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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma

  • Authors:
    • Lu Jin
    • Huifang Fu
    • Jing Quan
    • Xiang Pan
    • Tao He
    • Jia Hu
    • Yifan Li
    • Hang Li
    • Yu Yang
    • Jing Ye
    • Fangting Zhang
    • Liangchao Ni
    • Shangqi Yang
    • Yongqing Lai
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Shenzhen, Guangdong 518036, P.R. China
  • Pages: 4463-4468
    |
    Published online on: August 2, 2017
       https://doi.org/10.3892/mmr.2017.7135
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Abstract

Renal cell carcinoma (RCC) is the third most common cancer in the urological system; however, the pathogenesis remains unknown. Accumulating evidence has demonstrated that long non‑coding RNAs are dysregulated in various tumors and serves an important role in tumorigenesis and development. In the present study, expression of lncRNA differentiation antagonizing non‑protein coding RNA (DANCR) in 24 paired RCC and adjacent normal tissues was detected by reverse transcription‑quantitative polymerase chain reaction. The results revealed that DANCR is downregulated in RCC tissues compared with adjacent normal tissues. Subsequent study revealed that overexpression of lncRNA DANCR by transfection of pcDNA3.1‑DANCR could suppress 786‑O and ACHN (RCC cell) proliferation, migration and invasion, and induce apoptosis compared with cells transfected with the pcDNA3.1 vector. The results revealed that DANCR functions as a tumor suppressor in RCC. In conclusion, the present study, to the best of our knowledge, was the first to reveal DANCR as a tumor suppressor. The results implicate DANCR as a potential biomarker of RCC, and further study will be focused on the clinical significance and signaling pathways of DANCR.

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Copy and paste a formatted citation
Spandidos Publications style
Jin L, Fu H, Quan J, Pan X, He T, Hu J, Li Y, Li H, Yang Y, Ye J, Ye J, et al: Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma. Mol Med Rep 16: 4463-4468, 2017.
APA
Jin, L., Fu, H., Quan, J., Pan, X., He, T., Hu, J. ... Lai, Y. (2017). Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma. Molecular Medicine Reports, 16, 4463-4468. https://doi.org/10.3892/mmr.2017.7135
MLA
Jin, L., Fu, H., Quan, J., Pan, X., He, T., Hu, J., Li, Y., Li, H., Yang, Y., Ye, J., Zhang, F., Ni, L., Yang, S., Lai, Y."Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma". Molecular Medicine Reports 16.4 (2017): 4463-4468.
Chicago
Jin, L., Fu, H., Quan, J., Pan, X., He, T., Hu, J., Li, Y., Li, H., Yang, Y., Ye, J., Zhang, F., Ni, L., Yang, S., Lai, Y."Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma". Molecular Medicine Reports 16, no. 4 (2017): 4463-4468. https://doi.org/10.3892/mmr.2017.7135
Copy and paste a formatted citation
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Spandidos Publications style
Jin L, Fu H, Quan J, Pan X, He T, Hu J, Li Y, Li H, Yang Y, Ye J, Ye J, et al: Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma. Mol Med Rep 16: 4463-4468, 2017.
APA
Jin, L., Fu, H., Quan, J., Pan, X., He, T., Hu, J. ... Lai, Y. (2017). Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma. Molecular Medicine Reports, 16, 4463-4468. https://doi.org/10.3892/mmr.2017.7135
MLA
Jin, L., Fu, H., Quan, J., Pan, X., He, T., Hu, J., Li, Y., Li, H., Yang, Y., Ye, J., Zhang, F., Ni, L., Yang, S., Lai, Y."Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma". Molecular Medicine Reports 16.4 (2017): 4463-4468.
Chicago
Jin, L., Fu, H., Quan, J., Pan, X., He, T., Hu, J., Li, Y., Li, H., Yang, Y., Ye, J., Zhang, F., Ni, L., Yang, S., Lai, Y."Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma". Molecular Medicine Reports 16, no. 4 (2017): 4463-4468. https://doi.org/10.3892/mmr.2017.7135
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