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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells

  • Authors:
    • Yang Xu
    • Zhixin Liang
    • Chunsun Li
    • Zhen Yang
    • Liangan Chen

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing 100853, P.R. China
  • Pages: 4159-4164
    |
    Published online on: July 27, 2017
       https://doi.org/10.3892/mmr.2017.7095
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Abstract

To win the war against lung cancer, the molecular mechanisms underlying its oncogenesis and metastasis must be identified in order to develop novel diagnosis and treatment strategies. We previously identified a novel gene, namely lung cancer metastasis related protein 1 (LCMR1; GenBank accession no. AY148462), which was demonstrated to be overexpressed in non‑small‑cell lung cancer. LCMR1 expression was significantly associated with clinical stage. To further understand the mechanism of LCMR1 in lung cancer, the present study screened a cDNA library from the lung cancer cell line 95D for proteins interacting with LCMR1 by yeast two‑hybrid assay, and the protein DEK was identified. Co‑immunoprecipitation and glutathione S‑transferase pull‑down assays were performed to confirm the interaction between LCMR1 and DEK in vivo and in vitro. The results demonstrated that the interaction was mediated primarily by the N‑terminal region of DEK, suggesting that LCMR1 may be involved in the regulation of cell apoptosis. Using RNA interference, DEK and LCMR1 were demonstrated to cooperate in the inhibition of apoptosis in lung cancer cells, and this effect was associated with the induced myeloid leukemia protein cell differentiation protein 1 pathway. The present findings suggest that LCMR1 might serve as a potential molecular target for lung cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Liang Z, Li C, Yang Z and Chen L: LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells. Mol Med Rep 16: 4159-4164, 2017.
APA
Xu, Y., Liang, Z., Li, C., Yang, Z., & Chen, L. (2017). LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells. Molecular Medicine Reports, 16, 4159-4164. https://doi.org/10.3892/mmr.2017.7095
MLA
Xu, Y., Liang, Z., Li, C., Yang, Z., Chen, L."LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells". Molecular Medicine Reports 16.4 (2017): 4159-4164.
Chicago
Xu, Y., Liang, Z., Li, C., Yang, Z., Chen, L."LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells". Molecular Medicine Reports 16, no. 4 (2017): 4159-4164. https://doi.org/10.3892/mmr.2017.7095
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Liang Z, Li C, Yang Z and Chen L: LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells. Mol Med Rep 16: 4159-4164, 2017.
APA
Xu, Y., Liang, Z., Li, C., Yang, Z., & Chen, L. (2017). LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells. Molecular Medicine Reports, 16, 4159-4164. https://doi.org/10.3892/mmr.2017.7095
MLA
Xu, Y., Liang, Z., Li, C., Yang, Z., Chen, L."LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells". Molecular Medicine Reports 16.4 (2017): 4159-4164.
Chicago
Xu, Y., Liang, Z., Li, C., Yang, Z., Chen, L."LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells". Molecular Medicine Reports 16, no. 4 (2017): 4159-4164. https://doi.org/10.3892/mmr.2017.7095
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