Open Access

Angelicin inhibits liver cancer growth in vitro and in vivo

  • Authors:
    • Fengliang Wang
    • Jun Li
    • Rong Li
    • Guohua Pan
    • Mingxia Bai
    • Qiang Huang
  • View Affiliations

  • Published online on: August 10, 2017     https://doi.org/10.3892/mmr.2017.7219
  • Pages: 5441-5449
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have reported that angelicin exerted antiproliferative effects on several types of tumor cell. However, to the best of our knowledge, the effects of angelicin monotherapy on human liver cancer remain to be investigated. In the present study, the antitumor activity of angelicin was evaluated in vitro and in vivo, and the molecular mechanisms underlying its effects were investigated. The present results revealed that angelicin induced apoptosis in liver cancer cells in a dose‑ and time‑dependent manner. Furthermore, in HepG2 and Huh‑7 cells, angelicin‑induced apoptosis was demonstrated to be mitochondria dependent, involving the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/RAC‑α serine/threonine-protein kinase signaling pathway. In addition, administration of angelicin to mice bearing liver tumor xenografts inhibited tumor growth, without producing significant secondary adverse effects. These results suggested that angelicin may have potential as a novel therapeutic agent for the treatment of patients with liver cancer.

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October 2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Wang, F., Li, J., Li, R., Pan, G., Bai, M., & Huang, Q. (2017). Angelicin inhibits liver cancer growth in vitro and in vivo. Molecular Medicine Reports, 16, 5441-5449. https://doi.org/10.3892/mmr.2017.7219
MLA
Wang, F., Li, J., Li, R., Pan, G., Bai, M., Huang, Q."Angelicin inhibits liver cancer growth in vitro and in vivo". Molecular Medicine Reports 16.4 (2017): 5441-5449.
Chicago
Wang, F., Li, J., Li, R., Pan, G., Bai, M., Huang, Q."Angelicin inhibits liver cancer growth in vitro and in vivo". Molecular Medicine Reports 16, no. 4 (2017): 5441-5449. https://doi.org/10.3892/mmr.2017.7219