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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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Article Open Access

MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles

  • Authors:
    • Yanhui Zhang
    • Hongyan Zhang
    • Lijun Ding
    • Hailu Zhang
    • Pengli Zhang
    • Haizhen Jiang
    • Bo Tan
    • Zongwu Deng

  • View Affiliations / Copyright

    Affiliations: College of Sciences, Shanghai University, Shanghai 200444, P.R. China, CAS Key Laboratory of Nano‑Bio Interface and Division of Nanobionics Research, Suzhou Institute of Nano‑Tech and Nano‑Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, P.R. China, Center for Reproductive Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4068-4074
    |
    Published online on: July 27, 2017
       https://doi.org/10.3892/mmr.2017.7100
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Abstract

A small molecule tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd‑DOTA)4‑TPP agent is used to label human mesenchymal stem cells (hMSCs) via electroporation (EP). The present study assessed the cytotoxicity of cell labeling, in addition to its effect on cell differentiation potential. There were no significant adverse effects on cell viability or differentiation induced by either EP or cellular uptake of (Gd‑DOTA)4‑TPP. Labeled live and dead hMSCs were transplanted into mouse forelimb muscles. T2‑weighted magnetic resonance imaging (MRI) was used to track the in vivo fate of the cell transplants. The labeling and imaging strategy allowed long term tracking of the cell transplants and unambiguous distinguishing of the cell transplants from their surrounding tissues. Cell migration was observed for live hMSCs injected into subcutaneous tissues, however not for either live or dead hMSCS injected into limb muscles. A slow clearance process occurred of the dead cell transplants in the limb muscular tissue. The MRI results therefore reveal that the fate and physiological activities of cell transplants depend on the nature of their host tissue.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Zhang H, Ding L, Zhang H, Zhang P, Jiang H, Tan B and Deng Z: MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles. Mol Med Rep 16: 4068-4074, 2017.
APA
Zhang, Y., Zhang, H., Ding, L., Zhang, H., Zhang, P., Jiang, H. ... Deng, Z. (2017). MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles. Molecular Medicine Reports, 16, 4068-4074. https://doi.org/10.3892/mmr.2017.7100
MLA
Zhang, Y., Zhang, H., Ding, L., Zhang, H., Zhang, P., Jiang, H., Tan, B., Deng, Z."MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles". Molecular Medicine Reports 16.4 (2017): 4068-4074.
Chicago
Zhang, Y., Zhang, H., Ding, L., Zhang, H., Zhang, P., Jiang, H., Tan, B., Deng, Z."MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles". Molecular Medicine Reports 16, no. 4 (2017): 4068-4074. https://doi.org/10.3892/mmr.2017.7100
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Zhang H, Ding L, Zhang H, Zhang P, Jiang H, Tan B and Deng Z: MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles. Mol Med Rep 16: 4068-4074, 2017.
APA
Zhang, Y., Zhang, H., Ding, L., Zhang, H., Zhang, P., Jiang, H. ... Deng, Z. (2017). MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles. Molecular Medicine Reports, 16, 4068-4074. https://doi.org/10.3892/mmr.2017.7100
MLA
Zhang, Y., Zhang, H., Ding, L., Zhang, H., Zhang, P., Jiang, H., Tan, B., Deng, Z."MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles". Molecular Medicine Reports 16.4 (2017): 4068-4074.
Chicago
Zhang, Y., Zhang, H., Ding, L., Zhang, H., Zhang, P., Jiang, H., Tan, B., Deng, Z."MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles". Molecular Medicine Reports 16, no. 4 (2017): 4068-4074. https://doi.org/10.3892/mmr.2017.7100
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