Open Access

Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation

  • Authors:
    • Xiang Li
    • Qin Fang
    • Xiaohong Tian
    • Xiaohong Wang
    • Qiang Ao
    • Weijian Hou
    • Hao Tong
    • Jun Fan
    • Shuling Bai
  • View Affiliations

  • Published online on: August 4, 2017     https://doi.org/10.3892/mmr.2017.7169
  • Pages: 4455-4462
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Angiogenesis is an important process in the pathogenesis of aortic aneurysm. The aim of the present study was to investigate the angiogenic balance and the expression of vascular endothelial growth factor (VEGF) in thoracic aortic aneurysm (TAA). A previous study demonstrated that curcumin exerts a marked effect on aortic aneurysm development. Therefore, the present study determined whether curcumin is able to modulate angiogenesis and inflammatory signaling in TAA by collecting human TAA samples and establishing a rat TAA model using periaortic application of CaCl2. TAA rats were treated with curcumin or 1% carboxymethyl cellulose and were sacrificed 4 weeks after the operation. All tissue specimens were analyzed by histological staining, immunohistochemistry and western blotting. Human TAA samples exhibited increased neovascularization and VEGF expression when compared with normal aortic walls. In rat tissues, treatment with curcumin resulted in reduced aneurysm size and restored the wavy structure of the elastic lamellae. In addition, curcumin decreased neovascularization and the expression of VEGF. Immunohistochemical analysis indicated that curcumin significantly inhibited infiltration of cluster of differentiation (CD)3+ and CD68+ cells in TAA. Furthermore, curcumin treatment decreased the expression of vascular cell adhesion molecule‑1, intracellular adhesion molecule‑1, monocyte chemoattractant protein‑1 and tumor necrosis factor‑α. Collectively, the results demonstrated that angiogenesis and VEGF expression were increased in the aortic wall in TAA. Treatment with curcumin inhibited TAA development in rats, which was associated with suppression of VEGF expression. In addition, curcumin attenuated inflammatory cell infiltration and suppressed inflammatory factor expression in the periaortic tissue of TAA.

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October 2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
APA
Li, X., Fang, Q., Tian, X., Wang, X., Ao, Q., Hou, W. ... Bai, S. (2017). Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation. Molecular Medicine Reports, 16, 4455-4462. https://doi.org/10.3892/mmr.2017.7169
MLA
Li, X., Fang, Q., Tian, X., Wang, X., Ao, Q., Hou, W., Tong, H., Fan, J., Bai, S."Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation". Molecular Medicine Reports 16.4 (2017): 4455-4462.
Chicago
Li, X., Fang, Q., Tian, X., Wang, X., Ao, Q., Hou, W., Tong, H., Fan, J., Bai, S."Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation". Molecular Medicine Reports 16, no. 4 (2017): 4455-4462. https://doi.org/10.3892/mmr.2017.7169