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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article Open Access

Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma

  • Authors:
    • Yanqing Yang
    • Zhenming Luo
    • Yiyang Qin
    • Yu Zhou
    • Longcai Gong
    • Jianfang Huang
    • Hong Wang

  • View Affiliations / Copyright

    Affiliations: Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Biomedicine Translational Institute, Jinan University, Guangzhou, Guangdong 510640, P.R. China, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94122, USA
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4015-4021
    |
    Published online on: July 27, 2017
       https://doi.org/10.3892/mmr.2017.7099
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Abstract

Basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor 1 (FGFR1) are associated with drug resistance in lung cancer. In the present study, mouse monoclonal antibodies (mAb) against human bFGF, targeting the binding site of bFGF with FGFR1 were produced, and the antitumor activity and inhibition of metastasis was studied in Lewis lung carcinoma (LLC). A total of four hybridoma cell strains that stably secreted bFGF mAb were obtained. mAbE12 was selected as the most effective for use in the following studies, with a relative affinity constant of 5.66x108 l/mol. mAbE12 was demonstrated to inhibit cell proliferation and tumor growth in vitro and in vivo. Furthermore, mAbE12 blocked migration and metastasis of LLC cells in vitro and in vivo. This occurred due to a mAbE12‑induced upregulation of E‑cadherin expression through the protein kinase B‑glycogen synthase kinase 3 β‑Snail pathway. These results suggested that mAbE12 may be a potential antibody for the treatment of lung cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Luo Z, Qin Y, Zhou Y, Gong L, Huang J and Wang H: Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma. Mol Med Rep 16: 4015-4021, 2017.
APA
Yang, Y., Luo, Z., Qin, Y., Zhou, Y., Gong, L., Huang, J., & Wang, H. (2017). Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma. Molecular Medicine Reports, 16, 4015-4021. https://doi.org/10.3892/mmr.2017.7099
MLA
Yang, Y., Luo, Z., Qin, Y., Zhou, Y., Gong, L., Huang, J., Wang, H."Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma". Molecular Medicine Reports 16.4 (2017): 4015-4021.
Chicago
Yang, Y., Luo, Z., Qin, Y., Zhou, Y., Gong, L., Huang, J., Wang, H."Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma". Molecular Medicine Reports 16, no. 4 (2017): 4015-4021. https://doi.org/10.3892/mmr.2017.7099
Copy and paste a formatted citation
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Spandidos Publications style
Yang Y, Luo Z, Qin Y, Zhou Y, Gong L, Huang J and Wang H: Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma. Mol Med Rep 16: 4015-4021, 2017.
APA
Yang, Y., Luo, Z., Qin, Y., Zhou, Y., Gong, L., Huang, J., & Wang, H. (2017). Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma. Molecular Medicine Reports, 16, 4015-4021. https://doi.org/10.3892/mmr.2017.7099
MLA
Yang, Y., Luo, Z., Qin, Y., Zhou, Y., Gong, L., Huang, J., Wang, H."Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma". Molecular Medicine Reports 16.4 (2017): 4015-4021.
Chicago
Yang, Y., Luo, Z., Qin, Y., Zhou, Y., Gong, L., Huang, J., Wang, H."Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma". Molecular Medicine Reports 16, no. 4 (2017): 4015-4021. https://doi.org/10.3892/mmr.2017.7099
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