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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Article Open Access

Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma

  • Authors:
    • Hao Wu
    • Jianqiu Chen
    • Qiang Wang
    • Yong Yin
    • Peng Da
    • Huijun Le
    • Zhenxin Zhang
    • Xiaoxia Qiu

  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology/Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Otolaryngology Head and Neck Surgery, General Hospital of Jinan Military Region, Jinan, Shandong 250031, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4664-4670
    |
    Published online on: August 3, 2017
       https://doi.org/10.3892/mmr.2017.7155
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Abstract

HCLS1‑associated protein X‑1 (HAX‑1) is highly expressed or overexpressed in various types of human tumor, and its overexpression is associated with cancer metastasis and cellular proliferation. However, the precise molecular mechanism involved in HAX‑1‑associated proliferation and metastasis in hypopharyngeal carcinoma is unknown. The present study aimed to investigate the role of HAX‑1 in the metastasis and proliferation of hypopharyngeal carcinoma. Reverse transcription‑quantitative polymerase chain reaction analysis and western blotting indicated that HAX‑1 was overexpressed in hypopharyngeal carcinoma specimens. MTT, clone formation and transwell assays were performed to detect the effects of HAX‑1 knockdown or overexpression on the major oncogenic properties of the FaDu hypopharyngeal carcinoma cell line. Downregulation of HAX‑1 was observed to significantly suppress cellular proliferation, migration and clonal. By contrast, overexpression of HAX‑1 significantly promoted cellular proliferation, migration and clonal formation. Furthermore, HAX‑1 knockdown markedly suppressed epithelial‑mesenchymal transition. In conclusion, HAX‑1 is a potential oncogene, and may promote the tumorigenesis and progression of hypopharyngeal carcinoma, as well as serve as a valuable molecular target for the treatment of hypopharyngeal carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Wu H, Chen J, Wang Q, Yin Y, Da P, Le H, Zhang Z and Qiu X: Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma. Mol Med Rep 16: 4664-4670, 2017.
APA
Wu, H., Chen, J., Wang, Q., Yin, Y., Da, P., Le, H. ... Qiu, X. (2017). Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma. Molecular Medicine Reports, 16, 4664-4670. https://doi.org/10.3892/mmr.2017.7155
MLA
Wu, H., Chen, J., Wang, Q., Yin, Y., Da, P., Le, H., Zhang, Z., Qiu, X."Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma". Molecular Medicine Reports 16.4 (2017): 4664-4670.
Chicago
Wu, H., Chen, J., Wang, Q., Yin, Y., Da, P., Le, H., Zhang, Z., Qiu, X."Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma". Molecular Medicine Reports 16, no. 4 (2017): 4664-4670. https://doi.org/10.3892/mmr.2017.7155
Copy and paste a formatted citation
x
Spandidos Publications style
Wu H, Chen J, Wang Q, Yin Y, Da P, Le H, Zhang Z and Qiu X: Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma. Mol Med Rep 16: 4664-4670, 2017.
APA
Wu, H., Chen, J., Wang, Q., Yin, Y., Da, P., Le, H. ... Qiu, X. (2017). Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma. Molecular Medicine Reports, 16, 4664-4670. https://doi.org/10.3892/mmr.2017.7155
MLA
Wu, H., Chen, J., Wang, Q., Yin, Y., Da, P., Le, H., Zhang, Z., Qiu, X."Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma". Molecular Medicine Reports 16.4 (2017): 4664-4670.
Chicago
Wu, H., Chen, J., Wang, Q., Yin, Y., Da, P., Le, H., Zhang, Z., Qiu, X."Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma". Molecular Medicine Reports 16, no. 4 (2017): 4664-4670. https://doi.org/10.3892/mmr.2017.7155
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