA expression character associated with ischemic reperfusion injury". Molecular Medicine Reports 16, no. 4 (2017): 3745-3752. https://doi.org/10.3892/mmr.2017.7051