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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Article Open Access

Characterization and predicted role of microRNA expression profiles associated with early childhood obesity

  • Authors:
    • Shengrong Ouyang
    • Renqiao Tang
    • Zhuo Liu
    • Feifei Ma
    • Yuanyuan Li
    • Jianxin Wu

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, P.R. China, Graduate School of Peking Union Medical College, Beijing 100730, P.R. China
    Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3799-3806
    |
    Published online on: July 31, 2017
       https://doi.org/10.3892/mmr.2017.7118
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Abstract

MicroRNAs (miRNAs) are implicated in the pathogenesis of obesity. The aim of the present study was to characterize the miRNA profile associated with early childhood obesity in peripheral blood mononuclear cells (PBMCs). A total of 12 children (6 obese and 6 lean controls) aged 36 months old to 48 months old were recruited. The miRNA expression profile from PBMCs was detected using the multiplexed NanoString nCounter system. Bioinformatics was employed to detect target genes and miRNA‑regulated biological function. A total of 9 differentially expressed miRNAs were identified in obese children compared with lean children (P<0.05). Among the 9 miRNAs, miR‑199a‑3p/miR‑199b‑3p and miR‑4454 presented at least a 1.5‑fold change in expression. A total of 643 potential target genes were regulated by the three miRNAs, and 291 of the potential genes were involved in a protein interaction network. Gene ontology annotation indicated that 291 potential genes were enriched in 14 biological process annotations and 2 molecular function annotations. miRNA dysregulation may be involved in early childhood obesity.

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Copy and paste a formatted citation
Spandidos Publications style
Ouyang S, Tang R, Liu Z, Ma F, Li Y and Wu J: Characterization and predicted role of microRNA expression profiles associated with early childhood obesity. Mol Med Rep 16: 3799-3806, 2017.
APA
Ouyang, S., Tang, R., Liu, Z., Ma, F., Li, Y., & Wu, J. (2017). Characterization and predicted role of microRNA expression profiles associated with early childhood obesity. Molecular Medicine Reports, 16, 3799-3806. https://doi.org/10.3892/mmr.2017.7118
MLA
Ouyang, S., Tang, R., Liu, Z., Ma, F., Li, Y., Wu, J."Characterization and predicted role of microRNA expression profiles associated with early childhood obesity". Molecular Medicine Reports 16.4 (2017): 3799-3806.
Chicago
Ouyang, S., Tang, R., Liu, Z., Ma, F., Li, Y., Wu, J."Characterization and predicted role of microRNA expression profiles associated with early childhood obesity". Molecular Medicine Reports 16, no. 4 (2017): 3799-3806. https://doi.org/10.3892/mmr.2017.7118
Copy and paste a formatted citation
x
Spandidos Publications style
Ouyang S, Tang R, Liu Z, Ma F, Li Y and Wu J: Characterization and predicted role of microRNA expression profiles associated with early childhood obesity. Mol Med Rep 16: 3799-3806, 2017.
APA
Ouyang, S., Tang, R., Liu, Z., Ma, F., Li, Y., & Wu, J. (2017). Characterization and predicted role of microRNA expression profiles associated with early childhood obesity. Molecular Medicine Reports, 16, 3799-3806. https://doi.org/10.3892/mmr.2017.7118
MLA
Ouyang, S., Tang, R., Liu, Z., Ma, F., Li, Y., Wu, J."Characterization and predicted role of microRNA expression profiles associated with early childhood obesity". Molecular Medicine Reports 16.4 (2017): 3799-3806.
Chicago
Ouyang, S., Tang, R., Liu, Z., Ma, F., Li, Y., Wu, J."Characterization and predicted role of microRNA expression profiles associated with early childhood obesity". Molecular Medicine Reports 16, no. 4 (2017): 3799-3806. https://doi.org/10.3892/mmr.2017.7118
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