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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Article Open Access

Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1

  • Authors:
    • Hao Jiang
    • Si‑Mei Shen
    • Jie Yin
    • Peng‑Peng Zhang
    • Yi Shi

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210002, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4553-4560
    |
    Published online on: August 2, 2017
       https://doi.org/10.3892/mmr.2017.7138
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Abstract

Influenza A affects a large population worldwide. Influenza virus evades immune responses via various mechanisms, including through the modification of the immune microenvironment. Influenza virus non‑structural protein 1 (NS1) encoded by the virus genome inhibits type I interferon (IFN) signaling pathways, which is essential for viral clearance. However, the precise mechanisms of NS1‑mediated immune suppression remain poorly understood. The results of the present study demonstrated that mice infected with NS1‑expressing influenza A H1N1 virus had lower expression levels of IFNβ in the lung. In addition, it was revealed that the human alveolar epithelial A549 cell line infected with influenza virus A H1N1 produced antiviral IFNβ. The production of IFNβ during infection was demonstrated to be a self‑dependent autocrine process. A549 cells transfected with H1N1 NS1 lost the ability to produce IFNβ upon H1N1 infection or IFNβ stimulation. NS1 inhibited the expression of IFN receptors. Furthermore, NS1 inhibited the activation of signal transducers and activators of transcription (STAT)1 and STAT2, as well as the consequent IFNβ production. These data indicate that NS1 serves an important role during virus evasion by affecting the production of IFNβ via multiple mechanisms.

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Copy and paste a formatted citation
Spandidos Publications style
Jiang H, Shen SM, Yin J, Zhang PP and Shi Y: Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1. Mol Med Rep 16: 4553-4560, 2017.
APA
Jiang, H., Shen, S., Yin, J., Zhang, P., & Shi, Y. (2017). Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1. Molecular Medicine Reports, 16, 4553-4560. https://doi.org/10.3892/mmr.2017.7138
MLA
Jiang, H., Shen, S., Yin, J., Zhang, P., Shi, Y."Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1". Molecular Medicine Reports 16.4 (2017): 4553-4560.
Chicago
Jiang, H., Shen, S., Yin, J., Zhang, P., Shi, Y."Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1". Molecular Medicine Reports 16, no. 4 (2017): 4553-4560. https://doi.org/10.3892/mmr.2017.7138
Copy and paste a formatted citation
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Spandidos Publications style
Jiang H, Shen SM, Yin J, Zhang PP and Shi Y: Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1. Mol Med Rep 16: 4553-4560, 2017.
APA
Jiang, H., Shen, S., Yin, J., Zhang, P., & Shi, Y. (2017). Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1. Molecular Medicine Reports, 16, 4553-4560. https://doi.org/10.3892/mmr.2017.7138
MLA
Jiang, H., Shen, S., Yin, J., Zhang, P., Shi, Y."Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1". Molecular Medicine Reports 16.4 (2017): 4553-4560.
Chicago
Jiang, H., Shen, S., Yin, J., Zhang, P., Shi, Y."Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1". Molecular Medicine Reports 16, no. 4 (2017): 4553-4560. https://doi.org/10.3892/mmr.2017.7138
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