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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway

  • Authors:
    • Yikun Qu
    • Chunfang Hao
    • Jian Xu
    • Zhuoxin Cheng
    • Weiqun Wang
    • Hong Liu

  • View Affiliations / Copyright

    Affiliations: The Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of General Surgery, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China, Department of Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China
  • Pages: 5036-5042
    |
    Published online on: August 7, 2017
       https://doi.org/10.3892/mmr.2017.7180
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Abstract

Breast cancer is a very common malignant tumor, whose incidence ranks the first among various types of cancer in women worldwide. An important hallmark of cancer is the activation of oncogenes, which lead to overgrowth of cancer cells. Therefore, it is necessary to identify the critical genes involved in regulating the progression of breast cancer and elucidate the corresponding molecular mechanisms. The present study demonstrated that integrin‑linked kinase (ILK) overexpression promoted cell proliferation and growth in MCF‑7 cells, while ILK knockdown led to growth arrest in MDA‑MB‑231 cells. In addition, activation of the phosphoinositide 3‑kinase (PI3K)/Akt pathway was positively regulated by ILK, suggesting that the regulatory effects of ILK on cell growth and proliferation may be at least in part mediated by PI3K/Akt signaling. These results indicated that ILK promoted cell proliferation and growth in breast cancer cells through activation of the PI3K/Akt pathway, suggesting that ILK may be considered to be a potential therapeutic target for the therapy of breast cancer in the future.

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Copy and paste a formatted citation
Spandidos Publications style
Qu Y, Hao C, Xu J, Cheng Z, Wang W and Liu H: ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway. Mol Med Rep 16: 5036-5042, 2017.
APA
Qu, Y., Hao, C., Xu, J., Cheng, Z., Wang, W., & Liu, H. (2017). ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway. Molecular Medicine Reports, 16, 5036-5042. https://doi.org/10.3892/mmr.2017.7180
MLA
Qu, Y., Hao, C., Xu, J., Cheng, Z., Wang, W., Liu, H."ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway". Molecular Medicine Reports 16.4 (2017): 5036-5042.
Chicago
Qu, Y., Hao, C., Xu, J., Cheng, Z., Wang, W., Liu, H."ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway". Molecular Medicine Reports 16, no. 4 (2017): 5036-5042. https://doi.org/10.3892/mmr.2017.7180
Copy and paste a formatted citation
x
Spandidos Publications style
Qu Y, Hao C, Xu J, Cheng Z, Wang W and Liu H: ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway. Mol Med Rep 16: 5036-5042, 2017.
APA
Qu, Y., Hao, C., Xu, J., Cheng, Z., Wang, W., & Liu, H. (2017). ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway. Molecular Medicine Reports, 16, 5036-5042. https://doi.org/10.3892/mmr.2017.7180
MLA
Qu, Y., Hao, C., Xu, J., Cheng, Z., Wang, W., Liu, H."ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway". Molecular Medicine Reports 16.4 (2017): 5036-5042.
Chicago
Qu, Y., Hao, C., Xu, J., Cheng, Z., Wang, W., Liu, H."ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway". Molecular Medicine Reports 16, no. 4 (2017): 5036-5042. https://doi.org/10.3892/mmr.2017.7180
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