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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells

  • Authors:
    • Yunhong Li
    • Fan Li
    • Bin Bai
    • Zhenyong Wu
    • Xiaolin Hou
    • Ying Shen
    • Yin Wang

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Basic Medical College of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Department of Endocrinology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China
  • Pages: 4247-4252
    |
    Published online on: July 21, 2017
       https://doi.org/10.3892/mmr.2017.7056
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Abstract

It has been previously identified that α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPARs) are expressed in pancreatic β cells and regulate exocytosis and insulin release. It is known that protein interacting with C‑kinase 1 (PICK1) regulates trafficking and synaptic targeting of AMPARs in the central nervous system. However, it is unknown whether PICK1 regulates glutamate‑induced insulin release in β cells. The present study demonstrated that glutamate‑induced exocytosis was increased in β cells derived from PICK1‑knockout mice. In agreement with this result, adding PICK1 in β cells reduced glutamate‑induced exocytosis, whereas adding EVKI, a peptide that interrupts the interaction between AMPARs and PICK1, increased the exocytosis of β cells with the application of glutamate. Furthermore, the conductance of ATP‑sensitive potassium (KATP) channels was reduced in PICK1‑knockout mice, which was reversed by the overexpression of PICK1. In addition, PICK1 application reduced voltage oscillation induced by the closure of KATP. Taken together, the results indicate that PICK1 regulates glutamate‑induced exocytosis in β cells.

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Li F, Bai B, Wu Z, Hou X, Shen Y and Wang Y: Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells. Mol Med Rep 16: 4247-4252, 2017.
APA
Li, Y., Li, F., Bai, B., Wu, Z., Hou, X., Shen, Y., & Wang, Y. (2017). Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells. Molecular Medicine Reports, 16, 4247-4252. https://doi.org/10.3892/mmr.2017.7056
MLA
Li, Y., Li, F., Bai, B., Wu, Z., Hou, X., Shen, Y., Wang, Y."Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells". Molecular Medicine Reports 16.4 (2017): 4247-4252.
Chicago
Li, Y., Li, F., Bai, B., Wu, Z., Hou, X., Shen, Y., Wang, Y."Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells". Molecular Medicine Reports 16, no. 4 (2017): 4247-4252. https://doi.org/10.3892/mmr.2017.7056
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Li F, Bai B, Wu Z, Hou X, Shen Y and Wang Y: Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells. Mol Med Rep 16: 4247-4252, 2017.
APA
Li, Y., Li, F., Bai, B., Wu, Z., Hou, X., Shen, Y., & Wang, Y. (2017). Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells. Molecular Medicine Reports, 16, 4247-4252. https://doi.org/10.3892/mmr.2017.7056
MLA
Li, Y., Li, F., Bai, B., Wu, Z., Hou, X., Shen, Y., Wang, Y."Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells". Molecular Medicine Reports 16.4 (2017): 4247-4252.
Chicago
Li, Y., Li, F., Bai, B., Wu, Z., Hou, X., Shen, Y., Wang, Y."Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells". Molecular Medicine Reports 16, no. 4 (2017): 4247-4252. https://doi.org/10.3892/mmr.2017.7056
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