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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article Open Access

Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues

  • Authors:
    • Qian Tan
    • Yalan Yu
    • Nandi Li
    • Wei Jing
    • Hu Zhou
    • Shili Qiu
    • Chunzi Liang
    • Mingxia Yu
    • Jiancheng Tu
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Clinical Laboratory of Medicine and Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4721-4729
    |
    Published online on: August 9, 2017
       https://doi.org/10.3892/mmr.2017.7196
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Abstract

Non-small cell lung cancer (NSCLC) is a fatal disease to human health. Despite the advanced progresses in cancer therapy during the past decades, NSCLC still remains the leading cause of cancer death worldwide. The long non‑coding RNAs (lncRNAs) recently have been considered as key regulators of tumor malignant. Previous studies identified that long non‑coding RNAs, linc00312 and linc00673 are markedly associated with lung cancer. However, current understanding of the two lncRNAs involving in NSCLC remains unclear. The aim of the present study was to profile their expression and clinicopathological significance in 76 patients' NSCLC tissues compared to non‑tumor tissues using reverse transcription-quantitative polymerase chain reaction. Data have indicated that the linc00312 expression level was significantly decreased in NSCLC tissues (P<0.001), while a higher linc00673 level has been detected in the same tumor tissues (P<0.01). In addition, the low expression of linc00312 was associated with the Tumor‑Node‑Metastasis stage of NSCLC (P<0.05), whereas the high expression of linc00673 was related with the histological types of NSCLC (P<0.05). In conclusion, lncRNA 00312 and 00673 may serve as potential novel biomarkers for lung cancer early diagnosis, which may play a vital role in treatments of NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Tan Q, Yu Y, Li N, Jing W, Zhou H, Qiu S, Liang C, Yu M and Tu J: Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues. Mol Med Rep 16: 4721-4729, 2017.
APA
Tan, Q., Yu, Y., Li, N., Jing, W., Zhou, H., Qiu, S. ... Tu, J. (2017). Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues. Molecular Medicine Reports, 16, 4721-4729. https://doi.org/10.3892/mmr.2017.7196
MLA
Tan, Q., Yu, Y., Li, N., Jing, W., Zhou, H., Qiu, S., Liang, C., Yu, M., Tu, J."Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues". Molecular Medicine Reports 16.4 (2017): 4721-4729.
Chicago
Tan, Q., Yu, Y., Li, N., Jing, W., Zhou, H., Qiu, S., Liang, C., Yu, M., Tu, J."Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues". Molecular Medicine Reports 16, no. 4 (2017): 4721-4729. https://doi.org/10.3892/mmr.2017.7196
Copy and paste a formatted citation
x
Spandidos Publications style
Tan Q, Yu Y, Li N, Jing W, Zhou H, Qiu S, Liang C, Yu M and Tu J: Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues. Mol Med Rep 16: 4721-4729, 2017.
APA
Tan, Q., Yu, Y., Li, N., Jing, W., Zhou, H., Qiu, S. ... Tu, J. (2017). Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues. Molecular Medicine Reports, 16, 4721-4729. https://doi.org/10.3892/mmr.2017.7196
MLA
Tan, Q., Yu, Y., Li, N., Jing, W., Zhou, H., Qiu, S., Liang, C., Yu, M., Tu, J."Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues". Molecular Medicine Reports 16.4 (2017): 4721-4729.
Chicago
Tan, Q., Yu, Y., Li, N., Jing, W., Zhou, H., Qiu, S., Liang, C., Yu, M., Tu, J."Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues". Molecular Medicine Reports 16, no. 4 (2017): 4721-4729. https://doi.org/10.3892/mmr.2017.7196
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