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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model

  • Authors:
    • Jia Song
    • Xue Wang
    • Yu Huang
    • Yidi Qu
    • Lesheng Teng
    • Di Wang
    • Zhaoli Meng

  • View Affiliations / Copyright

    Affiliations: School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China, Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin 130061, P.R. China
  • Pages: 5043-5049
    |
    Published online on: August 2, 2017
       https://doi.org/10.3892/mmr.2017.7145
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Abstract

Marasmius androsaceus (M. androsaceus), a medicinal fungus, has various pharmacological activities including antidepression. The present study investigated the effects of exopolysaccharides obtained during M. androsaceus submerged fermentation in a chronic unpredictable mild stress (CUMS)‑induced depression rat model. Similar to fluoxetine (positive drug), 4‑week administration of M. androsaceus exopolysaccharides (MEPS) at doses of 6, 30 and 150 mg/kg strongly enhanced bodyweight gain and sucrose consumption, and reduced the immobility time in forced swimming test and tail suspension test in CUMS rats. MEPS resulted in significant enhancement on the levels of noradrenalin, dopamine, 5‑hydroxytryptamine (5‑HT), and 5‑hydroxyindoleacetic acid in the serum and hypothalamus of CUMS rats, as detected by ELISA. Western blotting results revealed that MEPS upregulated the protein expression levels of tyrosine hydroxylase in the hypothalamus of CUMS rats. In conclusion, these results confirmed the antidepressant‑like effects of MEPS, and suggested that the monoamine neurotransmitter system is involved in its antidepressive effects in a CUMS rat model. The present study provided evidence for the clinical application of MEPS as an effective agent against depression.

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Copy and paste a formatted citation
Spandidos Publications style
Song J, Wang X, Huang Y, Qu Y, Teng L, Wang D and Meng Z: Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model. Mol Med Rep 16: 5043-5049, 2017.
APA
Song, J., Wang, X., Huang, Y., Qu, Y., Teng, L., Wang, D., & Meng, Z. (2017). Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model. Molecular Medicine Reports, 16, 5043-5049. https://doi.org/10.3892/mmr.2017.7145
MLA
Song, J., Wang, X., Huang, Y., Qu, Y., Teng, L., Wang, D., Meng, Z."Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model". Molecular Medicine Reports 16.4 (2017): 5043-5049.
Chicago
Song, J., Wang, X., Huang, Y., Qu, Y., Teng, L., Wang, D., Meng, Z."Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model". Molecular Medicine Reports 16, no. 4 (2017): 5043-5049. https://doi.org/10.3892/mmr.2017.7145
Copy and paste a formatted citation
x
Spandidos Publications style
Song J, Wang X, Huang Y, Qu Y, Teng L, Wang D and Meng Z: Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model. Mol Med Rep 16: 5043-5049, 2017.
APA
Song, J., Wang, X., Huang, Y., Qu, Y., Teng, L., Wang, D., & Meng, Z. (2017). Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model. Molecular Medicine Reports, 16, 5043-5049. https://doi.org/10.3892/mmr.2017.7145
MLA
Song, J., Wang, X., Huang, Y., Qu, Y., Teng, L., Wang, D., Meng, Z."Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model". Molecular Medicine Reports 16.4 (2017): 5043-5049.
Chicago
Song, J., Wang, X., Huang, Y., Qu, Y., Teng, L., Wang, D., Meng, Z."Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model". Molecular Medicine Reports 16, no. 4 (2017): 5043-5049. https://doi.org/10.3892/mmr.2017.7145
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